A missense variant in SLC39A8 is associated with severe idiopathic scoliosis
The majority of scoliosis is considered idiopathic with onset in adolescence (AIS) and has a genetic contribution. Here, the authors perform an exome wide association study of data from 457 severe AIS cases and 987 controls, and find a missense variant in SLC39A8 is associated with AIS.
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Nature Portfolio
2018
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oai:doaj.org-article:04b3d3a563384542b1a9a97bf011c0d42021-12-02T15:33:36ZA missense variant in SLC39A8 is associated with severe idiopathic scoliosis10.1038/s41467-018-06705-02041-1723https://doaj.org/article/04b3d3a563384542b1a9a97bf011c0d42018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06705-0https://doaj.org/toc/2041-1723The majority of scoliosis is considered idiopathic with onset in adolescence (AIS) and has a genetic contribution. Here, the authors perform an exome wide association study of data from 457 severe AIS cases and 987 controls, and find a missense variant in SLC39A8 is associated with AIS.Gabe HallerKevin McCallSupak JenkitkasemwongBrooke SadlerLilian AntunesMomchil NikolovJulia WhittleZachary UpshawJimann ShinErin BaschalCarlos CruchagaMatthew HarmsCathleen RaggioJose A. MorcuendePhilip GiampietroNancy H. MillerCarol WiseRyan S. GrayLila Solnica-KrezelMitchell KnutsonMatthew B. DobbsChristina A. GurnettNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-7 (2018) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Gabe Haller Kevin McCall Supak Jenkitkasemwong Brooke Sadler Lilian Antunes Momchil Nikolov Julia Whittle Zachary Upshaw Jimann Shin Erin Baschal Carlos Cruchaga Matthew Harms Cathleen Raggio Jose A. Morcuende Philip Giampietro Nancy H. Miller Carol Wise Ryan S. Gray Lila Solnica-Krezel Mitchell Knutson Matthew B. Dobbs Christina A. Gurnett A missense variant in SLC39A8 is associated with severe idiopathic scoliosis |
| description |
The majority of scoliosis is considered idiopathic with onset in adolescence (AIS) and has a genetic contribution. Here, the authors perform an exome wide association study of data from 457 severe AIS cases and 987 controls, and find a missense variant in SLC39A8 is associated with AIS. |
| format |
article |
| author |
Gabe Haller Kevin McCall Supak Jenkitkasemwong Brooke Sadler Lilian Antunes Momchil Nikolov Julia Whittle Zachary Upshaw Jimann Shin Erin Baschal Carlos Cruchaga Matthew Harms Cathleen Raggio Jose A. Morcuende Philip Giampietro Nancy H. Miller Carol Wise Ryan S. Gray Lila Solnica-Krezel Mitchell Knutson Matthew B. Dobbs Christina A. Gurnett |
| author_facet |
Gabe Haller Kevin McCall Supak Jenkitkasemwong Brooke Sadler Lilian Antunes Momchil Nikolov Julia Whittle Zachary Upshaw Jimann Shin Erin Baschal Carlos Cruchaga Matthew Harms Cathleen Raggio Jose A. Morcuende Philip Giampietro Nancy H. Miller Carol Wise Ryan S. Gray Lila Solnica-Krezel Mitchell Knutson Matthew B. Dobbs Christina A. Gurnett |
| author_sort |
Gabe Haller |
| title |
A missense variant in SLC39A8 is associated with severe idiopathic scoliosis |
| title_short |
A missense variant in SLC39A8 is associated with severe idiopathic scoliosis |
| title_full |
A missense variant in SLC39A8 is associated with severe idiopathic scoliosis |
| title_fullStr |
A missense variant in SLC39A8 is associated with severe idiopathic scoliosis |
| title_full_unstemmed |
A missense variant in SLC39A8 is associated with severe idiopathic scoliosis |
| title_sort |
missense variant in slc39a8 is associated with severe idiopathic scoliosis |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/04b3d3a563384542b1a9a97bf011c0d4 |
| work_keys_str_mv |
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