Inflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer

Immunology: Weight tied to inflammation in fat surrounding tumor Overweight and obese women with breast cancer show more inflammation in their mammary fat tissue, creating an environment favorable to tumor growth. In a study performed at the Oslo University Hospital, Norway, Charlotte Vaysse and col...

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Autores principales: Charlotte Vaysse, Jon Lømo, Øystein Garred, Frøydis Fjeldheim, Trygve Lofteroed, Ellen Schlichting, Anne McTiernan, Hanne Frydenberg, Anders Husøy, Steinar Lundgren, Morten W. Fagerland, Elin Richardsen, Erik A. Wist, Catherine Muller, Inger Thune
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/045a3e07f5bb4997944b6fb14b7e6c93
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spelling oai:doaj.org-article:045a3e07f5bb4997944b6fb14b7e6c932021-12-02T12:30:15ZInflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer10.1038/s41523-017-0015-92374-4677https://doaj.org/article/045a3e07f5bb4997944b6fb14b7e6c932017-05-01T00:00:00Zhttps://doi.org/10.1038/s41523-017-0015-9https://doaj.org/toc/2374-4677Immunology: Weight tied to inflammation in fat surrounding tumor Overweight and obese women with breast cancer show more inflammation in their mammary fat tissue, creating an environment favorable to tumor growth. In a study performed at the Oslo University Hospital, Norway, Charlotte Vaysse and colleagues characterized the fat cells found close to the breast tumors of 107 patients with early-stage disease. The researchers showed that overweight and obese women were more likely to have clusters of pro-inflammatory macrophage cells within the fat tissue close to the tumors than normal weight women. They further divided the patients according to whether they’d gone through menopause or not, and found that body mass index was a good predictor of fat cell inflammatory status in postmenopausal women, whereas belly fat percentage was a more accurate measure for premenopausal women. The inflammation brought on by excess weight may contribute to breast cancer development and progression.Charlotte VaysseJon LømoØystein GarredFrøydis FjeldheimTrygve LofteroedEllen SchlichtingAnne McTiernanHanne FrydenbergAnders HusøySteinar LundgrenMorten W. FagerlandElin RichardsenErik A. WistCatherine MullerInger ThuneNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 3, Iss 1, Pp 1-10 (2017)
institution DOAJ
collection DOAJ
language EN
topic Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
spellingShingle Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Charlotte Vaysse
Jon Lømo
Øystein Garred
Frøydis Fjeldheim
Trygve Lofteroed
Ellen Schlichting
Anne McTiernan
Hanne Frydenberg
Anders Husøy
Steinar Lundgren
Morten W. Fagerland
Elin Richardsen
Erik A. Wist
Catherine Muller
Inger Thune
Inflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer
description Immunology: Weight tied to inflammation in fat surrounding tumor Overweight and obese women with breast cancer show more inflammation in their mammary fat tissue, creating an environment favorable to tumor growth. In a study performed at the Oslo University Hospital, Norway, Charlotte Vaysse and colleagues characterized the fat cells found close to the breast tumors of 107 patients with early-stage disease. The researchers showed that overweight and obese women were more likely to have clusters of pro-inflammatory macrophage cells within the fat tissue close to the tumors than normal weight women. They further divided the patients according to whether they’d gone through menopause or not, and found that body mass index was a good predictor of fat cell inflammatory status in postmenopausal women, whereas belly fat percentage was a more accurate measure for premenopausal women. The inflammation brought on by excess weight may contribute to breast cancer development and progression.
format article
author Charlotte Vaysse
Jon Lømo
Øystein Garred
Frøydis Fjeldheim
Trygve Lofteroed
Ellen Schlichting
Anne McTiernan
Hanne Frydenberg
Anders Husøy
Steinar Lundgren
Morten W. Fagerland
Elin Richardsen
Erik A. Wist
Catherine Muller
Inger Thune
author_facet Charlotte Vaysse
Jon Lømo
Øystein Garred
Frøydis Fjeldheim
Trygve Lofteroed
Ellen Schlichting
Anne McTiernan
Hanne Frydenberg
Anders Husøy
Steinar Lundgren
Morten W. Fagerland
Elin Richardsen
Erik A. Wist
Catherine Muller
Inger Thune
author_sort Charlotte Vaysse
title Inflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer
title_short Inflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer
title_full Inflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer
title_fullStr Inflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer
title_full_unstemmed Inflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer
title_sort inflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/045a3e07f5bb4997944b6fb14b7e6c93
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