Acute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for activation and repression of transcription

Acute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for activation and repression of transcription

Summary: The ARID1A subunit of SWI/SNF chromatin remodeling complexes is a potent tumor suppressor. Here, a degron is applied to detect rapid loss of chromatin accessibility at thousands of loci where ARID1A acts to generate accessible minidomains of nucleosomes. Loss of ARID1A also results in the r...

Full description

Saved in:
Bibliographic Details
Main Authors: Seraina Blümli, Nicola Wiechens, Meng-Ying Wu, Vijender Singh, Marek Gierlinski, Gabriele Schweikert, Nick Gilbert, Catherine Naughton, Ramasubramanian Sundaramoorthy, Joby Varghese, Robert Gourlay, Renata Soares, David Clark, Tom Owen-Hughes
Format: article
Language:EN
Published: Elsevier 2021
Subjects:
ARID1A
SWI/SNF
EP300
BAF
chromatin remodeling
nucleosomes
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/04921146582c4b71a0ec2443dd1ee13e
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/04921146582c4b71a0ec2443dd1ee13e

Similar Items