Cellular sequestrases maintain basal Hsp70 capacity ensuring balanced proteostasis

The sequestration of misfolded proteins into large assemblies by sequestrases is now considered as the third pillar in protein quality control besides chaperones and proteases. Here the authors characterise the functions of the sequestrases Hsp42 and Btn2 in the proteostasis network of S. cerevisiae...

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Autores principales:	Chi-ting Ho, Tomas Grousl, Oren Shatz, Areeb Jawed, Carmen Ruger-Herreros, Marije Semmelink, Regina Zahn, Karsten Richter, Bernd Bukau, Axel Mogk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/046a4baa20df4aac872c48bb40ab57d6
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spelling	oai:doaj.org-article:046a4baa20df4aac872c48bb40ab57d62021-12-02T14:38:38ZCellular sequestrases maintain basal Hsp70 capacity ensuring balanced proteostasis10.1038/s41467-019-12868-12041-1723https://doaj.org/article/046a4baa20df4aac872c48bb40ab57d62019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12868-1https://doaj.org/toc/2041-1723The sequestration of misfolded proteins into large assemblies by sequestrases is now considered as the third pillar in protein quality control besides chaperones and proteases. Here the authors characterise the functions of the sequestrases Hsp42 and Btn2 in the proteostasis network of S. cerevisiae and find that they protect cells from too exhaustive depletion of the Hsp70 system.Chi-ting HoTomas GrouslOren ShatzAreeb JawedCarmen Ruger-HerrerosMarije SemmelinkRegina ZahnKarsten RichterBernd BukauAxel MogkNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chi-ting Ho Tomas Grousl Oren Shatz Areeb Jawed Carmen Ruger-Herreros Marije Semmelink Regina Zahn Karsten Richter Bernd Bukau Axel Mogk Cellular sequestrases maintain basal Hsp70 capacity ensuring balanced proteostasis
description	The sequestration of misfolded proteins into large assemblies by sequestrases is now considered as the third pillar in protein quality control besides chaperones and proteases. Here the authors characterise the functions of the sequestrases Hsp42 and Btn2 in the proteostasis network of S. cerevisiae and find that they protect cells from too exhaustive depletion of the Hsp70 system.
format	article
author	Chi-ting Ho Tomas Grousl Oren Shatz Areeb Jawed Carmen Ruger-Herreros Marije Semmelink Regina Zahn Karsten Richter Bernd Bukau Axel Mogk
author_facet	Chi-ting Ho Tomas Grousl Oren Shatz Areeb Jawed Carmen Ruger-Herreros Marije Semmelink Regina Zahn Karsten Richter Bernd Bukau Axel Mogk
author_sort	Chi-ting Ho
title	Cellular sequestrases maintain basal Hsp70 capacity ensuring balanced proteostasis
title_short	Cellular sequestrases maintain basal Hsp70 capacity ensuring balanced proteostasis
title_full	Cellular sequestrases maintain basal Hsp70 capacity ensuring balanced proteostasis
title_fullStr	Cellular sequestrases maintain basal Hsp70 capacity ensuring balanced proteostasis
title_full_unstemmed	Cellular sequestrases maintain basal Hsp70 capacity ensuring balanced proteostasis
title_sort	cellular sequestrases maintain basal hsp70 capacity ensuring balanced proteostasis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/046a4baa20df4aac872c48bb40ab57d6
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Cellular sequestrases maintain basal Hsp70 capacity ensuring balanced proteostasis

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