Value of Albumin-Fibrinogen Ratio and CRP-Albumin Ratio as Predictor Marker of Disease Activity in Egyptian RA Patients, Correlated with Musculoskeletal Sonography

Naglaa Afifi,1,2 Basma M Medhat,3 Amani Mohamed Abdel Ghani,4 Hend Galal eldeen Mohamed Ali Hassan,5 Mervat E Behiry2,6 1Internal Medicine and Rheumatology, Faculty of Medicine, Ain Shams University, Cairo, Egypt; 2Internal Medicine, Armed Forces College of Medicine (AFCM), Cairo, Egypt; 3Rheumatolo...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Afifi N, M Medhat B, Abdel Ghani AM, Mohamed Ali Hassan HGE, Behiry ME
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2020
Materias:
Acceso en línea:https://doaj.org/article/046124389a784d8faf5b82e8083c6800
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:046124389a784d8faf5b82e8083c6800
record_format dspace
spelling oai:doaj.org-article:046124389a784d8faf5b82e8083c68002021-12-02T15:27:01ZValue of Albumin-Fibrinogen Ratio and CRP-Albumin Ratio as Predictor Marker of Disease Activity in Egyptian RA Patients, Correlated with Musculoskeletal Sonography1179-156Xhttps://doaj.org/article/046124389a784d8faf5b82e8083c68002020-11-01T00:00:00Zhttps://www.dovepress.com/value-of-albumin-fibrinogen-ratio-and-crp-albumin-ratio-as-predictor-m-peer-reviewed-article-OARRRhttps://doaj.org/toc/1179-156XNaglaa Afifi,1,2 Basma M Medhat,3 Amani Mohamed Abdel Ghani,4 Hend Galal eldeen Mohamed Ali Hassan,5 Mervat E Behiry2,6 1Internal Medicine and Rheumatology, Faculty of Medicine, Ain Shams University, Cairo, Egypt; 2Internal Medicine, Armed Forces College of Medicine (AFCM), Cairo, Egypt; 3Rheumatology and Rehabilitation, Faculty of Medicine, Cairo University, Cairo, Egypt; 4Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt; 5Radiodiagnosis, Faculty of Medicine, Ain Shams University, Cairo, Egypt; 6Internal Medicine, and Rheumatology, Faculty of Medicine, Cairo University, Cairo, EgyptCorrespondence: Naglaa Afifi Giza 12511, EgyptTel +201100097599Fax +20 26 28 884Email dr.naglaaafifi@gmail.comPurpose: To evaluate the albumin-fibrinogen ratio (AFR) and C-reactive protein-albumin ratio (CAR) as inflammatory markers in rheumatoid arthritis (RA) and to investigate their association with disease activity correlating with musculoskeletal ultrasonographic findings.Patients and Methods: A total of 125 cases of RA patients were consecutively enrolled in a multicenter cross-sectional study compared to 100 healthy controls, all subjects were investigated for fibrinogen, albumin, CRP, erythrocyte sedimentation rate, AFR, and CAR measurements. Patients’ disease activity was assessed by disease activity score (DAS28-ESR), and they were subjected to high-frequency ultrasound both in greyscale and power Doppler.Results: RA patients had lower AFR and higher CAR than those in the control group (P < 0.001). A positive correlation was demonstrated between CAR and DAS score (r=0.589, P = 0.0001), whilst there was a precise negative correlation between AFR and DAS 28-ESR (r=− 0.74, p< 0.001). ROC curve analyses revealed fibrinogen showed the best sensitivity (92.1%) for the area under the curve of 0.928, at a criterion of 2.47, while AFR has an area under the curve of 0.826 with sensitivity and specificity (86.84% and 75%, respectively) at cut-off value 1.46. Actively diseased patients had elevated CAR than those in remission (P < 0.001). Patients with synovial thickening and bone erosions had lower AFR than those without, CAR was higher in patients with power doppler changes than those without (p=0.015).Conclusion: Higher CAR and lower AFR were expressed in active RA than those in remission. CAR and AFR could be useful markers of ongoing inflammation and joint affection detected by musculoskeletal ultrasonography.Keywords: rheumatoid arthritis, albumin-fibrinogen ratio, C-reactive protein, inflammation, ultrasonographyAfifi NM Medhat BAbdel Ghani AMMohamed Ali Hassan HGEBehiry MEDove Medical Pressarticlerheumatoid arthritisalbumin- fibrinogen ratioc-reactive proteininflammationultrasonographyDiseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol Volume 12, Pp 241-248 (2020)
institution DOAJ
collection DOAJ
language EN
topic rheumatoid arthritis
albumin- fibrinogen ratio
c-reactive protein
inflammation
ultrasonography
Diseases of the musculoskeletal system
RC925-935
spellingShingle rheumatoid arthritis
albumin- fibrinogen ratio
c-reactive protein
inflammation
ultrasonography
Diseases of the musculoskeletal system
RC925-935
Afifi N
M Medhat B
Abdel Ghani AM
Mohamed Ali Hassan HGE
Behiry ME
Value of Albumin-Fibrinogen Ratio and CRP-Albumin Ratio as Predictor Marker of Disease Activity in Egyptian RA Patients, Correlated with Musculoskeletal Sonography
description Naglaa Afifi,1,2 Basma M Medhat,3 Amani Mohamed Abdel Ghani,4 Hend Galal eldeen Mohamed Ali Hassan,5 Mervat E Behiry2,6 1Internal Medicine and Rheumatology, Faculty of Medicine, Ain Shams University, Cairo, Egypt; 2Internal Medicine, Armed Forces College of Medicine (AFCM), Cairo, Egypt; 3Rheumatology and Rehabilitation, Faculty of Medicine, Cairo University, Cairo, Egypt; 4Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt; 5Radiodiagnosis, Faculty of Medicine, Ain Shams University, Cairo, Egypt; 6Internal Medicine, and Rheumatology, Faculty of Medicine, Cairo University, Cairo, EgyptCorrespondence: Naglaa Afifi Giza 12511, EgyptTel +201100097599Fax +20 26 28 884Email dr.naglaaafifi@gmail.comPurpose: To evaluate the albumin-fibrinogen ratio (AFR) and C-reactive protein-albumin ratio (CAR) as inflammatory markers in rheumatoid arthritis (RA) and to investigate their association with disease activity correlating with musculoskeletal ultrasonographic findings.Patients and Methods: A total of 125 cases of RA patients were consecutively enrolled in a multicenter cross-sectional study compared to 100 healthy controls, all subjects were investigated for fibrinogen, albumin, CRP, erythrocyte sedimentation rate, AFR, and CAR measurements. Patients’ disease activity was assessed by disease activity score (DAS28-ESR), and they were subjected to high-frequency ultrasound both in greyscale and power Doppler.Results: RA patients had lower AFR and higher CAR than those in the control group (P < 0.001). A positive correlation was demonstrated between CAR and DAS score (r=0.589, P = 0.0001), whilst there was a precise negative correlation between AFR and DAS 28-ESR (r=− 0.74, p< 0.001). ROC curve analyses revealed fibrinogen showed the best sensitivity (92.1%) for the area under the curve of 0.928, at a criterion of 2.47, while AFR has an area under the curve of 0.826 with sensitivity and specificity (86.84% and 75%, respectively) at cut-off value 1.46. Actively diseased patients had elevated CAR than those in remission (P < 0.001). Patients with synovial thickening and bone erosions had lower AFR than those without, CAR was higher in patients with power doppler changes than those without (p=0.015).Conclusion: Higher CAR and lower AFR were expressed in active RA than those in remission. CAR and AFR could be useful markers of ongoing inflammation and joint affection detected by musculoskeletal ultrasonography.Keywords: rheumatoid arthritis, albumin-fibrinogen ratio, C-reactive protein, inflammation, ultrasonography
format article
author Afifi N
M Medhat B
Abdel Ghani AM
Mohamed Ali Hassan HGE
Behiry ME
author_facet Afifi N
M Medhat B
Abdel Ghani AM
Mohamed Ali Hassan HGE
Behiry ME
author_sort Afifi N
title Value of Albumin-Fibrinogen Ratio and CRP-Albumin Ratio as Predictor Marker of Disease Activity in Egyptian RA Patients, Correlated with Musculoskeletal Sonography
title_short Value of Albumin-Fibrinogen Ratio and CRP-Albumin Ratio as Predictor Marker of Disease Activity in Egyptian RA Patients, Correlated with Musculoskeletal Sonography
title_full Value of Albumin-Fibrinogen Ratio and CRP-Albumin Ratio as Predictor Marker of Disease Activity in Egyptian RA Patients, Correlated with Musculoskeletal Sonography
title_fullStr Value of Albumin-Fibrinogen Ratio and CRP-Albumin Ratio as Predictor Marker of Disease Activity in Egyptian RA Patients, Correlated with Musculoskeletal Sonography
title_full_unstemmed Value of Albumin-Fibrinogen Ratio and CRP-Albumin Ratio as Predictor Marker of Disease Activity in Egyptian RA Patients, Correlated with Musculoskeletal Sonography
title_sort value of albumin-fibrinogen ratio and crp-albumin ratio as predictor marker of disease activity in egyptian ra patients, correlated with musculoskeletal sonography
publisher Dove Medical Press
publishDate 2020
url https://doaj.org/article/046124389a784d8faf5b82e8083c6800
work_keys_str_mv AT afifin valueofalbuminfibrinogenratioandcrpalbuminratioaspredictormarkerofdiseaseactivityinegyptianrapatientscorrelatedwithmusculoskeletalsonography
AT mmedhatb valueofalbuminfibrinogenratioandcrpalbuminratioaspredictormarkerofdiseaseactivityinegyptianrapatientscorrelatedwithmusculoskeletalsonography
AT abdelghaniam valueofalbuminfibrinogenratioandcrpalbuminratioaspredictormarkerofdiseaseactivityinegyptianrapatientscorrelatedwithmusculoskeletalsonography
AT mohamedalihassanhge valueofalbuminfibrinogenratioandcrpalbuminratioaspredictormarkerofdiseaseactivityinegyptianrapatientscorrelatedwithmusculoskeletalsonography
AT behiryme valueofalbuminfibrinogenratioandcrpalbuminratioaspredictormarkerofdiseaseactivityinegyptianrapatientscorrelatedwithmusculoskeletalsonography
_version_ 1718387184091791360