Regulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu

Hou et al. discover that regulatory T-cells secrete soluble fibrinogen-like protein 2 that induces endometrial macrophages to polarize towards a pro-repair phenotype through the SHP2-ERK1/2-STAT3 signaling pathway. These data provide insights into the immunology of endometriosis.

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Autores principales:	Xin-Xin Hou, Xiao-Qiu Wang, Wen-Jie Zhou, Da-Jin Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/04815f499bce480398adfd3620c36c25
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spelling	oai:doaj.org-article:04815f499bce480398adfd3620c36c252021-12-02T13:44:14ZRegulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu10.1038/s42003-021-02018-z2399-3642https://doaj.org/article/04815f499bce480398adfd3620c36c252021-04-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02018-zhttps://doaj.org/toc/2399-3642Hou et al. discover that regulatory T-cells secrete soluble fibrinogen-like protein 2 that induces endometrial macrophages to polarize towards a pro-repair phenotype through the SHP2-ERK1/2-STAT3 signaling pathway. These data provide insights into the immunology of endometriosis.Xin-Xin HouXiao-Qiu WangWen-Jie ZhouDa-Jin LiNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Xin-Xin Hou Xiao-Qiu Wang Wen-Jie Zhou Da-Jin Li Regulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu
description	Hou et al. discover that regulatory T-cells secrete soluble fibrinogen-like protein 2 that induces endometrial macrophages to polarize towards a pro-repair phenotype through the SHP2-ERK1/2-STAT3 signaling pathway. These data provide insights into the immunology of endometriosis.
format	article
author	Xin-Xin Hou Xiao-Qiu Wang Wen-Jie Zhou Da-Jin Li
author_facet	Xin-Xin Hou Xiao-Qiu Wang Wen-Jie Zhou Da-Jin Li
author_sort	Xin-Xin Hou
title	Regulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu
title_short	Regulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu
title_full	Regulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu
title_fullStr	Regulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu
title_full_unstemmed	Regulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu
title_sort	regulatory t cells induce polarization of pro-repair macrophages by secreting sfgl2 into the endometriotic milieu
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/04815f499bce480398adfd3620c36c25
work_keys_str_mv	AT xinxinhou regulatorytcellsinducepolarizationofprorepairmacrophagesbysecretingsfgl2intotheendometrioticmilieu AT xiaoqiuwang regulatorytcellsinducepolarizationofprorepairmacrophagesbysecretingsfgl2intotheendometrioticmilieu AT wenjiezhou regulatorytcellsinducepolarizationofprorepairmacrophagesbysecretingsfgl2intotheendometrioticmilieu AT dajinli regulatorytcellsinducepolarizationofprorepairmacrophagesbysecretingsfgl2intotheendometrioticmilieu
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Regulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu

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