The Pattern of Second Primary Tumours in Postmenopausal Women with Prior Breast Cancer in Western Romania: A Retrospective, Single-Institution Study

With improved survival, more patients with prior breast cancer are at risk of having a second primary cancer diagnosed. The pattern and impact of second primary cancers following breast cancer is important for overall breast cancer therapeutic management. Our study is a first analysis of the trend o...

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Autores principales:	Cristina Marinela Oprean, Larisa Maria Badau, Robert-Alexandru Han, Teodora Hoinoiu, Gabriel-Mugur Dragomir, Daciana Grujic, Tiberiu Dragomir, Alis Dema
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	second malignancies breast cancer second primary tumour sites postmenopausal status molecular subtype luminal subtype Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0483a653d2384321852fce5bbef0a655
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spelling	oai:doaj.org-article:0483a653d2384321852fce5bbef0a6552021-11-25T17:20:13ZThe Pattern of Second Primary Tumours in Postmenopausal Women with Prior Breast Cancer in Western Romania: A Retrospective, Single-Institution Study10.3390/diagnostics111119572075-4418https://doaj.org/article/0483a653d2384321852fce5bbef0a6552021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/1957https://doaj.org/toc/2075-4418With improved survival, more patients with prior breast cancer are at risk of having a second primary cancer diagnosed. The pattern and impact of second primary cancers following breast cancer is important for overall breast cancer therapeutic management. Our study is a first analysis of the trend of second primary tumours over time in terms of incidence, sites with significantly elevated risks and correlation with stage, molecular subtype and therapeutic strategies conducted in Eastern Europe in postmenopausal women with breast cancer. Patients and methods: Our study population included 28 patients with prior breast cancer (BC) and second primary tumours, which were diagnosed and treated in our Institution between 2004 and 2017. The criteria for selection were based on the completeness of the documentation of the first treatment for breast cancer, stage of disease, molecular subtype, the site of origin of the second tumours and the survival data. Results: An increased risk of second primary cancer was associated with the 51–60 years age group (53.6%), with the greater prevalence in patients living in urban environments (82.1%). The use of chemotherapy increased the risk of the occurrence of gynecological second malignancies (75%). Our study is a first analysis of the trend of second primary tumours over time in terms of identifying sites with significantly elevated risks and correlation with therapeutic strategies conducted in Eastern Europe in postmenopausal women with breast cancer. Conclusions: Our study is a first analysis of the trend of second primary tumours over time in terms of correlation with luminal subtype and stage at diagnosis of primary cancer sites with significantly elevated risks and correlation with therapeutic strategies in postmenopausal women with breast cancer conducted in Eastern Europe. The reported time from primary to second primary malignancy onset, with a significantly higher rate for postmenopausal breast cancer patients, was less than one year (50%). With the advances and wider availability of genetic testing (e.g., gene panels), patients diagnosed with multiple primaries should be increasingly investigated for an underlying cancer predisposition. Postmenopausal women with breast cancer may benefit from increased surveillance and advice to avoid second malignancies.Cristina Marinela OpreanLarisa Maria BadauRobert-Alexandru HanTeodora HoinoiuGabriel-Mugur DragomirDaciana GrujicTiberiu DragomirAlis DemaMDPI AGarticlesecond malignanciesbreast cancersecond primary tumour sitespostmenopausal statusmolecular subtypeluminal subtypeMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 1957, p 1957 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	second malignancies breast cancer second primary tumour sites postmenopausal status molecular subtype luminal subtype Medicine (General) R5-920
spellingShingle	second malignancies breast cancer second primary tumour sites postmenopausal status molecular subtype luminal subtype Medicine (General) R5-920 Cristina Marinela Oprean Larisa Maria Badau Robert-Alexandru Han Teodora Hoinoiu Gabriel-Mugur Dragomir Daciana Grujic Tiberiu Dragomir Alis Dema The Pattern of Second Primary Tumours in Postmenopausal Women with Prior Breast Cancer in Western Romania: A Retrospective, Single-Institution Study
description	With improved survival, more patients with prior breast cancer are at risk of having a second primary cancer diagnosed. The pattern and impact of second primary cancers following breast cancer is important for overall breast cancer therapeutic management. Our study is a first analysis of the trend of second primary tumours over time in terms of incidence, sites with significantly elevated risks and correlation with stage, molecular subtype and therapeutic strategies conducted in Eastern Europe in postmenopausal women with breast cancer. Patients and methods: Our study population included 28 patients with prior breast cancer (BC) and second primary tumours, which were diagnosed and treated in our Institution between 2004 and 2017. The criteria for selection were based on the completeness of the documentation of the first treatment for breast cancer, stage of disease, molecular subtype, the site of origin of the second tumours and the survival data. Results: An increased risk of second primary cancer was associated with the 51–60 years age group (53.6%), with the greater prevalence in patients living in urban environments (82.1%). The use of chemotherapy increased the risk of the occurrence of gynecological second malignancies (75%). Our study is a first analysis of the trend of second primary tumours over time in terms of identifying sites with significantly elevated risks and correlation with therapeutic strategies conducted in Eastern Europe in postmenopausal women with breast cancer. Conclusions: Our study is a first analysis of the trend of second primary tumours over time in terms of correlation with luminal subtype and stage at diagnosis of primary cancer sites with significantly elevated risks and correlation with therapeutic strategies in postmenopausal women with breast cancer conducted in Eastern Europe. The reported time from primary to second primary malignancy onset, with a significantly higher rate for postmenopausal breast cancer patients, was less than one year (50%). With the advances and wider availability of genetic testing (e.g., gene panels), patients diagnosed with multiple primaries should be increasingly investigated for an underlying cancer predisposition. Postmenopausal women with breast cancer may benefit from increased surveillance and advice to avoid second malignancies.
format	article
author	Cristina Marinela Oprean Larisa Maria Badau Robert-Alexandru Han Teodora Hoinoiu Gabriel-Mugur Dragomir Daciana Grujic Tiberiu Dragomir Alis Dema
author_facet	Cristina Marinela Oprean Larisa Maria Badau Robert-Alexandru Han Teodora Hoinoiu Gabriel-Mugur Dragomir Daciana Grujic Tiberiu Dragomir Alis Dema
author_sort	Cristina Marinela Oprean
title	The Pattern of Second Primary Tumours in Postmenopausal Women with Prior Breast Cancer in Western Romania: A Retrospective, Single-Institution Study
title_short	The Pattern of Second Primary Tumours in Postmenopausal Women with Prior Breast Cancer in Western Romania: A Retrospective, Single-Institution Study
title_full	The Pattern of Second Primary Tumours in Postmenopausal Women with Prior Breast Cancer in Western Romania: A Retrospective, Single-Institution Study
title_fullStr	The Pattern of Second Primary Tumours in Postmenopausal Women with Prior Breast Cancer in Western Romania: A Retrospective, Single-Institution Study
title_full_unstemmed	The Pattern of Second Primary Tumours in Postmenopausal Women with Prior Breast Cancer in Western Romania: A Retrospective, Single-Institution Study
title_sort	pattern of second primary tumours in postmenopausal women with prior breast cancer in western romania: a retrospective, single-institution study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0483a653d2384321852fce5bbef0a655
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The Pattern of Second Primary Tumours in Postmenopausal Women with Prior Breast Cancer in Western Romania: A Retrospective, Single-Institution Study

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