Neural basis of negativity bias in the perception of ambiguous facial expression

Abstract Negativity bias, which describes the tendency to interpret ambiguous stimuli or events as negative, is often observed in patients with depression and may prevent psychological well-being. Here, we used ambiguous facial stimuli, with negative (sad) and positive (happy) emotions simultaneousl...

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Autores principales:	Takehito Ito, Keita Yokokawa, Noriaki Yahata, Ayako Isato, Tetsuya Suhara, Makiko Yamada
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/045e405f60294408b790634ea29f349a
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spelling	oai:doaj.org-article:045e405f60294408b790634ea29f349a2021-12-02T11:50:56ZNeural basis of negativity bias in the perception of ambiguous facial expression10.1038/s41598-017-00502-32045-2322https://doaj.org/article/045e405f60294408b790634ea29f349a2017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00502-3https://doaj.org/toc/2045-2322Abstract Negativity bias, which describes the tendency to interpret ambiguous stimuli or events as negative, is often observed in patients with depression and may prevent psychological well-being. Here, we used ambiguous facial stimuli, with negative (sad) and positive (happy) emotions simultaneously accessible, to examine neural activation during perceptual decision-making in healthy participants. The negativity bias was positively correlated with the activity of the bilateral pregenual anterior cingulate cortex (pgACC) when ambiguous faces were perceived as sad versus happy. Additionally, the strength of the functional connectivity between the bilateral pgACC and the right dorsal ACC (dACC)/right thalamus was positively correlated with hopelessness, one of the core characteristics of depression. Given the role of the pgACC as a major site of depressive affect and the roles of the dACC and thalamus in conflict monitoring and vigilance, respectively, our results reveal valid and important neuroanatomical correlates of the association between negativity bias and hopelessness in the healthy individuals.Takehito ItoKeita YokokawaNoriaki YahataAyako IsatoTetsuya SuharaMakiko YamadaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Takehito Ito Keita Yokokawa Noriaki Yahata Ayako Isato Tetsuya Suhara Makiko Yamada Neural basis of negativity bias in the perception of ambiguous facial expression
description	Abstract Negativity bias, which describes the tendency to interpret ambiguous stimuli or events as negative, is often observed in patients with depression and may prevent psychological well-being. Here, we used ambiguous facial stimuli, with negative (sad) and positive (happy) emotions simultaneously accessible, to examine neural activation during perceptual decision-making in healthy participants. The negativity bias was positively correlated with the activity of the bilateral pregenual anterior cingulate cortex (pgACC) when ambiguous faces were perceived as sad versus happy. Additionally, the strength of the functional connectivity between the bilateral pgACC and the right dorsal ACC (dACC)/right thalamus was positively correlated with hopelessness, one of the core characteristics of depression. Given the role of the pgACC as a major site of depressive affect and the roles of the dACC and thalamus in conflict monitoring and vigilance, respectively, our results reveal valid and important neuroanatomical correlates of the association between negativity bias and hopelessness in the healthy individuals.
format	article
author	Takehito Ito Keita Yokokawa Noriaki Yahata Ayako Isato Tetsuya Suhara Makiko Yamada
author_facet	Takehito Ito Keita Yokokawa Noriaki Yahata Ayako Isato Tetsuya Suhara Makiko Yamada
author_sort	Takehito Ito
title	Neural basis of negativity bias in the perception of ambiguous facial expression
title_short	Neural basis of negativity bias in the perception of ambiguous facial expression
title_full	Neural basis of negativity bias in the perception of ambiguous facial expression
title_fullStr	Neural basis of negativity bias in the perception of ambiguous facial expression
title_full_unstemmed	Neural basis of negativity bias in the perception of ambiguous facial expression
title_sort	neural basis of negativity bias in the perception of ambiguous facial expression
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/045e405f60294408b790634ea29f349a
work_keys_str_mv	AT takehitoito neuralbasisofnegativitybiasintheperceptionofambiguousfacialexpression AT keitayokokawa neuralbasisofnegativitybiasintheperceptionofambiguousfacialexpression AT noriakiyahata neuralbasisofnegativitybiasintheperceptionofambiguousfacialexpression AT ayakoisato neuralbasisofnegativitybiasintheperceptionofambiguousfacialexpression AT tetsuyasuhara neuralbasisofnegativitybiasintheperceptionofambiguousfacialexpression AT makikoyamada neuralbasisofnegativitybiasintheperceptionofambiguousfacialexpression
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Neural basis of negativity bias in the perception of ambiguous facial expression

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