Passing through the renal clearance barrier: toward ultrasmall sizes with stable ligands for potential clinical applications

Xiao-Dong Zhang,1 Jiang Yang,2 Sha-Sha Song,1 Wei Long,1 Jie Chen,1 Xiu Shen,1 Hao Wang,1 Yuan-Ming Sun,1 Pei-Xun Liu,1 Saijun Fan11Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, P...

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Autores principales:	Zhang XD, Yang J, Song SS, Long W, Chen J, Shen X, Wang H, Sun YM, Liu PX, Fan S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/048826a0a260448ea1cb7b46c6996da9
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spelling	oai:doaj.org-article:048826a0a260448ea1cb7b46c6996da92021-12-02T05:04:31ZPassing through the renal clearance barrier: toward ultrasmall sizes with stable ligands for potential clinical applications1178-2013https://doaj.org/article/048826a0a260448ea1cb7b46c6996da92014-04-01T00:00:00Zhttp://www.dovepress.com/passing-through-the-renal-clearance-barrier-toward-ultrasmall-sizes-wi-a16558https://doaj.org/toc/1178-2013 Xiao-Dong Zhang,1 Jiang Yang,2 Sha-Sha Song,1 Wei Long,1 Jie Chen,1 Xiu Shen,1 Hao Wang,1 Yuan-Ming Sun,1 Pei-Xun Liu,1 Saijun Fan11Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, People's Republic of China; 2Department of Biological Systems Engineering, University of Wisconsin-Madison, Madison, WI, USAAbstract: The use of nanoparticles holds promise for medical applications, such as X-ray imaging, photothermal therapy and radiotherapy. However, the in vivo toxicity of inorganic nanoparticles raises some concern regarding undesirable side effects which prevent their further medical application. Ultrasmall sub-5.5 nm particles can pass through the barrier for renal clearance, minimizing their toxicity. In this letter we address some recent interesting work regarding in vivo toxicity and renal clearance, and discuss the possible strategy of utilizing ultrasmall nanomaterials. We propose that small hydrodynamic sized nanoclusters can achieve both nontoxic and therapeutic clinical features.Keywords: in vivo clearance, gold nanoparticles, small sizeZhang XDYang JSong SSLong WChen JShen XWang HSun YMLiu PXFan SDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 2069-2072 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Zhang XD Yang J Song SS Long W Chen J Shen X Wang H Sun YM Liu PX Fan S Passing through the renal clearance barrier: toward ultrasmall sizes with stable ligands for potential clinical applications
description	Xiao-Dong Zhang,1 Jiang Yang,2 Sha-Sha Song,1 Wei Long,1 Jie Chen,1 Xiu Shen,1 Hao Wang,1 Yuan-Ming Sun,1 Pei-Xun Liu,1 Saijun Fan11Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, People's Republic of China; 2Department of Biological Systems Engineering, University of Wisconsin-Madison, Madison, WI, USAAbstract: The use of nanoparticles holds promise for medical applications, such as X-ray imaging, photothermal therapy and radiotherapy. However, the in vivo toxicity of inorganic nanoparticles raises some concern regarding undesirable side effects which prevent their further medical application. Ultrasmall sub-5.5 nm particles can pass through the barrier for renal clearance, minimizing their toxicity. In this letter we address some recent interesting work regarding in vivo toxicity and renal clearance, and discuss the possible strategy of utilizing ultrasmall nanomaterials. We propose that small hydrodynamic sized nanoclusters can achieve both nontoxic and therapeutic clinical features.Keywords: in vivo clearance, gold nanoparticles, small size
format	article
author	Zhang XD Yang J Song SS Long W Chen J Shen X Wang H Sun YM Liu PX Fan S
author_facet	Zhang XD Yang J Song SS Long W Chen J Shen X Wang H Sun YM Liu PX Fan S
author_sort	Zhang XD
title	Passing through the renal clearance barrier: toward ultrasmall sizes with stable ligands for potential clinical applications
title_short	Passing through the renal clearance barrier: toward ultrasmall sizes with stable ligands for potential clinical applications
title_full	Passing through the renal clearance barrier: toward ultrasmall sizes with stable ligands for potential clinical applications
title_fullStr	Passing through the renal clearance barrier: toward ultrasmall sizes with stable ligands for potential clinical applications
title_full_unstemmed	Passing through the renal clearance barrier: toward ultrasmall sizes with stable ligands for potential clinical applications
title_sort	passing through the renal clearance barrier: toward ultrasmall sizes with stable ligands for potential clinical applications
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/048826a0a260448ea1cb7b46c6996da9
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Passing through the renal clearance barrier: toward ultrasmall sizes with stable ligands for potential clinical applications

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