OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo

Carbapenem-resistance in Klebsiella pneumoniae sequence type ST258 can be enhanced by modification of the porins OmpK35 and OmpK36. Here, Wong et al. solve the crystal structure of a clinical ST258 OmpK36 variant, elucidating the mechanism of resistance and consequences on pathogenicity in vivo.

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Autores principales:	Joshua L. C. Wong, Maria Romano, Louise E. Kerry, Hok-Sau Kwong, Wen-Wen Low, Stephen J. Brett, Abigail Clements, Konstantinos Beis, Gad Frankel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/048fe9334b3d4543a8b1643b71a6d1c0
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spelling	oai:doaj.org-article:048fe9334b3d4543a8b1643b71a6d1c02021-12-02T14:39:56ZOmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo10.1038/s41467-019-11756-y2041-1723https://doaj.org/article/048fe9334b3d4543a8b1643b71a6d1c02019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11756-yhttps://doaj.org/toc/2041-1723Carbapenem-resistance in Klebsiella pneumoniae sequence type ST258 can be enhanced by modification of the porins OmpK35 and OmpK36. Here, Wong et al. solve the crystal structure of a clinical ST258 OmpK36 variant, elucidating the mechanism of resistance and consequences on pathogenicity in vivo.Joshua L. C. WongMaria RomanoLouise E. KerryHok-Sau KwongWen-Wen LowStephen J. BrettAbigail ClementsKonstantinos BeisGad FrankelNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joshua L. C. Wong Maria Romano Louise E. Kerry Hok-Sau Kwong Wen-Wen Low Stephen J. Brett Abigail Clements Konstantinos Beis Gad Frankel OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo
description	Carbapenem-resistance in Klebsiella pneumoniae sequence type ST258 can be enhanced by modification of the porins OmpK35 and OmpK36. Here, Wong et al. solve the crystal structure of a clinical ST258 OmpK36 variant, elucidating the mechanism of resistance and consequences on pathogenicity in vivo.
format	article
author	Joshua L. C. Wong Maria Romano Louise E. Kerry Hok-Sau Kwong Wen-Wen Low Stephen J. Brett Abigail Clements Konstantinos Beis Gad Frankel
author_facet	Joshua L. C. Wong Maria Romano Louise E. Kerry Hok-Sau Kwong Wen-Wen Low Stephen J. Brett Abigail Clements Konstantinos Beis Gad Frankel
author_sort	Joshua L. C. Wong
title	OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo
title_short	OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo
title_full	OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo
title_fullStr	OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo
title_full_unstemmed	OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo
title_sort	ompk36-mediated carbapenem resistance attenuates st258 klebsiella pneumoniae in vivo
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/048fe9334b3d4543a8b1643b71a6d1c0
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OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo

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