Altered asymmetries of the structural networks comprising the fronto-limbic brain circuitry of preterm infants

Abstract This study aimed to elaborate upon prior findings suggestive of the altered lateralization of structural connectivity in the developing preterm brain by using diffusion tensor imaging tractography to explore how network topological asymmetries in fronto-limbic neural circuitry are altered a...

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Autores principales:	Joo Young Lee, Yong-Ho Choi, Jong Ho Cha, Ji Young Lee, Young-Jun Lee, Bo-Hyun Kim, Il-Kewon Kim, Jong-Min Lee, Hyun Ju Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/04872a421cc44a26ade315b2a65d76ee
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spelling	oai:doaj.org-article:04872a421cc44a26ade315b2a65d76ee2021-12-02T14:12:42ZAltered asymmetries of the structural networks comprising the fronto-limbic brain circuitry of preterm infants10.1038/s41598-020-79446-02045-2322https://doaj.org/article/04872a421cc44a26ade315b2a65d76ee2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79446-0https://doaj.org/toc/2045-2322Abstract This study aimed to elaborate upon prior findings suggestive of the altered lateralization of structural connectivity in the developing preterm brain by using diffusion tensor imaging tractography to explore how network topological asymmetries in fronto-limbic neural circuitry are altered at 36–41 weeks, postmenstrual age in 64 preterm infants without severe brain injury and 33 term-born infants. We compared the pattern of structural connectivity and network lateralization of the betweenness centrality in the medial fronto-orbital gyrus, superior temporal gyrus, amygdala, and hippocampus—the structures comprising the fronto-limbic brain circuit—between preterm and term infants. Global efficiency, local efficiency, and small-world characteristics did not differ significantly between the two hemispheres in term-born infants, suggesting that integration and segregation are balanced between the left and right hemispheres. However, the preterm brain showed significantly greater leftward lateralization of small-worldness (P = 0.033); the lateralization index of the betweenness centrality revealed that the medial fronto-orbital gyrus (P = 0.008), superior temporal gyrus (P = 0.031), and hippocampus (P = 0.028) showed significantly increased leftward asymmetry in preterm infants relative to term-infants independent of sex, age at imaging, and bronchopulmonary dysplasia. The altered lateralization of fronto-limbic brain circuitry might be involved in the early development of social–emotional disorders in preterm infants.Joo Young LeeYong-Ho ChoiJong Ho ChaJi Young LeeYoung-Jun LeeBo-Hyun KimIl-Kewon KimJong-Min LeeHyun Ju LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joo Young Lee Yong-Ho Choi Jong Ho Cha Ji Young Lee Young-Jun Lee Bo-Hyun Kim Il-Kewon Kim Jong-Min Lee Hyun Ju Lee Altered asymmetries of the structural networks comprising the fronto-limbic brain circuitry of preterm infants
description	Abstract This study aimed to elaborate upon prior findings suggestive of the altered lateralization of structural connectivity in the developing preterm brain by using diffusion tensor imaging tractography to explore how network topological asymmetries in fronto-limbic neural circuitry are altered at 36–41 weeks, postmenstrual age in 64 preterm infants without severe brain injury and 33 term-born infants. We compared the pattern of structural connectivity and network lateralization of the betweenness centrality in the medial fronto-orbital gyrus, superior temporal gyrus, amygdala, and hippocampus—the structures comprising the fronto-limbic brain circuit—between preterm and term infants. Global efficiency, local efficiency, and small-world characteristics did not differ significantly between the two hemispheres in term-born infants, suggesting that integration and segregation are balanced between the left and right hemispheres. However, the preterm brain showed significantly greater leftward lateralization of small-worldness (P = 0.033); the lateralization index of the betweenness centrality revealed that the medial fronto-orbital gyrus (P = 0.008), superior temporal gyrus (P = 0.031), and hippocampus (P = 0.028) showed significantly increased leftward asymmetry in preterm infants relative to term-infants independent of sex, age at imaging, and bronchopulmonary dysplasia. The altered lateralization of fronto-limbic brain circuitry might be involved in the early development of social–emotional disorders in preterm infants.
format	article
author	Joo Young Lee Yong-Ho Choi Jong Ho Cha Ji Young Lee Young-Jun Lee Bo-Hyun Kim Il-Kewon Kim Jong-Min Lee Hyun Ju Lee
author_facet	Joo Young Lee Yong-Ho Choi Jong Ho Cha Ji Young Lee Young-Jun Lee Bo-Hyun Kim Il-Kewon Kim Jong-Min Lee Hyun Ju Lee
author_sort	Joo Young Lee
title	Altered asymmetries of the structural networks comprising the fronto-limbic brain circuitry of preterm infants
title_short	Altered asymmetries of the structural networks comprising the fronto-limbic brain circuitry of preterm infants
title_full	Altered asymmetries of the structural networks comprising the fronto-limbic brain circuitry of preterm infants
title_fullStr	Altered asymmetries of the structural networks comprising the fronto-limbic brain circuitry of preterm infants
title_full_unstemmed	Altered asymmetries of the structural networks comprising the fronto-limbic brain circuitry of preterm infants
title_sort	altered asymmetries of the structural networks comprising the fronto-limbic brain circuitry of preterm infants
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/04872a421cc44a26ade315b2a65d76ee
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Altered asymmetries of the structural networks comprising the fronto-limbic brain circuitry of preterm infants

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