СHANGES IN PARAMETERS OF LUMINOL-DEPENDENT AND LUCIGENIN-DEPENDENT CHEMILUMINESCENCE OF PERIPHERAL BLOOD NEUTROPHILS IN PATIENTS WITH BLADDER CANCER IN THE DISEASE DYNAMICS

The study deals with parameters of luminol-dependent and lucigenin-dependent chemiluminescence (CL) of peripheral blood neutrophils from patients with bladder cancer (BC) prior to surgical treatment. We examined sixty patients (45 to 55 years old) with advanced bladder cancer (TNM) prior to the oper...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	L. M. Kurtasova, E. V. Semenov, R. A. Zukov, E. A. Shkapova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2015
Materias:	chemiluminescence neutrophils bladder cancer Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/04986dbc2af248e0847ec30d86128a48
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:04986dbc2af248e0847ec30d86128a48
record_format	dspace
spelling	oai:doaj.org-article:04986dbc2af248e0847ec30d86128a482021-11-18T08:03:44ZСHANGES IN PARAMETERS OF LUMINOL-DEPENDENT AND LUCIGENIN-DEPENDENT CHEMILUMINESCENCE OF PERIPHERAL BLOOD NEUTROPHILS IN PATIENTS WITH BLADDER CANCER IN THE DISEASE DYNAMICS1563-06252313-741X10.15789/1563-0625-2015-2-173-178https://doaj.org/article/04986dbc2af248e0847ec30d86128a482015-04-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/836https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe study deals with parameters of luminol-dependent and lucigenin-dependent chemiluminescence (CL) of peripheral blood neutrophils from patients with bladder cancer (BC) prior to surgical treatment. We examined sixty patients (45 to 55 years old) with advanced bladder cancer (TNM) prior to the operation, and forty-six patients at 10 days after surgical treatment. A control group consisted of 56 healthy donors. Luminol-dependent and lucigenin-dependent chemiluminescence of blood neutrophils was assessed according to De Sole et al. (1983). Chemiluminescence assays of peripheral blood neutrophils from the patients with bladder cancer revealed changes in production of reactive oxygen species (ROS), both for initial stage of oxidation reaction, and total level of active oxygen radicals. We have found disturbed values of primary-to-secondary ROS ratio in the cells. In the patients with bladder cancer, some changes in oxidative metabolism of the blood neutrophils have been registered. These alterations may play an important role in promotion of potential effector cell functions, thus, probably, affecting the whole-scale development of a cytopathic effect exerted by neutrophilic granulocytes.L. M. KurtasovaE. V. SemenovR. A. ZukovE. A. ShkapovaSPb RAACIarticlechemiluminescenceneutrophilsbladder cancerImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 17, Iss 2, Pp 173-178 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	chemiluminescence neutrophils bladder cancer Immunologic diseases. Allergy RC581-607
spellingShingle	chemiluminescence neutrophils bladder cancer Immunologic diseases. Allergy RC581-607 L. M. Kurtasova E. V. Semenov R. A. Zukov E. A. Shkapova СHANGES IN PARAMETERS OF LUMINOL-DEPENDENT AND LUCIGENIN-DEPENDENT CHEMILUMINESCENCE OF PERIPHERAL BLOOD NEUTROPHILS IN PATIENTS WITH BLADDER CANCER IN THE DISEASE DYNAMICS
description	The study deals with parameters of luminol-dependent and lucigenin-dependent chemiluminescence (CL) of peripheral blood neutrophils from patients with bladder cancer (BC) prior to surgical treatment. We examined sixty patients (45 to 55 years old) with advanced bladder cancer (TNM) prior to the operation, and forty-six patients at 10 days after surgical treatment. A control group consisted of 56 healthy donors. Luminol-dependent and lucigenin-dependent chemiluminescence of blood neutrophils was assessed according to De Sole et al. (1983). Chemiluminescence assays of peripheral blood neutrophils from the patients with bladder cancer revealed changes in production of reactive oxygen species (ROS), both for initial stage of oxidation reaction, and total level of active oxygen radicals. We have found disturbed values of primary-to-secondary ROS ratio in the cells. In the patients with bladder cancer, some changes in oxidative metabolism of the blood neutrophils have been registered. These alterations may play an important role in promotion of potential effector cell functions, thus, probably, affecting the whole-scale development of a cytopathic effect exerted by neutrophilic granulocytes.
format	article
author	L. M. Kurtasova E. V. Semenov R. A. Zukov E. A. Shkapova
author_facet	L. M. Kurtasova E. V. Semenov R. A. Zukov E. A. Shkapova
author_sort	L. M. Kurtasova
title	СHANGES IN PARAMETERS OF LUMINOL-DEPENDENT AND LUCIGENIN-DEPENDENT CHEMILUMINESCENCE OF PERIPHERAL BLOOD NEUTROPHILS IN PATIENTS WITH BLADDER CANCER IN THE DISEASE DYNAMICS
title_short	СHANGES IN PARAMETERS OF LUMINOL-DEPENDENT AND LUCIGENIN-DEPENDENT CHEMILUMINESCENCE OF PERIPHERAL BLOOD NEUTROPHILS IN PATIENTS WITH BLADDER CANCER IN THE DISEASE DYNAMICS
title_full	СHANGES IN PARAMETERS OF LUMINOL-DEPENDENT AND LUCIGENIN-DEPENDENT CHEMILUMINESCENCE OF PERIPHERAL BLOOD NEUTROPHILS IN PATIENTS WITH BLADDER CANCER IN THE DISEASE DYNAMICS
title_fullStr	СHANGES IN PARAMETERS OF LUMINOL-DEPENDENT AND LUCIGENIN-DEPENDENT CHEMILUMINESCENCE OF PERIPHERAL BLOOD NEUTROPHILS IN PATIENTS WITH BLADDER CANCER IN THE DISEASE DYNAMICS
title_full_unstemmed	СHANGES IN PARAMETERS OF LUMINOL-DEPENDENT AND LUCIGENIN-DEPENDENT CHEMILUMINESCENCE OF PERIPHERAL BLOOD NEUTROPHILS IN PATIENTS WITH BLADDER CANCER IN THE DISEASE DYNAMICS
title_sort	сhanges in parameters of luminol-dependent and lucigenin-dependent chemiluminescence of peripheral blood neutrophils in patients with bladder cancer in the disease dynamics
publisher	SPb RAACI
publishDate	2015
url	https://doaj.org/article/04986dbc2af248e0847ec30d86128a48
work_keys_str_mv	AT lmkurtasova shangesinparametersofluminoldependentandlucigenindependentchemiluminescenceofperipheralbloodneutrophilsinpatientswithbladdercancerinthediseasedynamics AT evsemenov shangesinparametersofluminoldependentandlucigenindependentchemiluminescenceofperipheralbloodneutrophilsinpatientswithbladdercancerinthediseasedynamics AT razukov shangesinparametersofluminoldependentandlucigenindependentchemiluminescenceofperipheralbloodneutrophilsinpatientswithbladdercancerinthediseasedynamics AT eashkapova shangesinparametersofluminoldependentandlucigenindependentchemiluminescenceofperipheralbloodneutrophilsinpatientswithbladdercancerinthediseasedynamics
_version_	1718422394363707392

СHANGES IN PARAMETERS OF LUMINOL-DEPENDENT AND LUCIGENIN-DEPENDENT CHEMILUMINESCENCE OF PERIPHERAL BLOOD NEUTROPHILS IN PATIENTS WITH BLADDER CANCER IN THE DISEASE DYNAMICS

Ejemplares similares