Cellular sequestrases maintain basal Hsp70 capacity ensuring balanced proteostasis
The sequestration of misfolded proteins into large assemblies by sequestrases is now considered as the third pillar in protein quality control besides chaperones and proteases. Here the authors characterise the functions of the sequestrases Hsp42 and Btn2 in the proteostasis network of S. cerevisiae...
Guardado en:
Autores principales: | Chi-ting Ho, Tomas Grousl, Oren Shatz, Areeb Jawed, Carmen Ruger-Herreros, Marije Semmelink, Regina Zahn, Karsten Richter, Bernd Bukau, Axel Mogk |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
|
Materias: | |
Acceso en línea: | https://doaj.org/article/046a4baa20df4aac872c48bb40ab57d6 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Proteostasis by STUB1/HSP70 complex controls sensitivity to androgen receptor targeted therapy in advanced prostate cancer
por: Chengfei Liu, et al.
Publicado: (2018) -
Cellular proteostasis decline in human senescence
por: Karli Montague-Cardoso
Publicado: (2021) -
Functional analysis of Hsp70 inhibitors.
por: Rainer Schlecht, et al.
Publicado: (2013) -
Small heat shock proteins sequester misfolding proteins in near-native conformation for cellular protection and efficient refolding
por: Sophia Ungelenk, et al.
Publicado: (2016) -
Impaired proteostasis contributes to renal tubular dysgenesis.
por: Rita Machado de Oliveira, et al.
Publicado: (2011)