Plasmodium vivax infection compromises reticulocyte stability

During Plasmodium intra-erythrocytic developmental, parasites compromise the structural integrity of host red-blood cells. Here, Clark et al. develop a flow cytometric osmotic stability assay to show that P. vivax infection destabilizes host reticulocytes, which are less stable than P. falciparum-in...

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Autores principales: Martha A. Clark, Usheer Kanjee, Gabriel W. Rangel, Laura Chery, Anjali Mascarenhas, Edwin Gomes, Pradipsinh K. Rathod, Carlo Brugnara, Marcelo U. Ferreira, Manoj T. Duraisingh
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/048bfeac5af7438dad7b6d45ad8104b5
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Sumario:During Plasmodium intra-erythrocytic developmental, parasites compromise the structural integrity of host red-blood cells. Here, Clark et al. develop a flow cytometric osmotic stability assay to show that P. vivax infection destabilizes host reticulocytes, which are less stable than P. falciparum-infected normocytes.