Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele

Interleukin-7 (IL-7) is a central cytokine in T cell homeostasis. Here the authors show that allelic variation at rs6897932, an autoimmune GWAS risk allele at IL7R, regulates surface and soluble IL-7R in stimulated monocytes, indicating a function of monocytes in IL-7-related autoimmunity.

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Autores principales:	Hussein Al-Mossawi, Nicole Yager, Chelsea A. Taylor, Evelyn Lau, Sara Danielli, Jelle de Wit, James Gilchrist, Isar Nassiri, Elise A. Mahe, Wanseon Lee, Laila Rizvi, Seiko Makino, Jane Cheeseman, Matt Neville, Julian C. Knight, Paul Bowness, Benjamin P. Fairfax
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/049d83c02bd448feb336fe01a336bc58
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spelling	oai:doaj.org-article:049d83c02bd448feb336fe01a336bc582021-12-02T16:58:13ZContext-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele10.1038/s41467-019-12393-12041-1723https://doaj.org/article/049d83c02bd448feb336fe01a336bc582019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12393-1https://doaj.org/toc/2041-1723Interleukin-7 (IL-7) is a central cytokine in T cell homeostasis. Here the authors show that allelic variation at rs6897932, an autoimmune GWAS risk allele at IL7R, regulates surface and soluble IL-7R in stimulated monocytes, indicating a function of monocytes in IL-7-related autoimmunity.Hussein Al-MossawiNicole YagerChelsea A. TaylorEvelyn LauSara DanielliJelle de WitJames GilchristIsar NassiriElise A. MaheWanseon LeeLaila RizviSeiko MakinoJane CheesemanMatt NevilleJulian C. KnightPaul BownessBenjamin P. FairfaxNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hussein Al-Mossawi Nicole Yager Chelsea A. Taylor Evelyn Lau Sara Danielli Jelle de Wit James Gilchrist Isar Nassiri Elise A. Mahe Wanseon Lee Laila Rizvi Seiko Makino Jane Cheeseman Matt Neville Julian C. Knight Paul Bowness Benjamin P. Fairfax Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele
description	Interleukin-7 (IL-7) is a central cytokine in T cell homeostasis. Here the authors show that allelic variation at rs6897932, an autoimmune GWAS risk allele at IL7R, regulates surface and soluble IL-7R in stimulated monocytes, indicating a function of monocytes in IL-7-related autoimmunity.
format	article
author	Hussein Al-Mossawi Nicole Yager Chelsea A. Taylor Evelyn Lau Sara Danielli Jelle de Wit James Gilchrist Isar Nassiri Elise A. Mahe Wanseon Lee Laila Rizvi Seiko Makino Jane Cheeseman Matt Neville Julian C. Knight Paul Bowness Benjamin P. Fairfax
author_facet	Hussein Al-Mossawi Nicole Yager Chelsea A. Taylor Evelyn Lau Sara Danielli Jelle de Wit James Gilchrist Isar Nassiri Elise A. Mahe Wanseon Lee Laila Rizvi Seiko Makino Jane Cheeseman Matt Neville Julian C. Knight Paul Bowness Benjamin P. Fairfax
author_sort	Hussein Al-Mossawi
title	Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele
title_short	Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele
title_full	Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele
title_fullStr	Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele
title_full_unstemmed	Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele
title_sort	context-specific regulation of surface and soluble il7r expression by an autoimmune risk allele
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/049d83c02bd448feb336fe01a336bc58
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Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele

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