OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo

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OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo

Carbapenem-resistance in Klebsiella pneumoniae sequence type ST258 can be enhanced by modification of the porins OmpK35 and OmpK36. Here, Wong et al. solve the crystal structure of a clinical ST258 OmpK36 variant, elucidating the mechanism of resistance and consequences on pathogenicity in vivo.

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Detalles Bibliográficos
Autores principales:	Joshua L. C. Wong, Maria Romano, Louise E. Kerry, Hok-Sau Kwong, Wen-Wen Low, Stephen J. Brett, Abigail Clements, Konstantinos Beis, Gad Frankel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/048fe9334b3d4543a8b1643b71a6d1c0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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