An Insertion Mutation That Distorts Antibody Binding Site Architecture Enhances Function of a Human Antibody
ABSTRACT The structural and functional significance of somatic insertions and deletions in antibody chains is unclear. Here, we demonstrate that a naturally occurring three-amino-acid insertion within the influenza virus-specific human monoclonal antibody 2D1 heavy-chain variable region reconfigures...
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| Autores principales: | , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
American Society for Microbiology
2011
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/048e786b5ef74f1bacc5e4ca0983aec7 |
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