EVALUATION OF CYTOKINE GENE POLYMORPHISM IN B CELL LYMPHOID MALIGNANCIES

Previous studies with some solid tumors has shown that polymorphisms of certain cytokine genes may be used as predictors of clinical outcome in the patients. It seemed important to evaluate potential correlations between production of certain pro- and anti-inflammatory cytokines and co-receptor mole...

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Autores principales:	E. L. Nazarova, V. I. Shardakov, V. T. Demyanova, T. P. Zagoskina, E. N. Zotina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	b-cell lymphoid malignancies gene polymorphism cytokines cytokine receptors Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/046f9e5ebcfe404ab59b6d05332763e0
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spelling	oai:doaj.org-article:046f9e5ebcfe404ab59b6d05332763e02021-11-18T08:03:44ZEVALUATION OF CYTOKINE GENE POLYMORPHISM IN B CELL LYMPHOID MALIGNANCIES1563-06252313-741X10.15789/1563-0625-2014-5-431-436https://doaj.org/article/046f9e5ebcfe404ab59b6d05332763e02014-11-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/729https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XPrevious studies with some solid tumors has shown that polymorphisms of certain cytokine genes may be used as predictors of clinical outcome in the patients. It seemed important to evaluate potential correlations between production of certain pro- and anti-inflammatory cytokines and co-receptor molecules, and promoter polymorphism of the cytokine genes involved into regulation of cell proliferation, differentiation, apoptosis, lipid metabolism and blood clotting in the patients with hematological malignancies. The article contains our results concerning associations between of IL-1β, -2, -4, -10, -17, TNFα, and allelic polymorphisms of their genes in 62 patients with B cell lymphoid malignancies in an ethnically homogenous group (self-identified as Russians. We have shown that the GА and AA genotypes of the G-308A polymorphism in TNFα gene are significantly associated with increased production of this cytokine, being more common in aggressive non-Hodgkin lymphomas, more rare in multiple myeloma and in indolent non-Hodgkin lymphomas.E. L. NazarovaV. I. ShardakovV. T. DemyanovaT. P. ZagoskinaE. N. ZotinaSPb RAACIarticleb-cell lymphoid malignanciesgene polymorphismcytokinescytokine receptorsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 5, Pp 431-436 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	b-cell lymphoid malignancies gene polymorphism cytokines cytokine receptors Immunologic diseases. Allergy RC581-607
spellingShingle	b-cell lymphoid malignancies gene polymorphism cytokines cytokine receptors Immunologic diseases. Allergy RC581-607 E. L. Nazarova V. I. Shardakov V. T. Demyanova T. P. Zagoskina E. N. Zotina EVALUATION OF CYTOKINE GENE POLYMORPHISM IN B CELL LYMPHOID MALIGNANCIES
description	Previous studies with some solid tumors has shown that polymorphisms of certain cytokine genes may be used as predictors of clinical outcome in the patients. It seemed important to evaluate potential correlations between production of certain pro- and anti-inflammatory cytokines and co-receptor molecules, and promoter polymorphism of the cytokine genes involved into regulation of cell proliferation, differentiation, apoptosis, lipid metabolism and blood clotting in the patients with hematological malignancies. The article contains our results concerning associations between of IL-1β, -2, -4, -10, -17, TNFα, and allelic polymorphisms of their genes in 62 patients with B cell lymphoid malignancies in an ethnically homogenous group (self-identified as Russians. We have shown that the GА and AA genotypes of the G-308A polymorphism in TNFα gene are significantly associated with increased production of this cytokine, being more common in aggressive non-Hodgkin lymphomas, more rare in multiple myeloma and in indolent non-Hodgkin lymphomas.
format	article
author	E. L. Nazarova V. I. Shardakov V. T. Demyanova T. P. Zagoskina E. N. Zotina
author_facet	E. L. Nazarova V. I. Shardakov V. T. Demyanova T. P. Zagoskina E. N. Zotina
author_sort	E. L. Nazarova
title	EVALUATION OF CYTOKINE GENE POLYMORPHISM IN B CELL LYMPHOID MALIGNANCIES
title_short	EVALUATION OF CYTOKINE GENE POLYMORPHISM IN B CELL LYMPHOID MALIGNANCIES
title_full	EVALUATION OF CYTOKINE GENE POLYMORPHISM IN B CELL LYMPHOID MALIGNANCIES
title_fullStr	EVALUATION OF CYTOKINE GENE POLYMORPHISM IN B CELL LYMPHOID MALIGNANCIES
title_full_unstemmed	EVALUATION OF CYTOKINE GENE POLYMORPHISM IN B CELL LYMPHOID MALIGNANCIES
title_sort	evaluation of cytokine gene polymorphism in b cell lymphoid malignancies
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/046f9e5ebcfe404ab59b6d05332763e0
work_keys_str_mv	AT elnazarova evaluationofcytokinegenepolymorphisminbcelllymphoidmalignancies AT vishardakov evaluationofcytokinegenepolymorphisminbcelllymphoidmalignancies AT vtdemyanova evaluationofcytokinegenepolymorphisminbcelllymphoidmalignancies AT tpzagoskina evaluationofcytokinegenepolymorphisminbcelllymphoidmalignancies AT enzotina evaluationofcytokinegenepolymorphisminbcelllymphoidmalignancies
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EVALUATION OF CYTOKINE GENE POLYMORPHISM IN B CELL LYMPHOID MALIGNANCIES

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