Application of multifunctional targeting epirubicin liposomes in the treatment of non-small-cell lung cancer

Xiao-li Song,1 Rui-jun Ju,2 Yao Xiao,1 Xin Wang,1 Shuang Liu,1 Min Fu,1 Jing-jing Liu,1 Li-yan Gu,1 Xue-tao Li,1 Lan Cheng1 1School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, 2Department of Pharmaceutical Engineering, Beijing Institute of Petrochemical Technology, Bei...

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Autores principales:	Song X, Ju R, Xiao Y, Wang X, Liu S, Fu M, Liu J, Gu L, Li X, Cheng L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	octreotide honokiol epirubicin vasculogenic mimicry tumor metastasis non-small cell lung cancer Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/04ad35214d4e45efb3e8879005f57642
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spelling	oai:doaj.org-article:04ad35214d4e45efb3e8879005f576422021-12-02T07:13:45ZApplication of multifunctional targeting epirubicin liposomes in the treatment of non-small-cell lung cancer1178-2013https://doaj.org/article/04ad35214d4e45efb3e8879005f576422017-10-01T00:00:00Zhttps://www.dovepress.com/application-of-multifunctional-targeting-epirubicin-liposomes-in-the-t-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Xiao-li Song,1 Rui-jun Ju,2 Yao Xiao,1 Xin Wang,1 Shuang Liu,1 Min Fu,1 Jing-jing Liu,1 Li-yan Gu,1 Xue-tao Li,1 Lan Cheng1 1School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, 2Department of Pharmaceutical Engineering, Beijing Institute of Petrochemical Technology, Beijing, China Abstract: Chemotherapy for aggressive non-small-cell lung cancer (NSCLC) usually results in a poor prognosis due to tumor metastasis, vasculogenic mimicry (VM) channels, limited killing of tumor cells, and severe systemic toxicity. Herein, we developed a kind of multifunctional targeting epirubicin liposomes to enhance antitumor efficacy for NSCLC. In the liposomes, octreotide was modified on liposomal surface for obtaining a receptor-mediated targeting effect, and honokiol was incorporated into the lipid bilayer for inhibiting tumor metastasis and eliminating VM channels. In vitro cellular assays showed that multifunctional targeting epirubicin liposomes not only exhibited the strongest cytotoxic effect on Lewis lung tumor cells but also showed the most efficient inhibition on VM channels. Action mechanism studies showed that multifunctional targeting epirubicin liposomes could downregulate PI3K, MMP-2, MMP-9, VE-Cadherin, and FAK and activate apoptotic enzyme caspase 3. In vivo results exhibited that multifunctional targeting epirubicin liposomes could accumulate selectively in tumor site and display an obvious antitumor efficacy. In addition, no significant toxicity of blood system and major organs was observed at a test dose. Therefore, multifunctional targeting epirubicin liposomes may provide a safe and efficient therapy strategy for NSCLC. Keywords: octreotide, honokiol, chemotherapy, vasculogenic mimicry, tumor metastasis, targeting drug deliverySong XJu RXiao YWang XLiu SFu MLiu JGu LLi XCheng LDove Medical Pressarticleoctreotidehonokiolepirubicinvasculogenic mimicrytumor metastasisnon-small cell lung cancerMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 7433-7451 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	octreotide honokiol epirubicin vasculogenic mimicry tumor metastasis non-small cell lung cancer Medicine (General) R5-920
spellingShingle	octreotide honokiol epirubicin vasculogenic mimicry tumor metastasis non-small cell lung cancer Medicine (General) R5-920 Song X Ju R Xiao Y Wang X Liu S Fu M Liu J Gu L Li X Cheng L Application of multifunctional targeting epirubicin liposomes in the treatment of non-small-cell lung cancer
description	Xiao-li Song,1 Rui-jun Ju,2 Yao Xiao,1 Xin Wang,1 Shuang Liu,1 Min Fu,1 Jing-jing Liu,1 Li-yan Gu,1 Xue-tao Li,1 Lan Cheng1 1School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, 2Department of Pharmaceutical Engineering, Beijing Institute of Petrochemical Technology, Beijing, China Abstract: Chemotherapy for aggressive non-small-cell lung cancer (NSCLC) usually results in a poor prognosis due to tumor metastasis, vasculogenic mimicry (VM) channels, limited killing of tumor cells, and severe systemic toxicity. Herein, we developed a kind of multifunctional targeting epirubicin liposomes to enhance antitumor efficacy for NSCLC. In the liposomes, octreotide was modified on liposomal surface for obtaining a receptor-mediated targeting effect, and honokiol was incorporated into the lipid bilayer for inhibiting tumor metastasis and eliminating VM channels. In vitro cellular assays showed that multifunctional targeting epirubicin liposomes not only exhibited the strongest cytotoxic effect on Lewis lung tumor cells but also showed the most efficient inhibition on VM channels. Action mechanism studies showed that multifunctional targeting epirubicin liposomes could downregulate PI3K, MMP-2, MMP-9, VE-Cadherin, and FAK and activate apoptotic enzyme caspase 3. In vivo results exhibited that multifunctional targeting epirubicin liposomes could accumulate selectively in tumor site and display an obvious antitumor efficacy. In addition, no significant toxicity of blood system and major organs was observed at a test dose. Therefore, multifunctional targeting epirubicin liposomes may provide a safe and efficient therapy strategy for NSCLC. Keywords: octreotide, honokiol, chemotherapy, vasculogenic mimicry, tumor metastasis, targeting drug delivery
format	article
author	Song X Ju R Xiao Y Wang X Liu S Fu M Liu J Gu L Li X Cheng L
author_facet	Song X Ju R Xiao Y Wang X Liu S Fu M Liu J Gu L Li X Cheng L
author_sort	Song X
title	Application of multifunctional targeting epirubicin liposomes in the treatment of non-small-cell lung cancer
title_short	Application of multifunctional targeting epirubicin liposomes in the treatment of non-small-cell lung cancer
title_full	Application of multifunctional targeting epirubicin liposomes in the treatment of non-small-cell lung cancer
title_fullStr	Application of multifunctional targeting epirubicin liposomes in the treatment of non-small-cell lung cancer
title_full_unstemmed	Application of multifunctional targeting epirubicin liposomes in the treatment of non-small-cell lung cancer
title_sort	application of multifunctional targeting epirubicin liposomes in the treatment of non-small-cell lung cancer
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/04ad35214d4e45efb3e8879005f57642
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Application of multifunctional targeting epirubicin liposomes in the treatment of non-small-cell lung cancer

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