Discovery of a Novel Hepatovirus (<italic toggle="yes">Phopivirus</italic> of Seals) Related to Human Hepatitis A Virus

ABSTRACT Describing the viral diversity of wildlife can provide interesting and useful insights into the natural history of established human pathogens. In this study, we describe a previously unknown picornavirus in harbor seals (tentatively named phopivirus) that is related to human hepatitis A vi...

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Autores principales:	S. J. Anthony, J. A. St. Leger, E. Liang, A. L. Hicks, M. D. Sanchez-Leon, K. Jain, J. H. Lefkowitch, I. Navarrete-Macias, N. Knowles, T. Goldstein, K. Pugliares, H. S. Ip, T. Rowles, W. I. Lipkin
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2015
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/04916cf9b20941999a16b777c9e579f4
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spelling	oai:doaj.org-article:04916cf9b20941999a16b777c9e579f42021-11-15T15:41:25ZDiscovery of a Novel Hepatovirus (<italic toggle="yes">Phopivirus</italic> of Seals) Related to Human Hepatitis A Virus10.1128/mBio.01180-152150-7511https://doaj.org/article/04916cf9b20941999a16b777c9e579f42015-09-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01180-15https://doaj.org/toc/2150-7511ABSTRACT Describing the viral diversity of wildlife can provide interesting and useful insights into the natural history of established human pathogens. In this study, we describe a previously unknown picornavirus in harbor seals (tentatively named phopivirus) that is related to human hepatitis A virus (HAV). We show that phopivirus shares several genetic and phenotypic characteristics with HAV, including phylogenetic relatedness across the genome, a specific and seemingly quiescent tropism for hepatocytes, structural conservation in a key functional region of the type III internal ribosomal entry site (IRES), and a codon usage bias consistent with that of HAV. IMPORTANCE Hepatitis A virus (HAV) is an important viral hepatitis in humans because of the substantial number of cases each year in regions with low socioeconomic status. The origin of HAV is unknown, and no nonprimate HAV-like viruses have been described. Here, we describe the discovery of an HAV-like virus in seals. This finding suggests that the diversity and evolutionary history of these viruses might be far greater than previously thought and may provide insight into the origin and pathogenicity of HAV.S. J. AnthonyJ. A. St. LegerE. LiangA. L. HicksM. D. Sanchez-LeonK. JainJ. H. LefkowitchI. Navarrete-MaciasN. KnowlesT. GoldsteinK. PugliaresH. S. IpT. RowlesW. I. LipkinAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 6, Iss 4 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 S. J. Anthony J. A. St. Leger E. Liang A. L. Hicks M. D. Sanchez-Leon K. Jain J. H. Lefkowitch I. Navarrete-Macias N. Knowles T. Goldstein K. Pugliares H. S. Ip T. Rowles W. I. Lipkin Discovery of a Novel Hepatovirus (<italic toggle="yes">Phopivirus</italic> of Seals) Related to Human Hepatitis A Virus
description	ABSTRACT Describing the viral diversity of wildlife can provide interesting and useful insights into the natural history of established human pathogens. In this study, we describe a previously unknown picornavirus in harbor seals (tentatively named phopivirus) that is related to human hepatitis A virus (HAV). We show that phopivirus shares several genetic and phenotypic characteristics with HAV, including phylogenetic relatedness across the genome, a specific and seemingly quiescent tropism for hepatocytes, structural conservation in a key functional region of the type III internal ribosomal entry site (IRES), and a codon usage bias consistent with that of HAV. IMPORTANCE Hepatitis A virus (HAV) is an important viral hepatitis in humans because of the substantial number of cases each year in regions with low socioeconomic status. The origin of HAV is unknown, and no nonprimate HAV-like viruses have been described. Here, we describe the discovery of an HAV-like virus in seals. This finding suggests that the diversity and evolutionary history of these viruses might be far greater than previously thought and may provide insight into the origin and pathogenicity of HAV.
format	article
author	S. J. Anthony J. A. St. Leger E. Liang A. L. Hicks M. D. Sanchez-Leon K. Jain J. H. Lefkowitch I. Navarrete-Macias N. Knowles T. Goldstein K. Pugliares H. S. Ip T. Rowles W. I. Lipkin
author_facet	S. J. Anthony J. A. St. Leger E. Liang A. L. Hicks M. D. Sanchez-Leon K. Jain J. H. Lefkowitch I. Navarrete-Macias N. Knowles T. Goldstein K. Pugliares H. S. Ip T. Rowles W. I. Lipkin
author_sort	S. J. Anthony
title	Discovery of a Novel Hepatovirus (<italic toggle="yes">Phopivirus</italic> of Seals) Related to Human Hepatitis A Virus
title_short	Discovery of a Novel Hepatovirus (<italic toggle="yes">Phopivirus</italic> of Seals) Related to Human Hepatitis A Virus
title_full	Discovery of a Novel Hepatovirus (<italic toggle="yes">Phopivirus</italic> of Seals) Related to Human Hepatitis A Virus
title_fullStr	Discovery of a Novel Hepatovirus (<italic toggle="yes">Phopivirus</italic> of Seals) Related to Human Hepatitis A Virus
title_full_unstemmed	Discovery of a Novel Hepatovirus (<italic toggle="yes">Phopivirus</italic> of Seals) Related to Human Hepatitis A Virus
title_sort	discovery of a novel hepatovirus (<italic toggle="yes">phopivirus</italic> of seals) related to human hepatitis a virus
publisher	American Society for Microbiology
publishDate	2015
url	https://doaj.org/article/04916cf9b20941999a16b777c9e579f4
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Discovery of a Novel Hepatovirus (<italic toggle="yes">Phopivirus</italic> of Seals) Related to Human Hepatitis A Virus

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