AtrR Is an Essential Determinant of Azole Resistance in <named-content content-type="genus-species">Aspergillus fumigatus</named-content>

AtrR Is an Essential Determinant of Azole Resistance in <named-content content-type="genus-species">Aspergillus fumigatus</named-content>

ABSTRACT Aspergillosis associated with azole-resistant Aspergillus fumigatus has a mortality rate that can approach 90% in certain patient populations. The best-understood avenue for azole resistance involves changes in the cyp51A gene that encodes the target of azole drugs, lanosterol α-14 demethyl...

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Autores principales: Sanjoy Paul, Mark Stamnes, Grace Heredge Thomas, Hong Liu, Daisuke Hagiwara, Katsuya Gomi, Scott G. Filler, W. Scott Moye-Rowley
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2019
Materias:
ABC transporters
antifungal resistance
Aspergillus fumigatus
molecular genetics
transcriptional regulation
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/04ab0a88ea04405a8699079ec5d9d53e
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