TLR2, TLR4 and the MYD88 signaling pathway are crucial for neutrophil migration in acute kidney injury induced by sepsis.

TLR2, TLR4 and the MYD88 signaling pathway are crucial for neutrophil migration in acute kidney injury induced by sepsis.

The aim of this study was to investigate the role of TLR2, TLR4 and MyD88 in sepsis-induced AKI. C57BL/6 TLR2(-/-), TLR4(-/-) and MyD88(-/-) male mice were subjected to sepsis by cecal ligation and puncture (CLP). Twenty four hours later, kidney tissue and blood samples were collected for analysis....

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Autores principales: Angela Castoldi, Tárcio Teodoro Braga, Matheus Correa-Costa, Cristhiane Fávero Aguiar, Ênio José Bassi, Reinaldo Correa-Silva, Rosa Maria Elias, Fábia Salvador, Pedro Manoel Moraes-Vieira, Marcos Antônio Cenedeze, Marlene Antônia Reis, Meire Ioshie Hiyane, Álvaro Pacheco-Silva, Giselle Martins Gonçalves, Niels Olsen Saraiva Câmara
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/0483c2a07a744bf69a5dacd09fceecaf
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