A computational approach to analyze the mechanism of action of the kinase inhibitor bafetinib.
Prediction of drug action in human cells is a major challenge in biomedical research. Additionally, there is strong interest in finding new applications for approved drugs and identifying potential side effects. We present a computational strategy to predict mechanisms, risks and potential new domai...
Saved in:
Main Authors: | Thomas R Burkard, Uwe Rix, Florian P Breitwieser, Giulio Superti-Furga, Jacques Colinge |
---|---|
Format: | article |
Language: | EN |
Published: |
Public Library of Science (PLoS)
2010
|
Subjects: | |
Online Access: | https://doaj.org/article/046b9efec40442d3a2bc8198814632cf |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
The SH2 domain regulates c-Abl kinase activation by a cyclin-like mechanism and remodulation of the hinge motion.
by: Nicole Dölker, et al.
Published: (2014) -
Combination of a proteomics approach and reengineering of meso scale network models for prediction of mode-of-action for tyrosine kinase inhibitors.
by: Stefan Balabanov, et al.
Published: (2013) -
Crystal structure of mammalian acid sphingomyelinase
by: Alexei Gorelik, et al.
Published: (2016) -
Real-World Approach for Molecular Analysis of Acquired EGFR Tyrosine Kinase Inhibitor Resistance Mechanisms in NSCLC
by: Liesbeth M. Hondelink, MD, et al.
Published: (2021) -
Functional dissection of the TBK1 molecular network.
by: Adriana Goncalves, et al.
Published: (2011)