Particle size and cholesterol content of circulating HDL correlate with cardiovascular death in chronic heart failure
Abstract Evidence regarding any association of HDL-particle (HDL-P) derangements and HDL-cholesterol content with cardiovascular (CV) death in chronic heart failure (HF) is lacking. To investigate the prognostic value of HDL-P size (HDL-Sz) and the number of cholesterol molecules per HDL-P for CV de...
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Nature Portfolio
2021
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oai:doaj.org-article:049e46132c134af89d853f441e5e05c92021-12-02T14:06:57ZParticle size and cholesterol content of circulating HDL correlate with cardiovascular death in chronic heart failure10.1038/s41598-021-82861-62045-2322https://doaj.org/article/049e46132c134af89d853f441e5e05c92021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82861-6https://doaj.org/toc/2045-2322Abstract Evidence regarding any association of HDL-particle (HDL-P) derangements and HDL-cholesterol content with cardiovascular (CV) death in chronic heart failure (HF) is lacking. To investigate the prognostic value of HDL-P size (HDL-Sz) and the number of cholesterol molecules per HDL-P for CV death in HF patients. Outpatient chronic HF patients were enrolled. Baseline HDL-P number, subfractions and HDL-Sz were measured using 1H-NMR spectroscopy. The HDL-C/P ratio was calculated as HDL-cholesterol over HDL-P. Endpoint was CV death, with non-CV death as the competing event. 422 patients were included and followed-up during a median of 4.1 (0–8) years. CV death occurred in 120 (30.5%) patients. Mean HDL-Sz was higher in CV dead as compared with survivors (8.39 nm vs. 8.31 nm, p < 0.001). This change in size was due to a reduction in the percentage of small HDL-P (54.6% vs. 60% for CV-death vs. alive; p < 0.001). HDL-C/P ratio was higher in the CV-death group (51.0 vs. 48.3, p < 0.001). HDL-Sz and HDL-C/P ratio were significantly associated with CV death after multivariable regression analysis (HR 1.22 [95% CI 1.01–1.47], p = 0.041 and HR 1.04 [95% CI 1.01–1.07], p = 0.008 respectively). HDL-Sz and HDL-C/P ratio are independent predictors of CV death in chronic HF patients.Albert TeisG. CedielN. AmigóJ. JulveJ. AranyóJ. Andrés-CordónC. Puig-JovéE. CastelblancoF. Gual-CapllonchE. Ferrer-SistachN. VallejoG. JuncàJ. López-AyerbeM. De AntonioM. DomingoE. Santiago-VacasP. CodinaD. MauricioJ. LupónNuria AlonsoA. Bayes-GenisNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
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DOAJ |
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EN |
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Medicine R Science Q |
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Medicine R Science Q Albert Teis G. Cediel N. Amigó J. Julve J. Aranyó J. Andrés-Cordón C. Puig-Jové E. Castelblanco F. Gual-Capllonch E. Ferrer-Sistach N. Vallejo G. Juncà J. López-Ayerbe M. De Antonio M. Domingo E. Santiago-Vacas P. Codina D. Mauricio J. Lupón Nuria Alonso A. Bayes-Genis Particle size and cholesterol content of circulating HDL correlate with cardiovascular death in chronic heart failure |
| description |
Abstract Evidence regarding any association of HDL-particle (HDL-P) derangements and HDL-cholesterol content with cardiovascular (CV) death in chronic heart failure (HF) is lacking. To investigate the prognostic value of HDL-P size (HDL-Sz) and the number of cholesterol molecules per HDL-P for CV death in HF patients. Outpatient chronic HF patients were enrolled. Baseline HDL-P number, subfractions and HDL-Sz were measured using 1H-NMR spectroscopy. The HDL-C/P ratio was calculated as HDL-cholesterol over HDL-P. Endpoint was CV death, with non-CV death as the competing event. 422 patients were included and followed-up during a median of 4.1 (0–8) years. CV death occurred in 120 (30.5%) patients. Mean HDL-Sz was higher in CV dead as compared with survivors (8.39 nm vs. 8.31 nm, p < 0.001). This change in size was due to a reduction in the percentage of small HDL-P (54.6% vs. 60% for CV-death vs. alive; p < 0.001). HDL-C/P ratio was higher in the CV-death group (51.0 vs. 48.3, p < 0.001). HDL-Sz and HDL-C/P ratio were significantly associated with CV death after multivariable regression analysis (HR 1.22 [95% CI 1.01–1.47], p = 0.041 and HR 1.04 [95% CI 1.01–1.07], p = 0.008 respectively). HDL-Sz and HDL-C/P ratio are independent predictors of CV death in chronic HF patients. |
| format |
article |
| author |
Albert Teis G. Cediel N. Amigó J. Julve J. Aranyó J. Andrés-Cordón C. Puig-Jové E. Castelblanco F. Gual-Capllonch E. Ferrer-Sistach N. Vallejo G. Juncà J. López-Ayerbe M. De Antonio M. Domingo E. Santiago-Vacas P. Codina D. Mauricio J. Lupón Nuria Alonso A. Bayes-Genis |
| author_facet |
Albert Teis G. Cediel N. Amigó J. Julve J. Aranyó J. Andrés-Cordón C. Puig-Jové E. Castelblanco F. Gual-Capllonch E. Ferrer-Sistach N. Vallejo G. Juncà J. López-Ayerbe M. De Antonio M. Domingo E. Santiago-Vacas P. Codina D. Mauricio J. Lupón Nuria Alonso A. Bayes-Genis |
| author_sort |
Albert Teis |
| title |
Particle size and cholesterol content of circulating HDL correlate with cardiovascular death in chronic heart failure |
| title_short |
Particle size and cholesterol content of circulating HDL correlate with cardiovascular death in chronic heart failure |
| title_full |
Particle size and cholesterol content of circulating HDL correlate with cardiovascular death in chronic heart failure |
| title_fullStr |
Particle size and cholesterol content of circulating HDL correlate with cardiovascular death in chronic heart failure |
| title_full_unstemmed |
Particle size and cholesterol content of circulating HDL correlate with cardiovascular death in chronic heart failure |
| title_sort |
particle size and cholesterol content of circulating hdl correlate with cardiovascular death in chronic heart failure |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/049e46132c134af89d853f441e5e05c9 |
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