A brain-machine-muscle interface for restoring hindlimb locomotion after complete spinal transection in rats.

A brain-machine interface (BMI) is a neuroprosthetic device that can restore motor function of individuals with paralysis. Although the feasibility of BMI control of upper-limb neuroprostheses has been demonstrated, a BMI for the restoration of lower-limb motor functions has not yet been developed....

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Autores principales:	Monzurul Alam, Xi Chen, Zicong Zhang, Yan Li, Jufang He
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/04b1b5414d0044fbad5e87274d47b148
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spelling	oai:doaj.org-article:04b1b5414d0044fbad5e87274d47b1482021-11-25T06:06:17ZA brain-machine-muscle interface for restoring hindlimb locomotion after complete spinal transection in rats.1932-620310.1371/journal.pone.0103764https://doaj.org/article/04b1b5414d0044fbad5e87274d47b1482014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25084446/?tool=EBIhttps://doaj.org/toc/1932-6203A brain-machine interface (BMI) is a neuroprosthetic device that can restore motor function of individuals with paralysis. Although the feasibility of BMI control of upper-limb neuroprostheses has been demonstrated, a BMI for the restoration of lower-limb motor functions has not yet been developed. The objective of this study was to determine if gait-related information can be captured from neural activity recorded from the primary motor cortex of rats, and if this neural information can be used to stimulate paralysed hindlimb muscles after complete spinal cord transection. Neural activity was recorded from the hindlimb area of the primary motor cortex of six female Sprague Dawley rats during treadmill locomotion before and after mid-thoracic transection. Before spinal transection there was a strong association between neural activity and the step cycle. This association decreased after spinal transection. However, the locomotive state (standing vs. walking) could still be successfully decoded from neural recordings made after spinal transection. A novel BMI device was developed that processed this neural information in real-time and used it to control electrical stimulation of paralysed hindlimb muscles. This system was able to elicit hindlimb muscle contractions that mimicked forelimb stepping. We propose this lower-limb BMI as a future neuroprosthesis for human paraplegics.Monzurul AlamXi ChenZicong ZhangYan LiJufang HePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e103764 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Monzurul Alam Xi Chen Zicong Zhang Yan Li Jufang He A brain-machine-muscle interface for restoring hindlimb locomotion after complete spinal transection in rats.
description	A brain-machine interface (BMI) is a neuroprosthetic device that can restore motor function of individuals with paralysis. Although the feasibility of BMI control of upper-limb neuroprostheses has been demonstrated, a BMI for the restoration of lower-limb motor functions has not yet been developed. The objective of this study was to determine if gait-related information can be captured from neural activity recorded from the primary motor cortex of rats, and if this neural information can be used to stimulate paralysed hindlimb muscles after complete spinal cord transection. Neural activity was recorded from the hindlimb area of the primary motor cortex of six female Sprague Dawley rats during treadmill locomotion before and after mid-thoracic transection. Before spinal transection there was a strong association between neural activity and the step cycle. This association decreased after spinal transection. However, the locomotive state (standing vs. walking) could still be successfully decoded from neural recordings made after spinal transection. A novel BMI device was developed that processed this neural information in real-time and used it to control electrical stimulation of paralysed hindlimb muscles. This system was able to elicit hindlimb muscle contractions that mimicked forelimb stepping. We propose this lower-limb BMI as a future neuroprosthesis for human paraplegics.
format	article
author	Monzurul Alam Xi Chen Zicong Zhang Yan Li Jufang He
author_facet	Monzurul Alam Xi Chen Zicong Zhang Yan Li Jufang He
author_sort	Monzurul Alam
title	A brain-machine-muscle interface for restoring hindlimb locomotion after complete spinal transection in rats.
title_short	A brain-machine-muscle interface for restoring hindlimb locomotion after complete spinal transection in rats.
title_full	A brain-machine-muscle interface for restoring hindlimb locomotion after complete spinal transection in rats.
title_fullStr	A brain-machine-muscle interface for restoring hindlimb locomotion after complete spinal transection in rats.
title_full_unstemmed	A brain-machine-muscle interface for restoring hindlimb locomotion after complete spinal transection in rats.
title_sort	brain-machine-muscle interface for restoring hindlimb locomotion after complete spinal transection in rats.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/04b1b5414d0044fbad5e87274d47b148
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A brain-machine-muscle interface for restoring hindlimb locomotion after complete spinal transection in rats.

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