Identification of Hypoxia-Related Molecular Classification and Associated Gene Signature in Oral Squamous Cell Carcinoma

The high heterogeneity of oral squamous cell carcinoma (OSCC) is the main obstacle for individualized treatment. Recognizing the characteristics of different subtypes and investigating the promising strategies for each subclass are of great significance in precise treatment. In this study, we system...

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Autores principales:	Chen Li, Xin Chen, Xiaolin Ren, Jia-lin Chen, Hao Chen, Jing-jia Yu, Qiu-chi Ran, Shuang Kang, Xi-meng Chen, Zhen-jin Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	oral squamous cell carcinoma (OSCC) hypoxia subtyping immune microenvironment immunotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/048ae32b187941b294d967b0e620ab87
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spelling	oai:doaj.org-article:048ae32b187941b294d967b0e620ab872021-11-30T12:26:42ZIdentification of Hypoxia-Related Molecular Classification and Associated Gene Signature in Oral Squamous Cell Carcinoma2234-943X10.3389/fonc.2021.709865https://doaj.org/article/048ae32b187941b294d967b0e620ab872021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.709865/fullhttps://doaj.org/toc/2234-943XThe high heterogeneity of oral squamous cell carcinoma (OSCC) is the main obstacle for individualized treatment. Recognizing the characteristics of different subtypes and investigating the promising strategies for each subclass are of great significance in precise treatment. In this study, we systematically evaluated hypoxia-mediated patterns together with immune characteristics of 309 OSCC patients in the TCGA training set and 97 patients in the GSE41613 testing set. We further identified two different hypoxia subtypes with distinct immune microenvironment traits and provided treatment programs for the two subclasses. In order to assess hypoxia level individually, we finally constructed a hypoxia-related risk score, which could predict the clinical outcome and immunotherapy response of OSCC patients. In summary, the recognition of different hypoxia patterns and the establishment of hypoxia-related risk score might enhance our understanding of the tumor microenvironment of OSCC and provide more personalized treatment strategies in the future.Chen LiXin ChenXiaolin RenXiaolin RenJia-lin ChenHao ChenJing-jia YuQiu-chi RanShuang KangXi-meng ChenZhen-jin ZhaoFrontiers Media S.A.articleoral squamous cell carcinoma (OSCC)hypoxiasubtypingimmune microenvironmentimmunotherapyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oral squamous cell carcinoma (OSCC) hypoxia subtyping immune microenvironment immunotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	oral squamous cell carcinoma (OSCC) hypoxia subtyping immune microenvironment immunotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Chen Li Xin Chen Xiaolin Ren Xiaolin Ren Jia-lin Chen Hao Chen Jing-jia Yu Qiu-chi Ran Shuang Kang Xi-meng Chen Zhen-jin Zhao Identification of Hypoxia-Related Molecular Classification and Associated Gene Signature in Oral Squamous Cell Carcinoma
description	The high heterogeneity of oral squamous cell carcinoma (OSCC) is the main obstacle for individualized treatment. Recognizing the characteristics of different subtypes and investigating the promising strategies for each subclass are of great significance in precise treatment. In this study, we systematically evaluated hypoxia-mediated patterns together with immune characteristics of 309 OSCC patients in the TCGA training set and 97 patients in the GSE41613 testing set. We further identified two different hypoxia subtypes with distinct immune microenvironment traits and provided treatment programs for the two subclasses. In order to assess hypoxia level individually, we finally constructed a hypoxia-related risk score, which could predict the clinical outcome and immunotherapy response of OSCC patients. In summary, the recognition of different hypoxia patterns and the establishment of hypoxia-related risk score might enhance our understanding of the tumor microenvironment of OSCC and provide more personalized treatment strategies in the future.
format	article
author	Chen Li Xin Chen Xiaolin Ren Xiaolin Ren Jia-lin Chen Hao Chen Jing-jia Yu Qiu-chi Ran Shuang Kang Xi-meng Chen Zhen-jin Zhao
author_facet	Chen Li Xin Chen Xiaolin Ren Xiaolin Ren Jia-lin Chen Hao Chen Jing-jia Yu Qiu-chi Ran Shuang Kang Xi-meng Chen Zhen-jin Zhao
author_sort	Chen Li
title	Identification of Hypoxia-Related Molecular Classification and Associated Gene Signature in Oral Squamous Cell Carcinoma
title_short	Identification of Hypoxia-Related Molecular Classification and Associated Gene Signature in Oral Squamous Cell Carcinoma
title_full	Identification of Hypoxia-Related Molecular Classification and Associated Gene Signature in Oral Squamous Cell Carcinoma
title_fullStr	Identification of Hypoxia-Related Molecular Classification and Associated Gene Signature in Oral Squamous Cell Carcinoma
title_full_unstemmed	Identification of Hypoxia-Related Molecular Classification and Associated Gene Signature in Oral Squamous Cell Carcinoma
title_sort	identification of hypoxia-related molecular classification and associated gene signature in oral squamous cell carcinoma
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/048ae32b187941b294d967b0e620ab87
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Identification of Hypoxia-Related Molecular Classification and Associated Gene Signature in Oral Squamous Cell Carcinoma

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