Interactions between hyaluronic acid and CoCrMo alloy surface in simulated synovial fluids

Abstract The performance of CoCrMo alloy in orthopaedic implants may be unfavourably affected by hyaluronic acid (HA) in synovial fluid. In this study, the authors aimed to understand the interactions between HA and CoCrMo using dedicated electrochemical experiments and surface analyses. A sequence...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Simona Radice, Gretchen Tibbits, Alex Y. W. Lin, Haluk Beyenal, Markus A. Wimmer
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	biomaterials hyaluronic acid implants surface total hip replacement Biotechnology TP248.13-248.65 Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/046c70dcc996415ba9b6f7d756bc9cfc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:046c70dcc996415ba9b6f7d756bc9cfc
record_format	dspace
spelling	oai:doaj.org-article:046c70dcc996415ba9b6f7d756bc9cfc2021-11-12T15:58:04ZInteractions between hyaluronic acid and CoCrMo alloy surface in simulated synovial fluids2405-451810.1049/bsb2.12027https://doaj.org/article/046c70dcc996415ba9b6f7d756bc9cfc2021-12-01T00:00:00Zhttps://doi.org/10.1049/bsb2.12027https://doaj.org/toc/2405-4518Abstract The performance of CoCrMo alloy in orthopaedic implants may be unfavourably affected by hyaluronic acid (HA) in synovial fluid. In this study, the authors aimed to understand the interactions between HA and CoCrMo using dedicated electrochemical experiments and surface analyses. A sequence of electrochemical measurements (open‐circuit potential, linear polarization resistance, potentiodynamic and potentiostatic polarizations) was run on LC‐CoCrMo (ASTM F1537) in Dulbecco's phosphate‐buffered saline (DPBS) solution with and without HA and in DPBS mixed with newborn calf serum (NCS) and HA, partially under simultaneous recording of surface pH using custom‐made microelectrodes. Samples were analysed by optical and electron microscopy. HA had no significant impact on the corrosion potential of CoCrMo alloy (ECORR = −173 ± 8, −211 ± 16, and −254 ± 30 mVAg/AgCl, in DPBS, DPBS + HA, and DPBS + NCS + HA, respectively). Average current density values at the transpassive domain were double in DPBS compared to DPBS + HA and DPBS + NCS + HA. At potentials above +0.6 VAg/AgCl, surface pH values decreased from 7.5 to 6.5 in DPBS and from 7.5 to below 4 in DPBS + HA. In conclusion, the presence of HA did not compromise the corrosion resistance of CoCrMo alloy at free potential, but it enhanced acidic conditions at the near surface under anodic‐applied potential in the transpassive domain.Simona RadiceGretchen TibbitsAlex Y. W. LinHaluk BeyenalMarkus A. WimmerWileyarticlebiomaterialshyaluronic acidimplantssurfacetotal hip replacementBiotechnologyTP248.13-248.65BiochemistryQD415-436ENBiosurface and Biotribology, Vol 7, Iss 4, Pp 239-250 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biomaterials hyaluronic acid implants surface total hip replacement Biotechnology TP248.13-248.65 Biochemistry QD415-436
spellingShingle	biomaterials hyaluronic acid implants surface total hip replacement Biotechnology TP248.13-248.65 Biochemistry QD415-436 Simona Radice Gretchen Tibbits Alex Y. W. Lin Haluk Beyenal Markus A. Wimmer Interactions between hyaluronic acid and CoCrMo alloy surface in simulated synovial fluids
description	Abstract The performance of CoCrMo alloy in orthopaedic implants may be unfavourably affected by hyaluronic acid (HA) in synovial fluid. In this study, the authors aimed to understand the interactions between HA and CoCrMo using dedicated electrochemical experiments and surface analyses. A sequence of electrochemical measurements (open‐circuit potential, linear polarization resistance, potentiodynamic and potentiostatic polarizations) was run on LC‐CoCrMo (ASTM F1537) in Dulbecco's phosphate‐buffered saline (DPBS) solution with and without HA and in DPBS mixed with newborn calf serum (NCS) and HA, partially under simultaneous recording of surface pH using custom‐made microelectrodes. Samples were analysed by optical and electron microscopy. HA had no significant impact on the corrosion potential of CoCrMo alloy (ECORR = −173 ± 8, −211 ± 16, and −254 ± 30 mVAg/AgCl, in DPBS, DPBS + HA, and DPBS + NCS + HA, respectively). Average current density values at the transpassive domain were double in DPBS compared to DPBS + HA and DPBS + NCS + HA. At potentials above +0.6 VAg/AgCl, surface pH values decreased from 7.5 to 6.5 in DPBS and from 7.5 to below 4 in DPBS + HA. In conclusion, the presence of HA did not compromise the corrosion resistance of CoCrMo alloy at free potential, but it enhanced acidic conditions at the near surface under anodic‐applied potential in the transpassive domain.
format	article
author	Simona Radice Gretchen Tibbits Alex Y. W. Lin Haluk Beyenal Markus A. Wimmer
author_facet	Simona Radice Gretchen Tibbits Alex Y. W. Lin Haluk Beyenal Markus A. Wimmer
author_sort	Simona Radice
title	Interactions between hyaluronic acid and CoCrMo alloy surface in simulated synovial fluids
title_short	Interactions between hyaluronic acid and CoCrMo alloy surface in simulated synovial fluids
title_full	Interactions between hyaluronic acid and CoCrMo alloy surface in simulated synovial fluids
title_fullStr	Interactions between hyaluronic acid and CoCrMo alloy surface in simulated synovial fluids
title_full_unstemmed	Interactions between hyaluronic acid and CoCrMo alloy surface in simulated synovial fluids
title_sort	interactions between hyaluronic acid and cocrmo alloy surface in simulated synovial fluids
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/046c70dcc996415ba9b6f7d756bc9cfc
work_keys_str_mv	AT simonaradice interactionsbetweenhyaluronicacidandcocrmoalloysurfaceinsimulatedsynovialfluids AT gretchentibbits interactionsbetweenhyaluronicacidandcocrmoalloysurfaceinsimulatedsynovialfluids AT alexywlin interactionsbetweenhyaluronicacidandcocrmoalloysurfaceinsimulatedsynovialfluids AT halukbeyenal interactionsbetweenhyaluronicacidandcocrmoalloysurfaceinsimulatedsynovialfluids AT markusawimmer interactionsbetweenhyaluronicacidandcocrmoalloysurfaceinsimulatedsynovialfluids
_version_	1718430353207590912

Interactions between hyaluronic acid and CoCrMo alloy surface in simulated synovial fluids

Ejemplares similares