Sex-specific effects of neonatal progestin receptor antagonism on juvenile social play behavior in rats

Abstract Developing mammals are exposed to progesterone through several sources; however, the role of progesterone in early development is not well understood. Males express more progestin receptors (PRs) than females within several brain regions during early postnatal life, suggesting that PRs may...

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Autor principal:	R. M. Forbes-Lorman
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Rat Sex differences Progesterone Progestin receptor (PR) Social play behavior Social discrimination Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/0487534f50ad420b955fe0674ae3f5c3
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spelling	oai:doaj.org-article:0487534f50ad420b955fe0674ae3f5c32021-11-07T12:03:58ZSex-specific effects of neonatal progestin receptor antagonism on juvenile social play behavior in rats10.1186/s12993-021-00183-z1744-9081https://doaj.org/article/0487534f50ad420b955fe0674ae3f5c32021-11-01T00:00:00Zhttps://doi.org/10.1186/s12993-021-00183-zhttps://doaj.org/toc/1744-9081Abstract Developing mammals are exposed to progesterone through several sources; however, the role of progesterone in early development is not well understood. Males express more progestin receptors (PRs) than females within several brain regions during early postnatal life, suggesting that PRs may be important for the organization of the sex differences in the brain and behavior. Indeed, previous studies showed cognitive impairments in male rats treated neonatally with a PR antagonist. In the present study, we examined the role of PRs in organizing juvenile behaviors. Social play behavior and social discrimination were examined in juvenile male and female rats that had been treated with CDB, a PR antagonist, during the first week of postnatal life. Interestingly, neonatal PR antagonism altered different juvenile behaviors in males and females. A transient disruption in PR signaling during development had no effect on social discrimination but increased play initiation and pins in females. These data suggest that PRs play an important role in the organization of sex differences in some social behaviors.R. M. Forbes-LormanBMCarticleRatSex differencesProgesteroneProgestin receptor (PR)Social play behaviorSocial discriminationNeurology. Diseases of the nervous systemRC346-429ENBehavioral and Brain Functions, Vol 17, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Rat Sex differences Progesterone Progestin receptor (PR) Social play behavior Social discrimination Neurology. Diseases of the nervous system RC346-429
spellingShingle	Rat Sex differences Progesterone Progestin receptor (PR) Social play behavior Social discrimination Neurology. Diseases of the nervous system RC346-429 R. M. Forbes-Lorman Sex-specific effects of neonatal progestin receptor antagonism on juvenile social play behavior in rats
description	Abstract Developing mammals are exposed to progesterone through several sources; however, the role of progesterone in early development is not well understood. Males express more progestin receptors (PRs) than females within several brain regions during early postnatal life, suggesting that PRs may be important for the organization of the sex differences in the brain and behavior. Indeed, previous studies showed cognitive impairments in male rats treated neonatally with a PR antagonist. In the present study, we examined the role of PRs in organizing juvenile behaviors. Social play behavior and social discrimination were examined in juvenile male and female rats that had been treated with CDB, a PR antagonist, during the first week of postnatal life. Interestingly, neonatal PR antagonism altered different juvenile behaviors in males and females. A transient disruption in PR signaling during development had no effect on social discrimination but increased play initiation and pins in females. These data suggest that PRs play an important role in the organization of sex differences in some social behaviors.
format	article
author	R. M. Forbes-Lorman
author_facet	R. M. Forbes-Lorman
author_sort	R. M. Forbes-Lorman
title	Sex-specific effects of neonatal progestin receptor antagonism on juvenile social play behavior in rats
title_short	Sex-specific effects of neonatal progestin receptor antagonism on juvenile social play behavior in rats
title_full	Sex-specific effects of neonatal progestin receptor antagonism on juvenile social play behavior in rats
title_fullStr	Sex-specific effects of neonatal progestin receptor antagonism on juvenile social play behavior in rats
title_full_unstemmed	Sex-specific effects of neonatal progestin receptor antagonism on juvenile social play behavior in rats
title_sort	sex-specific effects of neonatal progestin receptor antagonism on juvenile social play behavior in rats
publisher	BMC
publishDate	2021
url	https://doaj.org/article/0487534f50ad420b955fe0674ae3f5c3
work_keys_str_mv	AT rmforbeslorman sexspecificeffectsofneonatalprogestinreceptorantagonismonjuvenilesocialplaybehaviorinrats
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Sex-specific effects of neonatal progestin receptor antagonism on juvenile social play behavior in rats

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