Regeneration of dentin-pulp complex by using dental pulp stem cells in dog
Introduction: Although missing tooth is not life-threatening, it affects the quality of daily life. Stem cells have emerged as an important player in the generation and maintenance of many tissues. The role of scaffolds has changed from a passive carrier to a bioactive matrix, which can be used to i...
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Wolters Kluwer Medknow Publications
2021
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oai:doaj.org-article:04875d9e198142a89e51653192aa333e2021-11-12T10:10:18ZRegeneration of dentin-pulp complex by using dental pulp stem cells in dog1735-33272008-025510.4103/1735-3327.328754https://doaj.org/article/04875d9e198142a89e51653192aa333e2021-01-01T00:00:00Zhttp://www.drjjournal.net/article.asp?issn=1735-3327;year=2021;volume=18;issue=1;spage=86;epage=86;aulast=Nazhvanihttps://doaj.org/toc/1735-3327https://doaj.org/toc/2008-0255Introduction: Although missing tooth is not life-threatening, it affects the quality of daily life. Stem cells have emerged as an important player in the generation and maintenance of many tissues. The role of scaffolds has changed from a passive carrier to a bioactive matrix, which can be used to induce cellular behavior. The aim of this study was to determine the possibility of regeneration of dentin-pulp complex with dental pulp stem cells (DPSCs) in an animal model.Materials and Methods: In this animal study after extraction of DPSCs and cultivation, 10 types of scaffolds were made by using platelet-rich plasma (PRP), cancellous bone, and collagen pad. They were inserted in different parts of the dog's mouth. After the 4th month, the area was operated, and the scaffolds were removed.Results: Microscopic examination revealed no sign of cell differentiation and formation of new structures in those models which used collagen scaffolds. However, the dentin-pulp complex emerged in models that the combination of bone scaffolds and PRP or stem cells was used.Conclusion: Using bone scaffolds in combination with PRP or DPSCs to regenerate dentin-pulp complex in dog helped odontoblastic and pulpal differentiation as well as the formation of predentin and tubular dentin.Fatemeh Dehghani NazhvaniSetareh KazempourSeyed-Mojtaba HosseiniAli Dehghani NazhvaniPardis HaddadiWolters Kluwer Medknow Publicationsarticlecomplexdental pulp stem celldentindifferentiationplatelet-rich plasmapulpDentistryRK1-715ENDental Research Journal, Vol 18, Iss 1, Pp 86-86 (2021) |
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DOAJ |
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complex dental pulp stem cell dentin differentiation platelet-rich plasma pulp Dentistry RK1-715 |
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complex dental pulp stem cell dentin differentiation platelet-rich plasma pulp Dentistry RK1-715 Fatemeh Dehghani Nazhvani Setareh Kazempour Seyed-Mojtaba Hosseini Ali Dehghani Nazhvani Pardis Haddadi Regeneration of dentin-pulp complex by using dental pulp stem cells in dog |
| description |
Introduction: Although missing tooth is not life-threatening, it affects the quality of daily life. Stem cells have emerged as an important player in the generation and maintenance of many tissues. The role of scaffolds has changed from a passive carrier to a bioactive matrix, which can be used to induce cellular behavior. The aim of this study was to determine the possibility of regeneration of dentin-pulp complex with dental pulp stem cells (DPSCs) in an animal model.Materials and Methods: In this animal study after extraction of DPSCs and cultivation, 10 types of scaffolds were made by using platelet-rich plasma (PRP), cancellous bone, and collagen pad. They were inserted in different parts of the dog's mouth. After the 4th month, the area was operated, and the scaffolds were removed.Results: Microscopic examination revealed no sign of cell differentiation and formation of new structures in those models which used collagen scaffolds. However, the dentin-pulp complex emerged in models that the combination of bone scaffolds and PRP or stem cells was used.Conclusion: Using bone scaffolds in combination with PRP or DPSCs to regenerate dentin-pulp complex in dog helped odontoblastic and pulpal differentiation as well as the formation of predentin and tubular dentin. |
| format |
article |
| author |
Fatemeh Dehghani Nazhvani Setareh Kazempour Seyed-Mojtaba Hosseini Ali Dehghani Nazhvani Pardis Haddadi |
| author_facet |
Fatemeh Dehghani Nazhvani Setareh Kazempour Seyed-Mojtaba Hosseini Ali Dehghani Nazhvani Pardis Haddadi |
| author_sort |
Fatemeh Dehghani Nazhvani |
| title |
Regeneration of dentin-pulp complex by using dental pulp stem cells in dog |
| title_short |
Regeneration of dentin-pulp complex by using dental pulp stem cells in dog |
| title_full |
Regeneration of dentin-pulp complex by using dental pulp stem cells in dog |
| title_fullStr |
Regeneration of dentin-pulp complex by using dental pulp stem cells in dog |
| title_full_unstemmed |
Regeneration of dentin-pulp complex by using dental pulp stem cells in dog |
| title_sort |
regeneration of dentin-pulp complex by using dental pulp stem cells in dog |
| publisher |
Wolters Kluwer Medknow Publications |
| publishDate |
2021 |
| url |
https://doaj.org/article/04875d9e198142a89e51653192aa333e |
| work_keys_str_mv |
AT fatemehdehghaninazhvani regenerationofdentinpulpcomplexbyusingdentalpulpstemcellsindog AT setarehkazempour regenerationofdentinpulpcomplexbyusingdentalpulpstemcellsindog AT seyedmojtabahosseini regenerationofdentinpulpcomplexbyusingdentalpulpstemcellsindog AT alidehghaninazhvani regenerationofdentinpulpcomplexbyusingdentalpulpstemcellsindog AT pardishaddadi regenerationofdentinpulpcomplexbyusingdentalpulpstemcellsindog |
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1718430970546225152 |