Additives Imparting Antimicrobial Properties to Acrylic Bone Cements

PMMA bone cements are mainly used to fix implanted prostheses and are introduced as a fluid mixture, which hardens over time. The problem of infected prosthesis could be solved due to the development of some new antibacterial bone cements. In this paper, we show the results obtained to develop four...

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Autores principales:	Alina Robu, Aurora Antoniac, Elena Grosu, Eugeniu Vasile, Anca Daniela Raiciu, Florin Iordache, Vasile Iulian Antoniac, Julietta V. Rau, Viktoriya G. Yankova, Lia Mara Ditu, Vicentiu Saceleanu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	PMMA bone cements peppermint essential oil silver nanoparticles gentamicin antimicrobial properties Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
Acceso en línea:	https://doaj.org/article/04636d08937a47a686b98bd69c1e00ba
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spelling	oai:doaj.org-article:04636d08937a47a686b98bd69c1e00ba2021-11-25T18:15:49ZAdditives Imparting Antimicrobial Properties to Acrylic Bone Cements10.3390/ma142270311996-1944https://doaj.org/article/04636d08937a47a686b98bd69c1e00ba2021-11-01T00:00:00Zhttps://www.mdpi.com/1996-1944/14/22/7031https://doaj.org/toc/1996-1944PMMA bone cements are mainly used to fix implanted prostheses and are introduced as a fluid mixture, which hardens over time. The problem of infected prosthesis could be solved due to the development of some new antibacterial bone cements. In this paper, we show the results obtained to develop four different modified PMMA bone cements by using antimicrobial additives, such as gentamicin, peppermint oil incorporated in hydroxyapatite, and silver nanoparticles incorporated in a ceramic glass matrix (2 and 4%). The structure and morphology of the modified bone cements were investigated by SEM and EDS. We perform experimental measurements on wettability, hydration degree, and degradation degree after immersion in simulated body fluid. The cytotoxicity was evaluated by MTT assay using the human MG-63 cell line. Antimicrobial properties were checked against standard strains <i>Staphylococcus aureus</i>, <i>Pseudomonas aeruginosa</i>, and <i>Candida albicans</i>. The addition of antimicrobial agents did not significantly affect the hydration and degradation degree. In terms of biocompatibility assessed by the MTT test, all experimental PMMA bone cements are biocompatible. The performance of bone cements with peppermint essential oil and silver nanoparticles against these two pathogens suggests that these antibacterial additives look promising to be used in clinical practice against bacterial infection.Alina RobuAurora AntoniacElena GrosuEugeniu VasileAnca Daniela RaiciuFlorin IordacheVasile Iulian AntoniacJulietta V. RauViktoriya G. YankovaLia Mara DituVicentiu SaceleanuMDPI AGarticlePMMA bone cementspeppermint essential oilsilver nanoparticlesgentamicinantimicrobial propertiesTechnologyTElectrical engineering. Electronics. Nuclear engineeringTK1-9971Engineering (General). Civil engineering (General)TA1-2040MicroscopyQH201-278.5Descriptive and experimental mechanicsQC120-168.85ENMaterials, Vol 14, Iss 7031, p 7031 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	PMMA bone cements peppermint essential oil silver nanoparticles gentamicin antimicrobial properties Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
spellingShingle	PMMA bone cements peppermint essential oil silver nanoparticles gentamicin antimicrobial properties Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85 Alina Robu Aurora Antoniac Elena Grosu Eugeniu Vasile Anca Daniela Raiciu Florin Iordache Vasile Iulian Antoniac Julietta V. Rau Viktoriya G. Yankova Lia Mara Ditu Vicentiu Saceleanu Additives Imparting Antimicrobial Properties to Acrylic Bone Cements
description	PMMA bone cements are mainly used to fix implanted prostheses and are introduced as a fluid mixture, which hardens over time. The problem of infected prosthesis could be solved due to the development of some new antibacterial bone cements. In this paper, we show the results obtained to develop four different modified PMMA bone cements by using antimicrobial additives, such as gentamicin, peppermint oil incorporated in hydroxyapatite, and silver nanoparticles incorporated in a ceramic glass matrix (2 and 4%). The structure and morphology of the modified bone cements were investigated by SEM and EDS. We perform experimental measurements on wettability, hydration degree, and degradation degree after immersion in simulated body fluid. The cytotoxicity was evaluated by MTT assay using the human MG-63 cell line. Antimicrobial properties were checked against standard strains <i>Staphylococcus aureus</i>, <i>Pseudomonas aeruginosa</i>, and <i>Candida albicans</i>. The addition of antimicrobial agents did not significantly affect the hydration and degradation degree. In terms of biocompatibility assessed by the MTT test, all experimental PMMA bone cements are biocompatible. The performance of bone cements with peppermint essential oil and silver nanoparticles against these two pathogens suggests that these antibacterial additives look promising to be used in clinical practice against bacterial infection.
format	article
author	Alina Robu Aurora Antoniac Elena Grosu Eugeniu Vasile Anca Daniela Raiciu Florin Iordache Vasile Iulian Antoniac Julietta V. Rau Viktoriya G. Yankova Lia Mara Ditu Vicentiu Saceleanu
author_facet	Alina Robu Aurora Antoniac Elena Grosu Eugeniu Vasile Anca Daniela Raiciu Florin Iordache Vasile Iulian Antoniac Julietta V. Rau Viktoriya G. Yankova Lia Mara Ditu Vicentiu Saceleanu
author_sort	Alina Robu
title	Additives Imparting Antimicrobial Properties to Acrylic Bone Cements
title_short	Additives Imparting Antimicrobial Properties to Acrylic Bone Cements
title_full	Additives Imparting Antimicrobial Properties to Acrylic Bone Cements
title_fullStr	Additives Imparting Antimicrobial Properties to Acrylic Bone Cements
title_full_unstemmed	Additives Imparting Antimicrobial Properties to Acrylic Bone Cements
title_sort	additives imparting antimicrobial properties to acrylic bone cements
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/04636d08937a47a686b98bd69c1e00ba
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Additives Imparting Antimicrobial Properties to Acrylic Bone Cements

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