Inflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer
Immunology: Weight tied to inflammation in fat surrounding tumor Overweight and obese women with breast cancer show more inflammation in their mammary fat tissue, creating an environment favorable to tumor growth. In a study performed at the Oslo University Hospital, Norway, Charlotte Vaysse and col...
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Nature Portfolio
2017
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oai:doaj.org-article:045a3e07f5bb4997944b6fb14b7e6c932021-12-02T12:30:15ZInflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer10.1038/s41523-017-0015-92374-4677https://doaj.org/article/045a3e07f5bb4997944b6fb14b7e6c932017-05-01T00:00:00Zhttps://doi.org/10.1038/s41523-017-0015-9https://doaj.org/toc/2374-4677Immunology: Weight tied to inflammation in fat surrounding tumor Overweight and obese women with breast cancer show more inflammation in their mammary fat tissue, creating an environment favorable to tumor growth. In a study performed at the Oslo University Hospital, Norway, Charlotte Vaysse and colleagues characterized the fat cells found close to the breast tumors of 107 patients with early-stage disease. The researchers showed that overweight and obese women were more likely to have clusters of pro-inflammatory macrophage cells within the fat tissue close to the tumors than normal weight women. They further divided the patients according to whether they’d gone through menopause or not, and found that body mass index was a good predictor of fat cell inflammatory status in postmenopausal women, whereas belly fat percentage was a more accurate measure for premenopausal women. The inflammation brought on by excess weight may contribute to breast cancer development and progression.Charlotte VaysseJon LømoØystein GarredFrøydis FjeldheimTrygve LofteroedEllen SchlichtingAnne McTiernanHanne FrydenbergAnders HusøySteinar LundgrenMorten W. FagerlandElin RichardsenErik A. WistCatherine MullerInger ThuneNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 3, Iss 1, Pp 1-10 (2017) |
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Charlotte Vaysse Jon Lømo Øystein Garred Frøydis Fjeldheim Trygve Lofteroed Ellen Schlichting Anne McTiernan Hanne Frydenberg Anders Husøy Steinar Lundgren Morten W. Fagerland Elin Richardsen Erik A. Wist Catherine Muller Inger Thune Inflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer |
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Immunology: Weight tied to inflammation in fat surrounding tumor Overweight and obese women with breast cancer show more inflammation in their mammary fat tissue, creating an environment favorable to tumor growth. In a study performed at the Oslo University Hospital, Norway, Charlotte Vaysse and colleagues characterized the fat cells found close to the breast tumors of 107 patients with early-stage disease. The researchers showed that overweight and obese women were more likely to have clusters of pro-inflammatory macrophage cells within the fat tissue close to the tumors than normal weight women. They further divided the patients according to whether they’d gone through menopause or not, and found that body mass index was a good predictor of fat cell inflammatory status in postmenopausal women, whereas belly fat percentage was a more accurate measure for premenopausal women. The inflammation brought on by excess weight may contribute to breast cancer development and progression. |
format |
article |
author |
Charlotte Vaysse Jon Lømo Øystein Garred Frøydis Fjeldheim Trygve Lofteroed Ellen Schlichting Anne McTiernan Hanne Frydenberg Anders Husøy Steinar Lundgren Morten W. Fagerland Elin Richardsen Erik A. Wist Catherine Muller Inger Thune |
author_facet |
Charlotte Vaysse Jon Lømo Øystein Garred Frøydis Fjeldheim Trygve Lofteroed Ellen Schlichting Anne McTiernan Hanne Frydenberg Anders Husøy Steinar Lundgren Morten W. Fagerland Elin Richardsen Erik A. Wist Catherine Muller Inger Thune |
author_sort |
Charlotte Vaysse |
title |
Inflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer |
title_short |
Inflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer |
title_full |
Inflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer |
title_fullStr |
Inflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer |
title_full_unstemmed |
Inflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer |
title_sort |
inflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/045a3e07f5bb4997944b6fb14b7e6c93 |
work_keys_str_mv |
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