Mast Cells Resting-Related Prognostic Signature in Hepatocellular Carcinoma

The immune microenvironment of liver cancer is of great significance for the treatment of liver cancer. After evaluating the content of mast cells resting in the transcriptome data of The Cancer Genome Atlas database by CIBERSORT analysis, this study aimed to group the samples according to the conte...

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Autores principales:	Hao Zhang, Lin Sun, Xiao Hu
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/046f52986d444006a27e7b4da665ae30
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spelling	oai:doaj.org-article:046f52986d444006a27e7b4da665ae302021-11-29T00:56:57ZMast Cells Resting-Related Prognostic Signature in Hepatocellular Carcinoma1687-846910.1155/2021/4614257https://doaj.org/article/046f52986d444006a27e7b4da665ae302021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/4614257https://doaj.org/toc/1687-8469The immune microenvironment of liver cancer is of great significance for the treatment of liver cancer. After evaluating the content of mast cells resting in the transcriptome data of The Cancer Genome Atlas database by CIBERSORT analysis, this study aimed to group the samples according to the content of mast cells resting in different samples to find the differentially expressed genes in the two groups. Significant prognostic differences were found between high and low mast cells resting infiltration groups. The prognostic model was constructed according to the differentially expressed genes. The model was validated using external independent datasets. The results revealed that the constructed model was reliable. It could well distinguish the prognostic differences of patients in different characteristic groups. The high-risk group was mainly concentrated in metabolic pathways. The risk score of this model was closely related to some immune cells, immune function, and immune checkpoints. Therefore, this model may provide new ideas for immunotherapy of hepatocellular carcinoma.Hao ZhangLin SunXiao HuHindawi LimitedarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENJournal of Oncology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Hao Zhang Lin Sun Xiao Hu Mast Cells Resting-Related Prognostic Signature in Hepatocellular Carcinoma
description	The immune microenvironment of liver cancer is of great significance for the treatment of liver cancer. After evaluating the content of mast cells resting in the transcriptome data of The Cancer Genome Atlas database by CIBERSORT analysis, this study aimed to group the samples according to the content of mast cells resting in different samples to find the differentially expressed genes in the two groups. Significant prognostic differences were found between high and low mast cells resting infiltration groups. The prognostic model was constructed according to the differentially expressed genes. The model was validated using external independent datasets. The results revealed that the constructed model was reliable. It could well distinguish the prognostic differences of patients in different characteristic groups. The high-risk group was mainly concentrated in metabolic pathways. The risk score of this model was closely related to some immune cells, immune function, and immune checkpoints. Therefore, this model may provide new ideas for immunotherapy of hepatocellular carcinoma.
format	article
author	Hao Zhang Lin Sun Xiao Hu
author_facet	Hao Zhang Lin Sun Xiao Hu
author_sort	Hao Zhang
title	Mast Cells Resting-Related Prognostic Signature in Hepatocellular Carcinoma
title_short	Mast Cells Resting-Related Prognostic Signature in Hepatocellular Carcinoma
title_full	Mast Cells Resting-Related Prognostic Signature in Hepatocellular Carcinoma
title_fullStr	Mast Cells Resting-Related Prognostic Signature in Hepatocellular Carcinoma
title_full_unstemmed	Mast Cells Resting-Related Prognostic Signature in Hepatocellular Carcinoma
title_sort	mast cells resting-related prognostic signature in hepatocellular carcinoma
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/046f52986d444006a27e7b4da665ae30
work_keys_str_mv	AT haozhang mastcellsrestingrelatedprognosticsignatureinhepatocellularcarcinoma AT linsun mastcellsrestingrelatedprognosticsignatureinhepatocellularcarcinoma AT xiaohu mastcellsrestingrelatedprognosticsignatureinhepatocellularcarcinoma
_version_	1718407627366465536

Mast Cells Resting-Related Prognostic Signature in Hepatocellular Carcinoma

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