Advanced nanomaterials targeting hypoxia to enhance radiotherapy

Jia Li,1–3,* Wenting Shang,2,3,* Yong Li,1,* Sirui Fu,1–3 Jie Tian,2,3 Ligong Lu1 1Zhuhai Precision Medical Center, Zhuhai People’s Hospital, Jinan University, Zhuhai, China; 2CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences...

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Autores principales:	Li J, Shang W, Li Y, Fu S, Tian J, Lu L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Hypoxia radiotherapy nanoparticle clinical translation Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0468ea77fa6b4ae9bf2abba12706e2d1
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spelling	oai:doaj.org-article:0468ea77fa6b4ae9bf2abba12706e2d12021-12-02T05:06:31ZAdvanced nanomaterials targeting hypoxia to enhance radiotherapy1178-2013https://doaj.org/article/0468ea77fa6b4ae9bf2abba12706e2d12018-10-01T00:00:00Zhttps://www.dovepress.com/advanced-nanomaterials-targeting-hypoxia-to-enhance-radiotherapy-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Jia Li,1–3,* Wenting Shang,2,3,* Yong Li,1,* Sirui Fu,1–3 Jie Tian,2,3 Ligong Lu1 1Zhuhai Precision Medical Center, Zhuhai People’s Hospital, Jinan University, Zhuhai, China; 2CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, China; 3Beijing Key Laboratory of Molecular Imaging, Beijing, China *These authors contributed equally to this work Abstract: Hypoxia within solid tumors is often responsible for the failure of radiotherapy. The development of hypoxia-targeting nanomaterials – aimed at enhancing the effect of radiotherapy by electrical or heat effects and at modulating hypoxia in the tumor microenvironment – is a promising strategy to address this issue. We provide an overview of recently developed advanced materials that potentiate radiotherapy. First, we summarize novel materials for oxygen delivery or production to modify the tumor microenvironment, thus improving the effects of ionizing radiation. Second, we present new approaches for the design of high-Z element–based multifunctional nanoplatforms to enhance radiotherapy. Third, novel drug delivery systems for hypoxic regions and hypoxia-inducible factor-1–targeted therapies are discussed. Fourth, we establish the effectiveness of X-ray- or near-infrared–responsive nanoparticles for selectively triggering therapeutic effects under hypoxic conditions. Finally, this review emphasizes the importance of research in the field of nanomedicine focused on tumor hypoxia to improve clinical outcomes. Keywords: radiotherapy, hypoxia, nanomaterials, hypoxia-inducible factor 1Li JShang WLi YFu STian JLu LDove Medical PressarticleHypoxiaradiotherapynanoparticleclinical translationMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 5925-5936 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hypoxia radiotherapy nanoparticle clinical translation Medicine (General) R5-920
spellingShingle	Hypoxia radiotherapy nanoparticle clinical translation Medicine (General) R5-920 Li J Shang W Li Y Fu S Tian J Lu L Advanced nanomaterials targeting hypoxia to enhance radiotherapy
description	Jia Li,1–3,* Wenting Shang,2,3,* Yong Li,1,* Sirui Fu,1–3 Jie Tian,2,3 Ligong Lu1 1Zhuhai Precision Medical Center, Zhuhai People’s Hospital, Jinan University, Zhuhai, China; 2CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, China; 3Beijing Key Laboratory of Molecular Imaging, Beijing, China *These authors contributed equally to this work Abstract: Hypoxia within solid tumors is often responsible for the failure of radiotherapy. The development of hypoxia-targeting nanomaterials – aimed at enhancing the effect of radiotherapy by electrical or heat effects and at modulating hypoxia in the tumor microenvironment – is a promising strategy to address this issue. We provide an overview of recently developed advanced materials that potentiate radiotherapy. First, we summarize novel materials for oxygen delivery or production to modify the tumor microenvironment, thus improving the effects of ionizing radiation. Second, we present new approaches for the design of high-Z element–based multifunctional nanoplatforms to enhance radiotherapy. Third, novel drug delivery systems for hypoxic regions and hypoxia-inducible factor-1–targeted therapies are discussed. Fourth, we establish the effectiveness of X-ray- or near-infrared–responsive nanoparticles for selectively triggering therapeutic effects under hypoxic conditions. Finally, this review emphasizes the importance of research in the field of nanomedicine focused on tumor hypoxia to improve clinical outcomes. Keywords: radiotherapy, hypoxia, nanomaterials, hypoxia-inducible factor 1
format	article
author	Li J Shang W Li Y Fu S Tian J Lu L
author_facet	Li J Shang W Li Y Fu S Tian J Lu L
author_sort	Li J
title	Advanced nanomaterials targeting hypoxia to enhance radiotherapy
title_short	Advanced nanomaterials targeting hypoxia to enhance radiotherapy
title_full	Advanced nanomaterials targeting hypoxia to enhance radiotherapy
title_fullStr	Advanced nanomaterials targeting hypoxia to enhance radiotherapy
title_full_unstemmed	Advanced nanomaterials targeting hypoxia to enhance radiotherapy
title_sort	advanced nanomaterials targeting hypoxia to enhance radiotherapy
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/0468ea77fa6b4ae9bf2abba12706e2d1
work_keys_str_mv	AT lij advancednanomaterialstargetinghypoxiatoenhanceradiotherapy AT shangw advancednanomaterialstargetinghypoxiatoenhanceradiotherapy AT liy advancednanomaterialstargetinghypoxiatoenhanceradiotherapy AT fus advancednanomaterialstargetinghypoxiatoenhanceradiotherapy AT tianj advancednanomaterialstargetinghypoxiatoenhanceradiotherapy AT lul advancednanomaterialstargetinghypoxiatoenhanceradiotherapy
_version_	1718400571554136064

Advanced nanomaterials targeting hypoxia to enhance radiotherapy

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