Characterization of affective lability across subgroups of psychosis spectrum disorders

Abstract Background Affective lability is elevated and associated with increased clinical burden in psychosis spectrum disorders. The extent to which the level, structure and dispersion of affective lability varies between the specific disorders included in the psychosis spectrum is however unclear....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Margrethe Collier Høegh, Ingrid Melle, Sofie R. Aminoff, Beathe Haatveit, Stine Holmstul Olsen, Idun B. Huflåtten, Torill Ueland, Trine Vik Lagerberg
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Affective lability Bipolar disorders Schizophrenia Psychosis spectrum The Affective Lability Scale-Short Form (ALS-SF) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/04909543e38c4491b59e55ea30c23328
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:04909543e38c4491b59e55ea30c23328
record_format	dspace
spelling	oai:doaj.org-article:04909543e38c4491b59e55ea30c233282021-11-08T10:44:19ZCharacterization of affective lability across subgroups of psychosis spectrum disorders10.1186/s40345-021-00238-02194-7511https://doaj.org/article/04909543e38c4491b59e55ea30c233282021-11-01T00:00:00Zhttps://doi.org/10.1186/s40345-021-00238-0https://doaj.org/toc/2194-7511Abstract Background Affective lability is elevated and associated with increased clinical burden in psychosis spectrum disorders. The extent to which the level, structure and dispersion of affective lability varies between the specific disorders included in the psychosis spectrum is however unclear. To have potential value as a treatment target, further characterization of affective lability in these populations is necessary. The main aim of our study was to investigate differences in the architecture of affective lability in different psychosis spectrum disorders, and if putative differences remained when we controlled for current symptom status. Methods Affective lability was measured with The Affective Lability Scale Short Form (ALS-SF) in participants with schizophrenia (SZ, n = 76), bipolar I disorder (BD-I, n = 105), bipolar II disorder (BD-II, n = 68) and a mixed psychosis-affective group (MP, n = 48). Multiple analyses of covariance were conducted to compare the ALS-SF total and subdimension scores of the diagnostic groups, correcting for current psychotic, affective and anxiety symptoms, substance use and sex. Double generalized linear models were performed to compare the dispersion of affective lability in the different groups. Results Overall group differences in affective lability remained significant after adjusting for covariates (p = .001). BD-II had higher affective lability compared to SZ and BD-I (p = .004), with no significant differences between SZ and BD-I. There were no significant differences in the contributions of ALS-SF dimensions to the total affective lability or in dispersion of affective lability between the groups. Conclusions This study provides the construct of affective lability in psychosis spectrum disorders with more granular details that may have implications for research and clinical care. It demonstrates that despite overlap in core symptom profiles, BD-I is more similar to SZ than it is to BD-II concerning affective lability and the BD groups should consequently be studied apart. Further, affective lability appears to be characterized by fluctuations between depressive- and other affective states across different psychosis spectrum disorders, indicating that affective lability may be related to internalizing problems in these disorders. Finally, although the level varies between groups, affective lability is evenly spread and not driven by extremes across psychosis spectrum disorders and should be assessed irrespective of diagnosis.Margrethe Collier HøeghIngrid MelleSofie R. AminoffBeathe HaatveitStine Holmstul OlsenIdun B. HuflåttenTorill UelandTrine Vik LagerbergSpringerOpenarticleAffective labilityBipolar disordersSchizophreniaPsychosis spectrumThe Affective Lability Scale-Short Form (ALS-SF)Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurophysiology and neuropsychologyQP351-495ENInternational Journal of Bipolar Disorders, Vol 9, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Affective lability Bipolar disorders Schizophrenia Psychosis spectrum The Affective Lability Scale-Short Form (ALS-SF) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	Affective lability Bipolar disorders Schizophrenia Psychosis spectrum The Affective Lability Scale-Short Form (ALS-SF) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurophysiology and neuropsychology QP351-495 Margrethe Collier Høegh Ingrid Melle Sofie R. Aminoff Beathe Haatveit Stine Holmstul Olsen Idun B. Huflåtten Torill Ueland Trine Vik Lagerberg Characterization of affective lability across subgroups of psychosis spectrum disorders
description	Abstract Background Affective lability is elevated and associated with increased clinical burden in psychosis spectrum disorders. The extent to which the level, structure and dispersion of affective lability varies between the specific disorders included in the psychosis spectrum is however unclear. To have potential value as a treatment target, further characterization of affective lability in these populations is necessary. The main aim of our study was to investigate differences in the architecture of affective lability in different psychosis spectrum disorders, and if putative differences remained when we controlled for current symptom status. Methods Affective lability was measured with The Affective Lability Scale Short Form (ALS-SF) in participants with schizophrenia (SZ, n = 76), bipolar I disorder (BD-I, n = 105), bipolar II disorder (BD-II, n = 68) and a mixed psychosis-affective group (MP, n = 48). Multiple analyses of covariance were conducted to compare the ALS-SF total and subdimension scores of the diagnostic groups, correcting for current psychotic, affective and anxiety symptoms, substance use and sex. Double generalized linear models were performed to compare the dispersion of affective lability in the different groups. Results Overall group differences in affective lability remained significant after adjusting for covariates (p = .001). BD-II had higher affective lability compared to SZ and BD-I (p = .004), with no significant differences between SZ and BD-I. There were no significant differences in the contributions of ALS-SF dimensions to the total affective lability or in dispersion of affective lability between the groups. Conclusions This study provides the construct of affective lability in psychosis spectrum disorders with more granular details that may have implications for research and clinical care. It demonstrates that despite overlap in core symptom profiles, BD-I is more similar to SZ than it is to BD-II concerning affective lability and the BD groups should consequently be studied apart. Further, affective lability appears to be characterized by fluctuations between depressive- and other affective states across different psychosis spectrum disorders, indicating that affective lability may be related to internalizing problems in these disorders. Finally, although the level varies between groups, affective lability is evenly spread and not driven by extremes across psychosis spectrum disorders and should be assessed irrespective of diagnosis.
format	article
author	Margrethe Collier Høegh Ingrid Melle Sofie R. Aminoff Beathe Haatveit Stine Holmstul Olsen Idun B. Huflåtten Torill Ueland Trine Vik Lagerberg
author_facet	Margrethe Collier Høegh Ingrid Melle Sofie R. Aminoff Beathe Haatveit Stine Holmstul Olsen Idun B. Huflåtten Torill Ueland Trine Vik Lagerberg
author_sort	Margrethe Collier Høegh
title	Characterization of affective lability across subgroups of psychosis spectrum disorders
title_short	Characterization of affective lability across subgroups of psychosis spectrum disorders
title_full	Characterization of affective lability across subgroups of psychosis spectrum disorders
title_fullStr	Characterization of affective lability across subgroups of psychosis spectrum disorders
title_full_unstemmed	Characterization of affective lability across subgroups of psychosis spectrum disorders
title_sort	characterization of affective lability across subgroups of psychosis spectrum disorders
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/04909543e38c4491b59e55ea30c23328
work_keys_str_mv	AT margrethecollierhøegh characterizationofaffectivelabilityacrosssubgroupsofpsychosisspectrumdisorders AT ingridmelle characterizationofaffectivelabilityacrosssubgroupsofpsychosisspectrumdisorders AT sofieraminoff characterizationofaffectivelabilityacrosssubgroupsofpsychosisspectrumdisorders AT beathehaatveit characterizationofaffectivelabilityacrosssubgroupsofpsychosisspectrumdisorders AT stineholmstulolsen characterizationofaffectivelabilityacrosssubgroupsofpsychosisspectrumdisorders AT idunbhuflatten characterizationofaffectivelabilityacrosssubgroupsofpsychosisspectrumdisorders AT torillueland characterizationofaffectivelabilityacrosssubgroupsofpsychosisspectrumdisorders AT trineviklagerberg characterizationofaffectivelabilityacrosssubgroupsofpsychosisspectrumdisorders
_version_	1718442585102483456

Characterization of affective lability across subgroups of psychosis spectrum disorders

Ejemplares similares