Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis.

<h4>Objective</h4>To determine the effect of Ashwagandha extract on sleep.<h4>Methods</h4>A comprehensive search was conducted in CENTRAL, MEDLINE, SCOPUS, Google Scholars, World Health Organization Trials Portal, ClinicalTrials.gov, Clinical Trial Registry of India, and AYUS...

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Autores principales:	Kae Ling Cheah, Mohd Noor Norhayati, Lili Husniati Yaacob, Razlina Abdul Rahman
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/045a897c2d174ebda9c3b1c622383cc9
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id	oai:doaj.org-article:045a897c2d174ebda9c3b1c622383cc9
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spelling	oai:doaj.org-article:045a897c2d174ebda9c3b1c622383cc92021-12-02T20:14:10ZEffect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis.1932-620310.1371/journal.pone.0257843https://doaj.org/article/045a897c2d174ebda9c3b1c622383cc92021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257843https://doaj.org/toc/1932-6203<h4>Objective</h4>To determine the effect of Ashwagandha extract on sleep.<h4>Methods</h4>A comprehensive search was conducted in CENTRAL, MEDLINE, SCOPUS, Google Scholars, World Health Organization Trials Portal, ClinicalTrials.gov, Clinical Trial Registry of India, and AYUSH Research Portal for all appropriate trials. Randomized controlled trials that examined the effect of Ashwagandha extract versus placebo on sleep in human participants 18 years old and above were considered. Two authors independently read all trials and independently extracted all relevant data. The primary outcomes were sleep quantity and sleep quality. The secondary outcomes were mental alertness on rising, anxiety level, and quality of life.<h4>Results</h4>A total of five randomized controlled trials containing 400 participants were analyzed. Ashwagandha extract exhibited a small but significant effect on overall sleep (Standardized Mean Difference -0.59; 95% Confidence Interval -0.75 to -0.42; I2 = 62%). The effects on sleep were more prominent in the subgroup of adults diagnosed with insomnia, treatment dosage ≥600 mg/day, and treatment duration ≥8 weeks. Ashwagandha extract was also found to improve mental alertness on rising and anxiety level, but no significant effect on quality of life. No serious side effects were reported.<h4>Conclusion</h4>Ashwagandha extract appears to has a beneficial effect in improving sleep in adults. However, data on the serious adverse effects of Ashwagandha extract are limited, and more safety data would be needed to assess whether it would be safe for long-term use.Kae Ling CheahMohd Noor NorhayatiLili Husniati YaacobRazlina Abdul RahmanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257843 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kae Ling Cheah Mohd Noor Norhayati Lili Husniati Yaacob Razlina Abdul Rahman Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis.
description	<h4>Objective</h4>To determine the effect of Ashwagandha extract on sleep.<h4>Methods</h4>A comprehensive search was conducted in CENTRAL, MEDLINE, SCOPUS, Google Scholars, World Health Organization Trials Portal, ClinicalTrials.gov, Clinical Trial Registry of India, and AYUSH Research Portal for all appropriate trials. Randomized controlled trials that examined the effect of Ashwagandha extract versus placebo on sleep in human participants 18 years old and above were considered. Two authors independently read all trials and independently extracted all relevant data. The primary outcomes were sleep quantity and sleep quality. The secondary outcomes were mental alertness on rising, anxiety level, and quality of life.<h4>Results</h4>A total of five randomized controlled trials containing 400 participants were analyzed. Ashwagandha extract exhibited a small but significant effect on overall sleep (Standardized Mean Difference -0.59; 95% Confidence Interval -0.75 to -0.42; I2 = 62%). The effects on sleep were more prominent in the subgroup of adults diagnosed with insomnia, treatment dosage ≥600 mg/day, and treatment duration ≥8 weeks. Ashwagandha extract was also found to improve mental alertness on rising and anxiety level, but no significant effect on quality of life. No serious side effects were reported.<h4>Conclusion</h4>Ashwagandha extract appears to has a beneficial effect in improving sleep in adults. However, data on the serious adverse effects of Ashwagandha extract are limited, and more safety data would be needed to assess whether it would be safe for long-term use.
format	article
author	Kae Ling Cheah Mohd Noor Norhayati Lili Husniati Yaacob Razlina Abdul Rahman
author_facet	Kae Ling Cheah Mohd Noor Norhayati Lili Husniati Yaacob Razlina Abdul Rahman
author_sort	Kae Ling Cheah
title	Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis.
title_short	Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis.
title_full	Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis.
title_fullStr	Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis.
title_full_unstemmed	Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis.
title_sort	effect of ashwagandha (withania somnifera) extract on sleep: a systematic review and meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/045a897c2d174ebda9c3b1c622383cc9
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Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis.

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