Fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems

Ghulam Jalani,* Chan Woo Jung,* Jae Sang Lee, Dong Woo Lim Department of Bionano Engineering, College of Engineering Sciences, Hanyang University, Education Research Industry Cluster at Ansan Campus, Ansan, South Korea*These authors contributed equally to this workAbstract: Stimuli-responsive, poly...

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Autores principales:	Jalani G, Jung CW, Lee JS, Lim DW
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0498dd0771cc4a04ae70b3e0e719ffaa
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spelling	oai:doaj.org-article:0498dd0771cc4a04ae70b3e0e719ffaa2021-12-02T02:37:15ZFabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems1178-2013https://doaj.org/article/0498dd0771cc4a04ae70b3e0e719ffaa2014-05-01T00:00:00Zhttp://www.dovepress.com/fabrication-and-characterization-of-anisotropic-nanofiber-scaffolds-fo-a16692https://doaj.org/toc/1178-2013 Ghulam Jalani,* Chan Woo Jung,* Jae Sang Lee, Dong Woo Lim Department of Bionano Engineering, College of Engineering Sciences, Hanyang University, Education Research Industry Cluster at Ansan Campus, Ansan, South Korea*These authors contributed equally to this workAbstract: Stimuli-responsive, polymer-based nanostructures with anisotropic compartments are of great interest as advanced materials because they are capable of switching their shape via environmentally-triggered conformational changes, while maintaining discrete compartments. In this study, a new class of stimuli-responsive, anisotropic nanofiber scaffolds with physically and chemically distinct compartments was prepared via electrohydrodynamic cojetting with side-by-side needle geometry. These nanofibers have a thermally responsive, physically-crosslinked compartment, and a chemically-crosslinked compartment at the nanoscale. The thermally responsive compartment is composed of physically crosslinkable poly(N-isopropylacrylamide) poly(NIPAM) copolymers, and poly(NIPAM-co-stearyl acrylate) poly(NIPAM-co-SA), while the thermally-unresponsive compartment is composed of polyethylene glycol dimethacrylates. The two distinct compartments were physically crosslinked by the hydrophobic interaction of the stearyl chains of poly(NIPAM-co-SA) or chemically stabilized via ultraviolet irradiation, and were swollen in physiologically relevant buffers due to their hydrophilic polymer networks. Bicompartmental nanofibers with the physically-crosslinked network of the poly(NIPAM-co-SA) compartment showed a thermally-triggered shape change due to thermally-induced aggregation of poly(NIPAM-co-SA). Furthermore, when bovine serum albumin and dexamethasone phosphate were separately loaded into each compartment, the bicompartmental nanofibers with anisotropic actuation exhibited decoupled, controlled release profiles of both drugs in response to a temperature. A new class of multicompartmental nanofibers could be useful for advanced nanofiber scaffolds with two or more drugs released with different kinetics in response to environmental stimuli.Keywords: stimuli responsiveness, anisotropy, nanofibers, actuation, drug delivery, tissue engineeringJalani GJung CWLee JSLim DWDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Supplement 1, Pp 33-49 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Jalani G Jung CW Lee JS Lim DW Fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems
description	Ghulam Jalani,* Chan Woo Jung,* Jae Sang Lee, Dong Woo Lim Department of Bionano Engineering, College of Engineering Sciences, Hanyang University, Education Research Industry Cluster at Ansan Campus, Ansan, South Korea*These authors contributed equally to this workAbstract: Stimuli-responsive, polymer-based nanostructures with anisotropic compartments are of great interest as advanced materials because they are capable of switching their shape via environmentally-triggered conformational changes, while maintaining discrete compartments. In this study, a new class of stimuli-responsive, anisotropic nanofiber scaffolds with physically and chemically distinct compartments was prepared via electrohydrodynamic cojetting with side-by-side needle geometry. These nanofibers have a thermally responsive, physically-crosslinked compartment, and a chemically-crosslinked compartment at the nanoscale. The thermally responsive compartment is composed of physically crosslinkable poly(N-isopropylacrylamide) poly(NIPAM) copolymers, and poly(NIPAM-co-stearyl acrylate) poly(NIPAM-co-SA), while the thermally-unresponsive compartment is composed of polyethylene glycol dimethacrylates. The two distinct compartments were physically crosslinked by the hydrophobic interaction of the stearyl chains of poly(NIPAM-co-SA) or chemically stabilized via ultraviolet irradiation, and were swollen in physiologically relevant buffers due to their hydrophilic polymer networks. Bicompartmental nanofibers with the physically-crosslinked network of the poly(NIPAM-co-SA) compartment showed a thermally-triggered shape change due to thermally-induced aggregation of poly(NIPAM-co-SA). Furthermore, when bovine serum albumin and dexamethasone phosphate were separately loaded into each compartment, the bicompartmental nanofibers with anisotropic actuation exhibited decoupled, controlled release profiles of both drugs in response to a temperature. A new class of multicompartmental nanofibers could be useful for advanced nanofiber scaffolds with two or more drugs released with different kinetics in response to environmental stimuli.Keywords: stimuli responsiveness, anisotropy, nanofibers, actuation, drug delivery, tissue engineering
format	article
author	Jalani G Jung CW Lee JS Lim DW
author_facet	Jalani G Jung CW Lee JS Lim DW
author_sort	Jalani G
title	Fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems
title_short	Fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems
title_full	Fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems
title_fullStr	Fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems
title_full_unstemmed	Fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems
title_sort	fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/0498dd0771cc4a04ae70b3e0e719ffaa
work_keys_str_mv	AT jalanig fabricationandcharacterizationofanisotropicnanofiberscaffoldsforadvanceddrugdeliverysystems AT jungcw fabricationandcharacterizationofanisotropicnanofiberscaffoldsforadvanceddrugdeliverysystems AT leejs fabricationandcharacterizationofanisotropicnanofiberscaffoldsforadvanceddrugdeliverysystems AT limdw fabricationandcharacterizationofanisotropicnanofiberscaffoldsforadvanceddrugdeliverysystems
_version_	1718402265261277184

Fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems

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