Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution

Methods that analyze intra-tumor genetic heterogeneity often do not preserve the spatial context of tumor subclones. Here, the authors present BaseScope, a mutation-specific RNA in situ hybridization assay and spatially map colorectal cancer and adenoma KRAS, BRAF and PIK3CA driver gene mutant subcl...

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Autores principales:	Ann-Marie Baker, Weini Huang, Xiao-Ming Mindy Wang, Marnix Jansen, Xiao-Jun Ma, Jeffrey Kim, Courtney M. Anderson, Xingyong Wu, Liuliu Pan, Nan Su, Yuling Luo, Enric Domingo, Timon Heide, Andrea Sottoriva, Annabelle Lewis, Andrew D. Beggs, Nicholas A. Wright, Manuel Rodriguez-Justo, Emily Park, Ian Tomlinson, Trevor A. Graham
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/04a8b784261d4d7da0ef04bead32687f
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spelling	oai:doaj.org-article:04a8b784261d4d7da0ef04bead32687f2021-12-02T17:01:16ZRobust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution10.1038/s41467-017-02295-52041-1723https://doaj.org/article/04a8b784261d4d7da0ef04bead32687f2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02295-5https://doaj.org/toc/2041-1723Methods that analyze intra-tumor genetic heterogeneity often do not preserve the spatial context of tumor subclones. Here, the authors present BaseScope, a mutation-specific RNA in situ hybridization assay and spatially map colorectal cancer and adenoma KRAS, BRAF and PIK3CA driver gene mutant subclones.Ann-Marie BakerWeini HuangXiao-Ming Mindy WangMarnix JansenXiao-Jun MaJeffrey KimCourtney M. AndersonXingyong WuLiuliu PanNan SuYuling LuoEnric DomingoTimon HeideAndrea SottorivaAnnabelle LewisAndrew D. BeggsNicholas A. WrightManuel Rodriguez-JustoEmily ParkIan TomlinsonTrevor A. GrahamNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ann-Marie Baker Weini Huang Xiao-Ming Mindy Wang Marnix Jansen Xiao-Jun Ma Jeffrey Kim Courtney M. Anderson Xingyong Wu Liuliu Pan Nan Su Yuling Luo Enric Domingo Timon Heide Andrea Sottoriva Annabelle Lewis Andrew D. Beggs Nicholas A. Wright Manuel Rodriguez-Justo Emily Park Ian Tomlinson Trevor A. Graham Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution
description	Methods that analyze intra-tumor genetic heterogeneity often do not preserve the spatial context of tumor subclones. Here, the authors present BaseScope, a mutation-specific RNA in situ hybridization assay and spatially map colorectal cancer and adenoma KRAS, BRAF and PIK3CA driver gene mutant subclones.
format	article
author	Ann-Marie Baker Weini Huang Xiao-Ming Mindy Wang Marnix Jansen Xiao-Jun Ma Jeffrey Kim Courtney M. Anderson Xingyong Wu Liuliu Pan Nan Su Yuling Luo Enric Domingo Timon Heide Andrea Sottoriva Annabelle Lewis Andrew D. Beggs Nicholas A. Wright Manuel Rodriguez-Justo Emily Park Ian Tomlinson Trevor A. Graham
author_facet	Ann-Marie Baker Weini Huang Xiao-Ming Mindy Wang Marnix Jansen Xiao-Jun Ma Jeffrey Kim Courtney M. Anderson Xingyong Wu Liuliu Pan Nan Su Yuling Luo Enric Domingo Timon Heide Andrea Sottoriva Annabelle Lewis Andrew D. Beggs Nicholas A. Wright Manuel Rodriguez-Justo Emily Park Ian Tomlinson Trevor A. Graham
author_sort	Ann-Marie Baker
title	Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution
title_short	Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution
title_full	Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution
title_fullStr	Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution
title_full_unstemmed	Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution
title_sort	robust rna-based in situ mutation detection delineates colorectal cancer subclonal evolution
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/04a8b784261d4d7da0ef04bead32687f
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Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution

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