Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele

Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele

Interleukin-7 (IL-7) is a central cytokine in T cell homeostasis. Here the authors show that allelic variation at rs6897932, an autoimmune GWAS risk allele at IL7R, regulates surface and soluble IL-7R in stimulated monocytes, indicating a function of monocytes in IL-7-related autoimmunity.

Saved in:
Bibliographic Details
Main Authors: Hussein Al-Mossawi, Nicole Yager, Chelsea A. Taylor, Evelyn Lau, Sara Danielli, Jelle de Wit, James Gilchrist, Isar Nassiri, Elise A. Mahe, Wanseon Lee, Laila Rizvi, Seiko Makino, Jane Cheeseman, Matt Neville, Julian C. Knight, Paul Bowness, Benjamin P. Fairfax
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Science
Q
Online Access:https://doaj.org/article/049d83c02bd448feb336fe01a336bc58
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/049d83c02bd448feb336fe01a336bc58

Similar Items