Optimized Synthesis of New Thiosemicarbazide Derivatives with Tuberculostatic Activity

Original results are presented in the field of research that addresses the extension of the reaction of residue of acyl-thiosemicarbazide fixation on the structure of 5-nitrobenzimidazole by a sulphonic group. The aim of the study is the increase of new thiosemicarbazide derivatives’ applicative pot...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Corina Popovici, Cristina-Maria Pavel, Valeriu Sunel, Corina Cheptea, Dan Gheorghe Dimitriu, Dana Ortansa Dorohoi, Diana David, Valentina Closca, Marcel Popa
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	2-mercapto-benzimidazole sulfonic derivatives heterocyclic thiosemicarbazides tuberculostatic activity Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/04a6f0ce30ec47b2b9bb10283d1c308c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:04a6f0ce30ec47b2b9bb10283d1c308c
record_format	dspace
spelling	oai:doaj.org-article:04a6f0ce30ec47b2b9bb10283d1c308c2021-11-25T17:53:44ZOptimized Synthesis of New Thiosemicarbazide Derivatives with Tuberculostatic Activity10.3390/ijms2222121391422-00671661-6596https://doaj.org/article/04a6f0ce30ec47b2b9bb10283d1c308c2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12139https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Original results are presented in the field of research that addresses the extension of the reaction of residue of acyl-thiosemicarbazide fixation on the structure of 5-nitrobenzimidazole by a sulphonic group. The aim of the study is the increase of new thiosemicarbazide derivatives’ applicative potential in the field of biochemistry, with a wide range of medical applications. The newly obtained compounds were characterized by using elemental analysis and spectral analysis (FT-IR and <sup>1</sup>H NMR). A study regarding the optimization of the chemical reactions was made. The performed in vitro biological tests confirmed the tuberculostatic activity of three newly obtained compounds against <i>Mycobacterium tuberculosis</i>.Corina PopoviciCristina-Maria PavelValeriu SunelCorina ChepteaDan Gheorghe DimitriuDana Ortansa DorohoiDiana DavidValentina CloscaMarcel PopaMDPI AGarticle2-mercapto-benzimidazolesulfonic derivativesheterocyclic thiosemicarbazidestuberculostatic activityBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12139, p 12139 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	2-mercapto-benzimidazole sulfonic derivatives heterocyclic thiosemicarbazides tuberculostatic activity Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	2-mercapto-benzimidazole sulfonic derivatives heterocyclic thiosemicarbazides tuberculostatic activity Biology (General) QH301-705.5 Chemistry QD1-999 Corina Popovici Cristina-Maria Pavel Valeriu Sunel Corina Cheptea Dan Gheorghe Dimitriu Dana Ortansa Dorohoi Diana David Valentina Closca Marcel Popa Optimized Synthesis of New Thiosemicarbazide Derivatives with Tuberculostatic Activity
description	Original results are presented in the field of research that addresses the extension of the reaction of residue of acyl-thiosemicarbazide fixation on the structure of 5-nitrobenzimidazole by a sulphonic group. The aim of the study is the increase of new thiosemicarbazide derivatives’ applicative potential in the field of biochemistry, with a wide range of medical applications. The newly obtained compounds were characterized by using elemental analysis and spectral analysis (FT-IR and <sup>1</sup>H NMR). A study regarding the optimization of the chemical reactions was made. The performed in vitro biological tests confirmed the tuberculostatic activity of three newly obtained compounds against <i>Mycobacterium tuberculosis</i>.
format	article
author	Corina Popovici Cristina-Maria Pavel Valeriu Sunel Corina Cheptea Dan Gheorghe Dimitriu Dana Ortansa Dorohoi Diana David Valentina Closca Marcel Popa
author_facet	Corina Popovici Cristina-Maria Pavel Valeriu Sunel Corina Cheptea Dan Gheorghe Dimitriu Dana Ortansa Dorohoi Diana David Valentina Closca Marcel Popa
author_sort	Corina Popovici
title	Optimized Synthesis of New Thiosemicarbazide Derivatives with Tuberculostatic Activity
title_short	Optimized Synthesis of New Thiosemicarbazide Derivatives with Tuberculostatic Activity
title_full	Optimized Synthesis of New Thiosemicarbazide Derivatives with Tuberculostatic Activity
title_fullStr	Optimized Synthesis of New Thiosemicarbazide Derivatives with Tuberculostatic Activity
title_full_unstemmed	Optimized Synthesis of New Thiosemicarbazide Derivatives with Tuberculostatic Activity
title_sort	optimized synthesis of new thiosemicarbazide derivatives with tuberculostatic activity
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/04a6f0ce30ec47b2b9bb10283d1c308c
work_keys_str_mv	AT corinapopovici optimizedsynthesisofnewthiosemicarbazidederivativeswithtuberculostaticactivity AT cristinamariapavel optimizedsynthesisofnewthiosemicarbazidederivativeswithtuberculostaticactivity AT valeriusunel optimizedsynthesisofnewthiosemicarbazidederivativeswithtuberculostaticactivity AT corinacheptea optimizedsynthesisofnewthiosemicarbazidederivativeswithtuberculostaticactivity AT dangheorghedimitriu optimizedsynthesisofnewthiosemicarbazidederivativeswithtuberculostaticactivity AT danaortansadorohoi optimizedsynthesisofnewthiosemicarbazidederivativeswithtuberculostaticactivity AT dianadavid optimizedsynthesisofnewthiosemicarbazidederivativeswithtuberculostaticactivity AT valentinaclosca optimizedsynthesisofnewthiosemicarbazidederivativeswithtuberculostaticactivity AT marcelpopa optimizedsynthesisofnewthiosemicarbazidederivativeswithtuberculostaticactivity
_version_	1718411841970896896

Optimized Synthesis of New Thiosemicarbazide Derivatives with Tuberculostatic Activity

Ejemplares similares