Antimicrobial activity of cream incorporated with silver nanoparticles biosynthesized from Withania somnifera

Gregory Marslin,1 Rajendran K Selvakesavan,1 Gregory Franklin,1 Bruno Sarmento,2,3 Alberto CP Dias11Centre for the Research and Technology of Agro-Environment and Biological Sciences (CITAB-UM), AgroBioPlant Group, Department of Biology, University of Minho, Braga, Portugal; 2Instituto de Engenharia...

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Autores principales:	Marslin G, Selvakesavan RK, Franklin G, Sarmento B, Dias ACP
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/047a4785979a47389b6602a4f3dae1f7
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spelling	oai:doaj.org-article:047a4785979a47389b6602a4f3dae1f72021-12-02T02:38:19ZAntimicrobial activity of cream incorporated with silver nanoparticles biosynthesized from Withania somnifera1178-2013https://doaj.org/article/047a4785979a47389b6602a4f3dae1f72015-09-01T00:00:00Zhttps://www.dovepress.com/antimicrobial-activity-of-cream-incorporated-with-silver-nanoparticles-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Gregory Marslin,1 Rajendran K Selvakesavan,1 Gregory Franklin,1 Bruno Sarmento,2,3 Alberto CP Dias11Centre for the Research and Technology of Agro-Environment and Biological Sciences (CITAB-UM), AgroBioPlant Group, Department of Biology, University of Minho, Braga, Portugal; 2Instituto de Engenharia Biomédica (INEB), University of Porto, Porto, Portugal; 3CESPU, Instituto Universitário de Ciências da Saúde, Gandra, PortugalAbstract: We report on the antimicrobial activity of a cream formulation of silver nanoparticles (AgNPs), biosynthesized using Withania somnifera extract. Aqueous extracts of leaves promoted efficient green synthesis of AgNPs compared to fruits and root extracts of W. somnifera. Biosynthesized AgNPs were characterized for their size and shape by physical-chemical techniques such as UV-visible spectroscopy, laser Doppler anemometry, transmission electron microscopy, scanning electron microscopy, atomic force microscopy, X-ray diffraction, and X-ray energy dispersive spectroscopy. After confirming the antimicrobial potential of AgNPs, they were incorporated into a cream. Cream formulations of AgNPs and AgNO3 were prepared and compared for their antimicrobial activity against human pathogens (Staphylococcus aureus, Pseudomonas aeruginosa, Proteus vulgaris, Escherichia coli, and Candida albicans) and a plant pathogen (Agrobacterium tumefaciens). Our results show that AgNP creams possess significantly higher antimicrobial activity against the tested organisms.Keywords: Withania somnifera, green synthesis, silver nanoparticles cream, antimicrobial activityMarslin GSelvakesavan RKFranklin GSarmento BDias ACPDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 5955-5963 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Marslin G Selvakesavan RK Franklin G Sarmento B Dias ACP Antimicrobial activity of cream incorporated with silver nanoparticles biosynthesized from Withania somnifera
description	Gregory Marslin,1 Rajendran K Selvakesavan,1 Gregory Franklin,1 Bruno Sarmento,2,3 Alberto CP Dias11Centre for the Research and Technology of Agro-Environment and Biological Sciences (CITAB-UM), AgroBioPlant Group, Department of Biology, University of Minho, Braga, Portugal; 2Instituto de Engenharia Biomédica (INEB), University of Porto, Porto, Portugal; 3CESPU, Instituto Universitário de Ciências da Saúde, Gandra, PortugalAbstract: We report on the antimicrobial activity of a cream formulation of silver nanoparticles (AgNPs), biosynthesized using Withania somnifera extract. Aqueous extracts of leaves promoted efficient green synthesis of AgNPs compared to fruits and root extracts of W. somnifera. Biosynthesized AgNPs were characterized for their size and shape by physical-chemical techniques such as UV-visible spectroscopy, laser Doppler anemometry, transmission electron microscopy, scanning electron microscopy, atomic force microscopy, X-ray diffraction, and X-ray energy dispersive spectroscopy. After confirming the antimicrobial potential of AgNPs, they were incorporated into a cream. Cream formulations of AgNPs and AgNO3 were prepared and compared for their antimicrobial activity against human pathogens (Staphylococcus aureus, Pseudomonas aeruginosa, Proteus vulgaris, Escherichia coli, and Candida albicans) and a plant pathogen (Agrobacterium tumefaciens). Our results show that AgNP creams possess significantly higher antimicrobial activity against the tested organisms.Keywords: Withania somnifera, green synthesis, silver nanoparticles cream, antimicrobial activity
format	article
author	Marslin G Selvakesavan RK Franklin G Sarmento B Dias ACP
author_facet	Marslin G Selvakesavan RK Franklin G Sarmento B Dias ACP
author_sort	Marslin G
title	Antimicrobial activity of cream incorporated with silver nanoparticles biosynthesized from Withania somnifera
title_short	Antimicrobial activity of cream incorporated with silver nanoparticles biosynthesized from Withania somnifera
title_full	Antimicrobial activity of cream incorporated with silver nanoparticles biosynthesized from Withania somnifera
title_fullStr	Antimicrobial activity of cream incorporated with silver nanoparticles biosynthesized from Withania somnifera
title_full_unstemmed	Antimicrobial activity of cream incorporated with silver nanoparticles biosynthesized from Withania somnifera
title_sort	antimicrobial activity of cream incorporated with silver nanoparticles biosynthesized from withania somnifera
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/047a4785979a47389b6602a4f3dae1f7
work_keys_str_mv	AT marsling antimicrobialactivityofcreamincorporatedwithsilvernanoparticlesbiosynthesizedfromwithaniasomnifera AT selvakesavanrk antimicrobialactivityofcreamincorporatedwithsilvernanoparticlesbiosynthesizedfromwithaniasomnifera AT frankling antimicrobialactivityofcreamincorporatedwithsilvernanoparticlesbiosynthesizedfromwithaniasomnifera AT sarmentob antimicrobialactivityofcreamincorporatedwithsilvernanoparticlesbiosynthesizedfromwithaniasomnifera AT diasacp antimicrobialactivityofcreamincorporatedwithsilvernanoparticlesbiosynthesizedfromwithaniasomnifera
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Antimicrobial activity of cream incorporated with silver nanoparticles biosynthesized from Withania somnifera

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