Parathyroid function and calcium concentration in serum of dexamethasone treated rabbits

This experiment was carried out to determine structural functional changes which could be caused due to uses of dexamethasone at daily therapeutic doses in rabbits for a reasonable period. Ten adult male rabbits were randomly divided into two equal groups control and treatment. Animals of the treat...

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Autores principales:	Mashi S. K., Al-Ar'rak J. K.
Formato:	article
Lenguaje:	EN
Publicado:	University of Baghdad, College of Veterinary Medicine 2000
Materias:	rabbits Parathyroid calcium dexamethasone Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/04a5ea3eb17e4dceba095481e3de9fcd
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spelling	oai:doaj.org-article:04a5ea3eb17e4dceba095481e3de9fcd2021-11-09T11:36:40ZParathyroid function and calcium concentration in serum of dexamethasone treated rabbits10.30539/ijvm.v24i2.11711609-56932410-7409https://doaj.org/article/04a5ea3eb17e4dceba095481e3de9fcd2000-12-01T00:00:00Zhttps://jcovm.uobaghdad.edu.iq/index.php/Iraqijvm/article/view/1171https://doaj.org/toc/1609-5693https://doaj.org/toc/2410-7409 This experiment was carried out to determine structural functional changes which could be caused due to uses of dexamethasone at daily therapeutic doses in rabbits for a reasonable period. Ten adult male rabbits were randomly divided into two equal groups control and treatment. Animals of the treatment group were intramuscularly injected with dexamethasone sod. citrate (0.06 mg/100g.B.W.) for 14 days. Animals of control group received the same dose of normal physiological saline solution blood samples were collected every other day until 48 hours after the last injection serum was isolated for measurement of calcium concentrations. At the end of the experiment tissue samples from the parathyroid glands were isolate to prepare histological stained sections . Dexamethasone did not cause significant changes in serum concentration of calcium of treated group compared with its concentrations in control group. Light microscopic examination of hematoxylin eosion stained sections of parathyroid gland showed enlargement and increase in number of light chief cells indicating increased secretory activity due to dexamethasone injection. The increased of parathyroid gland activity explain the maintenance of total calcium level within the normal range in spite of the expected hypocalcemia due to dexamethasone administration. Mashi S. K.Al-Ar'rak J. K.University of Baghdad, College of Veterinary MedicinearticlerabbitsParathyroidcalciumdexamethasoneVeterinary medicineSF600-1100ENThe Iraqi Journal of Veterinary Medicine, Vol 24, Iss 2 (2000)
institution	DOAJ
collection	DOAJ
language	EN
topic	rabbits Parathyroid calcium dexamethasone Veterinary medicine SF600-1100
spellingShingle	rabbits Parathyroid calcium dexamethasone Veterinary medicine SF600-1100 Mashi S. K. Al-Ar'rak J. K. Parathyroid function and calcium concentration in serum of dexamethasone treated rabbits
description	This experiment was carried out to determine structural functional changes which could be caused due to uses of dexamethasone at daily therapeutic doses in rabbits for a reasonable period. Ten adult male rabbits were randomly divided into two equal groups control and treatment. Animals of the treatment group were intramuscularly injected with dexamethasone sod. citrate (0.06 mg/100g.B.W.) for 14 days. Animals of control group received the same dose of normal physiological saline solution blood samples were collected every other day until 48 hours after the last injection serum was isolated for measurement of calcium concentrations. At the end of the experiment tissue samples from the parathyroid glands were isolate to prepare histological stained sections . Dexamethasone did not cause significant changes in serum concentration of calcium of treated group compared with its concentrations in control group. Light microscopic examination of hematoxylin eosion stained sections of parathyroid gland showed enlargement and increase in number of light chief cells indicating increased secretory activity due to dexamethasone injection. The increased of parathyroid gland activity explain the maintenance of total calcium level within the normal range in spite of the expected hypocalcemia due to dexamethasone administration.
format	article
author	Mashi S. K. Al-Ar'rak J. K.
author_facet	Mashi S. K. Al-Ar'rak J. K.
author_sort	Mashi S. K.
title	Parathyroid function and calcium concentration in serum of dexamethasone treated rabbits
title_short	Parathyroid function and calcium concentration in serum of dexamethasone treated rabbits
title_full	Parathyroid function and calcium concentration in serum of dexamethasone treated rabbits
title_fullStr	Parathyroid function and calcium concentration in serum of dexamethasone treated rabbits
title_full_unstemmed	Parathyroid function and calcium concentration in serum of dexamethasone treated rabbits
title_sort	parathyroid function and calcium concentration in serum of dexamethasone treated rabbits
publisher	University of Baghdad, College of Veterinary Medicine
publishDate	2000
url	https://doaj.org/article/04a5ea3eb17e4dceba095481e3de9fcd
work_keys_str_mv	AT mashisk parathyroidfunctionandcalciumconcentrationinserumofdexamethasonetreatedrabbits AT alarrakjk parathyroidfunctionandcalciumconcentrationinserumofdexamethasonetreatedrabbits
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Parathyroid function and calcium concentration in serum of dexamethasone treated rabbits

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