Optic nerve magnetisation transfer ratio after acute optic neuritis predicts axonal and visual outcomes.

Magnetisation transfer ratio (MTR) can reveal the degree of proton exchange between free water and macromolecules and was suggested to be pathological informative. We aimed to investigate changes in optic nerve MTR over 12 months following acute optic neuritis (ON) and to determine whether MTR measu...

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Autores principales:	Yejun Wang, Anneke van der Walt, Mark Paine, Alexander Klistorner, Helmut Butzkueven, Gary F Egan, Trevor J Kilpatrick, Scott C Kolbe
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0492b19805b54725954a7157c4f8627b
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spelling	oai:doaj.org-article:0492b19805b54725954a7157c4f8627b2021-11-18T08:04:38ZOptic nerve magnetisation transfer ratio after acute optic neuritis predicts axonal and visual outcomes.1932-620310.1371/journal.pone.0052291https://doaj.org/article/0492b19805b54725954a7157c4f8627b2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23272235/?tool=EBIhttps://doaj.org/toc/1932-6203Magnetisation transfer ratio (MTR) can reveal the degree of proton exchange between free water and macromolecules and was suggested to be pathological informative. We aimed to investigate changes in optic nerve MTR over 12 months following acute optic neuritis (ON) and to determine whether MTR measurements can predict clinical and paraclinical outcomes at 6 and 12 months. Thirty-seven patients with acute ON were studied within 2 weeks of presentation and at 1, 3, 6 and 12 months. Assessments included optic nerve MTR, retinal nerve fibre layer (RNFL) thickness, multifocal visual evoked potential (mfVEP) amplitude and latency and high (100%) and low (2.5%) contrast letter acuity. Eleven healthy controls were scanned twice four weeks apart for comparison with patients. Patient unaffected optic nerve MTR did not significantly differ from controls at any time-point. Compared to the unaffected nerve, affected optic nerve MTR was significantly reduced at 3 months (mean percentage interocular difference = -9.24%, p = 0.01), 6 months (mean = -12.48%, p<0.0001) and 12 months (mean = -7.61%, p = 0.003). Greater reduction in MTR at 3 months in patients was associated with subsequent loss of high contrast letter acuity at 6 (ρ = 0.60, p = 0.0003) and 12 (ρ = 0.44, p = 0.009) months, low contrast letter acuity at 6 (ρ = 0.35, p = 0.047) months, and RNFL thinning at 12 (ρ = 0.35, p = 0.044) months. Stratification of individual patient MTR time courses based on flux over 12 months (stable, putative remyelination and putative degeneration) predicted RNFL thinning at 12 months (F(2,32) = 3.59, p = 0.02). In conclusion, these findings indicate that MTR flux after acute ON is predictive of axonal degeneration and visual disability outcomes.Yejun WangAnneke van der WaltMark PaineAlexander KlistornerHelmut ButzkuevenGary F EganTrevor J KilpatrickScott C KolbePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e52291 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yejun Wang Anneke van der Walt Mark Paine Alexander Klistorner Helmut Butzkueven Gary F Egan Trevor J Kilpatrick Scott C Kolbe Optic nerve magnetisation transfer ratio after acute optic neuritis predicts axonal and visual outcomes.
description	Magnetisation transfer ratio (MTR) can reveal the degree of proton exchange between free water and macromolecules and was suggested to be pathological informative. We aimed to investigate changes in optic nerve MTR over 12 months following acute optic neuritis (ON) and to determine whether MTR measurements can predict clinical and paraclinical outcomes at 6 and 12 months. Thirty-seven patients with acute ON were studied within 2 weeks of presentation and at 1, 3, 6 and 12 months. Assessments included optic nerve MTR, retinal nerve fibre layer (RNFL) thickness, multifocal visual evoked potential (mfVEP) amplitude and latency and high (100%) and low (2.5%) contrast letter acuity. Eleven healthy controls were scanned twice four weeks apart for comparison with patients. Patient unaffected optic nerve MTR did not significantly differ from controls at any time-point. Compared to the unaffected nerve, affected optic nerve MTR was significantly reduced at 3 months (mean percentage interocular difference = -9.24%, p = 0.01), 6 months (mean = -12.48%, p<0.0001) and 12 months (mean = -7.61%, p = 0.003). Greater reduction in MTR at 3 months in patients was associated with subsequent loss of high contrast letter acuity at 6 (ρ = 0.60, p = 0.0003) and 12 (ρ = 0.44, p = 0.009) months, low contrast letter acuity at 6 (ρ = 0.35, p = 0.047) months, and RNFL thinning at 12 (ρ = 0.35, p = 0.044) months. Stratification of individual patient MTR time courses based on flux over 12 months (stable, putative remyelination and putative degeneration) predicted RNFL thinning at 12 months (F(2,32) = 3.59, p = 0.02). In conclusion, these findings indicate that MTR flux after acute ON is predictive of axonal degeneration and visual disability outcomes.
format	article
author	Yejun Wang Anneke van der Walt Mark Paine Alexander Klistorner Helmut Butzkueven Gary F Egan Trevor J Kilpatrick Scott C Kolbe
author_facet	Yejun Wang Anneke van der Walt Mark Paine Alexander Klistorner Helmut Butzkueven Gary F Egan Trevor J Kilpatrick Scott C Kolbe
author_sort	Yejun Wang
title	Optic nerve magnetisation transfer ratio after acute optic neuritis predicts axonal and visual outcomes.
title_short	Optic nerve magnetisation transfer ratio after acute optic neuritis predicts axonal and visual outcomes.
title_full	Optic nerve magnetisation transfer ratio after acute optic neuritis predicts axonal and visual outcomes.
title_fullStr	Optic nerve magnetisation transfer ratio after acute optic neuritis predicts axonal and visual outcomes.
title_full_unstemmed	Optic nerve magnetisation transfer ratio after acute optic neuritis predicts axonal and visual outcomes.
title_sort	optic nerve magnetisation transfer ratio after acute optic neuritis predicts axonal and visual outcomes.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/0492b19805b54725954a7157c4f8627b
work_keys_str_mv	AT yejunwang opticnervemagnetisationtransferratioafteracuteopticneuritispredictsaxonalandvisualoutcomes AT annekevanderwalt opticnervemagnetisationtransferratioafteracuteopticneuritispredictsaxonalandvisualoutcomes AT markpaine opticnervemagnetisationtransferratioafteracuteopticneuritispredictsaxonalandvisualoutcomes AT alexanderklistorner opticnervemagnetisationtransferratioafteracuteopticneuritispredictsaxonalandvisualoutcomes AT helmutbutzkueven opticnervemagnetisationtransferratioafteracuteopticneuritispredictsaxonalandvisualoutcomes AT garyfegan opticnervemagnetisationtransferratioafteracuteopticneuritispredictsaxonalandvisualoutcomes AT trevorjkilpatrick opticnervemagnetisationtransferratioafteracuteopticneuritispredictsaxonalandvisualoutcomes AT scottckolbe opticnervemagnetisationtransferratioafteracuteopticneuritispredictsaxonalandvisualoutcomes
_version_	1718422208307527680

Optic nerve magnetisation transfer ratio after acute optic neuritis predicts axonal and visual outcomes.

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