ANALYSIS OF POLYMORPHIC VARIANTS OF CYTOKINE GENES IN PATIENTS WITH HIV INFECTION

Abstract. A distribution mode for allelic variants of cytokine genes was evaluated in 184 patients with slow viral infections, including 97 patients with chronic herpetic infection and 87 HIV-infected patients. Using modern methods of immunogenetics, we have found that relative risks of recurrent co...

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Autores principales:	N. A. Sukhalentseva, I. O. Naslednikova, A. S. Chernov, V. I. Reshetnikov, O. I. Urazova, V. V. Novitsky, M. V. Urozaeva, E. N. Chernova, E. L. Nikulina, O. V. Voronkova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	hiv infection cytokine gene polymorphism interleukin-2 interleukin-4 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/04921a5088ab462aa05b65b7f5f2c708
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spelling	oai:doaj.org-article:04921a5088ab462aa05b65b7f5f2c7082021-11-18T08:03:41ZANALYSIS OF POLYMORPHIC VARIANTS OF CYTOKINE GENES IN PATIENTS WITH HIV INFECTION1563-06252313-741X10.15789/1563-0625-2011-1-79-82https://doaj.org/article/04921a5088ab462aa05b65b7f5f2c7082014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/420https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. A distribution mode for allelic variants of cytokine genes was evaluated in 184 patients with slow viral infections, including 97 patients with chronic herpetic infection and 87 HIV-infected patients. Using modern methods of immunogenetics, we have found that relative risks of recurrent course and poor outcome of infection are positively associated with AA promoter region genotype and AA promoter genotype of +874 A/T polymorphism in the IFNG gene. Immunogenetic factors associated with protective effect in slow virus infections, include G allele of TNFA gene (G-308A SNP), and T allele/TT genotype of promoter region in the IFNG gene (+874 A/T SNP). (Med. Immunol., 2011, vol. 13, N 1, pp 79-82)N. A. SukhalentsevaI. O. NaslednikovaA. S. ChernovV. I. ReshetnikovO. I. UrazovaV. V. NovitskyM. V. UrozaevaE. N. ChernovaE. L. NikulinaO. V. VoronkovaSPb RAACIarticlehiv infectioncytokine gene polymorphisminterleukin-2interleukin-4Immunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 1, Pp 79-82 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	hiv infection cytokine gene polymorphism interleukin-2 interleukin-4 Immunologic diseases. Allergy RC581-607
spellingShingle	hiv infection cytokine gene polymorphism interleukin-2 interleukin-4 Immunologic diseases. Allergy RC581-607 N. A. Sukhalentseva I. O. Naslednikova A. S. Chernov V. I. Reshetnikov O. I. Urazova V. V. Novitsky M. V. Urozaeva E. N. Chernova E. L. Nikulina O. V. Voronkova ANALYSIS OF POLYMORPHIC VARIANTS OF CYTOKINE GENES IN PATIENTS WITH HIV INFECTION
description	Abstract. A distribution mode for allelic variants of cytokine genes was evaluated in 184 patients with slow viral infections, including 97 patients with chronic herpetic infection and 87 HIV-infected patients. Using modern methods of immunogenetics, we have found that relative risks of recurrent course and poor outcome of infection are positively associated with AA promoter region genotype and AA promoter genotype of +874 A/T polymorphism in the IFNG gene. Immunogenetic factors associated with protective effect in slow virus infections, include G allele of TNFA gene (G-308A SNP), and T allele/TT genotype of promoter region in the IFNG gene (+874 A/T SNP). (Med. Immunol., 2011, vol. 13, N 1, pp 79-82)
format	article
author	N. A. Sukhalentseva I. O. Naslednikova A. S. Chernov V. I. Reshetnikov O. I. Urazova V. V. Novitsky M. V. Urozaeva E. N. Chernova E. L. Nikulina O. V. Voronkova
author_facet	N. A. Sukhalentseva I. O. Naslednikova A. S. Chernov V. I. Reshetnikov O. I. Urazova V. V. Novitsky M. V. Urozaeva E. N. Chernova E. L. Nikulina O. V. Voronkova
author_sort	N. A. Sukhalentseva
title	ANALYSIS OF POLYMORPHIC VARIANTS OF CYTOKINE GENES IN PATIENTS WITH HIV INFECTION
title_short	ANALYSIS OF POLYMORPHIC VARIANTS OF CYTOKINE GENES IN PATIENTS WITH HIV INFECTION
title_full	ANALYSIS OF POLYMORPHIC VARIANTS OF CYTOKINE GENES IN PATIENTS WITH HIV INFECTION
title_fullStr	ANALYSIS OF POLYMORPHIC VARIANTS OF CYTOKINE GENES IN PATIENTS WITH HIV INFECTION
title_full_unstemmed	ANALYSIS OF POLYMORPHIC VARIANTS OF CYTOKINE GENES IN PATIENTS WITH HIV INFECTION
title_sort	analysis of polymorphic variants of cytokine genes in patients with hiv infection
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/04921a5088ab462aa05b65b7f5f2c708
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ANALYSIS OF POLYMORPHIC VARIANTS OF CYTOKINE GENES IN PATIENTS WITH HIV INFECTION

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