Identification of anti-ErbB2 dual variable domain immunoglobulin (DVD-Ig™) proteins with unique activities.

Inhibiting ErbB2 signaling with monoclonal antibodies (mAbs) or small molecules is an established therapeutic strategy in oncology. We have developed anti-ErbB2 Dual Variable Domain Immunoglobulin (DVD-Ig) proteins that capture the function of a combination of two anti-ErbB2 antibodies. In addition,...

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Autores principales:	Jinming Gu, Jinsong Yang, Qing Chang, Xiaoqing Lu, Jieyi Wang, Mingjiu Chen, Tariq Ghayur, Jijie Gu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/04b66a2bcde548e28545c752fc2bb067
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id	oai:doaj.org-article:04b66a2bcde548e28545c752fc2bb067
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spelling	oai:doaj.org-article:04b66a2bcde548e28545c752fc2bb0672021-11-18T08:19:29ZIdentification of anti-ErbB2 dual variable domain immunoglobulin (DVD-Ig™) proteins with unique activities.1932-620310.1371/journal.pone.0097292https://doaj.org/article/04b66a2bcde548e28545c752fc2bb0672014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24824849/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Inhibiting ErbB2 signaling with monoclonal antibodies (mAbs) or small molecules is an established therapeutic strategy in oncology. We have developed anti-ErbB2 Dual Variable Domain Immunoglobulin (DVD-Ig) proteins that capture the function of a combination of two anti-ErbB2 antibodies. In addition, some of the anti-ErbB2 DVD-Ig proteins gain the new functions of enhancing ErbB2 signaling and cell proliferation in N87 cells. We further found that two DVD-Ig proteins, DVD687 and DVD688, have two distinct mechanisms of actions in Calu-3 and N87 cells. DVD687 enhances cell cycle progression while DVD688 induces apoptosis in N87 cells. Using a half DVD687, we found that avidity may play a key role in the agonist activity of DVD687 in N87 cells.Jinming GuJinsong YangQing ChangXiaoqing LuJieyi WangMingjiu ChenTariq GhayurJijie GuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e97292 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jinming Gu Jinsong Yang Qing Chang Xiaoqing Lu Jieyi Wang Mingjiu Chen Tariq Ghayur Jijie Gu Identification of anti-ErbB2 dual variable domain immunoglobulin (DVD-Ig™) proteins with unique activities.
description	Inhibiting ErbB2 signaling with monoclonal antibodies (mAbs) or small molecules is an established therapeutic strategy in oncology. We have developed anti-ErbB2 Dual Variable Domain Immunoglobulin (DVD-Ig) proteins that capture the function of a combination of two anti-ErbB2 antibodies. In addition, some of the anti-ErbB2 DVD-Ig proteins gain the new functions of enhancing ErbB2 signaling and cell proliferation in N87 cells. We further found that two DVD-Ig proteins, DVD687 and DVD688, have two distinct mechanisms of actions in Calu-3 and N87 cells. DVD687 enhances cell cycle progression while DVD688 induces apoptosis in N87 cells. Using a half DVD687, we found that avidity may play a key role in the agonist activity of DVD687 in N87 cells.
format	article
author	Jinming Gu Jinsong Yang Qing Chang Xiaoqing Lu Jieyi Wang Mingjiu Chen Tariq Ghayur Jijie Gu
author_facet	Jinming Gu Jinsong Yang Qing Chang Xiaoqing Lu Jieyi Wang Mingjiu Chen Tariq Ghayur Jijie Gu
author_sort	Jinming Gu
title	Identification of anti-ErbB2 dual variable domain immunoglobulin (DVD-Ig™) proteins with unique activities.
title_short	Identification of anti-ErbB2 dual variable domain immunoglobulin (DVD-Ig™) proteins with unique activities.
title_full	Identification of anti-ErbB2 dual variable domain immunoglobulin (DVD-Ig™) proteins with unique activities.
title_fullStr	Identification of anti-ErbB2 dual variable domain immunoglobulin (DVD-Ig™) proteins with unique activities.
title_full_unstemmed	Identification of anti-ErbB2 dual variable domain immunoglobulin (DVD-Ig™) proteins with unique activities.
title_sort	identification of anti-erbb2 dual variable domain immunoglobulin (dvd-ig™) proteins with unique activities.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/04b66a2bcde548e28545c752fc2bb067
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Identification of anti-ErbB2 dual variable domain immunoglobulin (DVD-Ig™) proteins with unique activities.

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