[38] Efficacy of silodosin on the outcome of semi-rigid ureteroscopy for management of large distal ureteric calculi: single-blinded placebo-controlled randomised trial

Objective: To evaluate the efficacy of administration of silodosin, as a new α-adrenergic blocker (AAB), on the success rate of semi-rigid ureteroscopy (URS) for the management of large distal ureteric stones. Methods: This prospective study recruited 127 adult patients with single distal ureteric s...

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Autores principales:	Yasser Noureldin, Ahmed Mohey, Tarek Gharib, Hisham Alazaby, Mostafa Khalil, Ahmed Abou-Taleb
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2018
Materias:	Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/04a09a6c7218466c96bfaa43e7193ec7
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spelling	oai:doaj.org-article:04a09a6c7218466c96bfaa43e7193ec72021-12-02T10:11:40Z[38] Efficacy of silodosin on the outcome of semi-rigid ureteroscopy for management of large distal ureteric calculi: single-blinded placebo-controlled randomised trial2090-598X10.1016/j.aju.2018.10.085https://doaj.org/article/04a09a6c7218466c96bfaa43e7193ec72018-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2090598X18301797https://doaj.org/toc/2090-598XObjective: To evaluate the efficacy of administration of silodosin, as a new α-adrenergic blocker (AAB), on the success rate of semi-rigid ureteroscopy (URS) for the management of large distal ureteric stones. Methods: This prospective study recruited 127 adult patients with single distal ureteric stones of ⩾1 cm. Patients were randomly allocated to two groups. The first group included 62 patients who received silodosin (8 mg) for 10 days before URS (Silodosin Group), whilst the second group included 65 patients who received placebo in the form of multivitamins for 10 days before URS (Placebo Group). All patients underwent URS and a pneumatic lithoclast was used. Results: The mean operative time was shorter in the Silodosin Group than in the Placebo Group, at a mean (SD) of 41.61 (4.67) vs 46.85 (4.6) min, respectively. Furthermore, forwarding the ureteroscope to access the stone failed in a statistically significant number of patients in the Placebo Group compared with the Silodosin Group (13 vs two cases, respectively). The complication rate was significantly higher in the Placebo Group compared with the Silodosin Group (20% vs 6.4%, P = 0.036). Moreover, the need for postoperative analgesia was significantly lower in the Silodosin Group compared with the Placebo Group (8.1% vs 26.2%, P = 0.009). Conclusion: Silodosin intake before ureteroscopic management of large distal ureteric stones seems to be associated with better ureteroscope forwarding to access the stones, shorter procedural time, higher stone-free rate, lower incidence of complications, and lower need for postoperative analgesia.Yasser NoureldinAhmed MoheyTarek GharibHisham AlazabyMostafa KhalilAhmed Abou-TalebTaylor & Francis GrouparticleDiseases of the genitourinary system. UrologyRC870-923ENArab Journal of Urology, Vol 16, Iss , Pp S19- (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Diseases of the genitourinary system. Urology RC870-923 Yasser Noureldin Ahmed Mohey Tarek Gharib Hisham Alazaby Mostafa Khalil Ahmed Abou-Taleb [38] Efficacy of silodosin on the outcome of semi-rigid ureteroscopy for management of large distal ureteric calculi: single-blinded placebo-controlled randomised trial
description	Objective: To evaluate the efficacy of administration of silodosin, as a new α-adrenergic blocker (AAB), on the success rate of semi-rigid ureteroscopy (URS) for the management of large distal ureteric stones. Methods: This prospective study recruited 127 adult patients with single distal ureteric stones of ⩾1 cm. Patients were randomly allocated to two groups. The first group included 62 patients who received silodosin (8 mg) for 10 days before URS (Silodosin Group), whilst the second group included 65 patients who received placebo in the form of multivitamins for 10 days before URS (Placebo Group). All patients underwent URS and a pneumatic lithoclast was used. Results: The mean operative time was shorter in the Silodosin Group than in the Placebo Group, at a mean (SD) of 41.61 (4.67) vs 46.85 (4.6) min, respectively. Furthermore, forwarding the ureteroscope to access the stone failed in a statistically significant number of patients in the Placebo Group compared with the Silodosin Group (13 vs two cases, respectively). The complication rate was significantly higher in the Placebo Group compared with the Silodosin Group (20% vs 6.4%, P = 0.036). Moreover, the need for postoperative analgesia was significantly lower in the Silodosin Group compared with the Placebo Group (8.1% vs 26.2%, P = 0.009). Conclusion: Silodosin intake before ureteroscopic management of large distal ureteric stones seems to be associated with better ureteroscope forwarding to access the stones, shorter procedural time, higher stone-free rate, lower incidence of complications, and lower need for postoperative analgesia.
format	article
author	Yasser Noureldin Ahmed Mohey Tarek Gharib Hisham Alazaby Mostafa Khalil Ahmed Abou-Taleb
author_facet	Yasser Noureldin Ahmed Mohey Tarek Gharib Hisham Alazaby Mostafa Khalil Ahmed Abou-Taleb
author_sort	Yasser Noureldin
title	[38] Efficacy of silodosin on the outcome of semi-rigid ureteroscopy for management of large distal ureteric calculi: single-blinded placebo-controlled randomised trial
title_short	[38] Efficacy of silodosin on the outcome of semi-rigid ureteroscopy for management of large distal ureteric calculi: single-blinded placebo-controlled randomised trial
title_full	[38] Efficacy of silodosin on the outcome of semi-rigid ureteroscopy for management of large distal ureteric calculi: single-blinded placebo-controlled randomised trial
title_fullStr	[38] Efficacy of silodosin on the outcome of semi-rigid ureteroscopy for management of large distal ureteric calculi: single-blinded placebo-controlled randomised trial
title_full_unstemmed	[38] Efficacy of silodosin on the outcome of semi-rigid ureteroscopy for management of large distal ureteric calculi: single-blinded placebo-controlled randomised trial
title_sort	[38] efficacy of silodosin on the outcome of semi-rigid ureteroscopy for management of large distal ureteric calculi: single-blinded placebo-controlled randomised trial
publisher	Taylor & Francis Group
publishDate	2018
url	https://doaj.org/article/04a09a6c7218466c96bfaa43e7193ec7
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[38] Efficacy of silodosin on the outcome of semi-rigid ureteroscopy for management of large distal ureteric calculi: single-blinded placebo-controlled randomised trial

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