Depressive and Anxiety Symptoms Are Predictors of Seizure Recurrence in Adults With Newly Diagnosed Epilepsy

Objective: To investigate whether emerging depressive and anxiety symptoms are predictors of seizure recurrence in a cohort of patients with newly diagnosed epilepsy (PWNDE) who did not have a history of psychiatric diagnosis.Methods: A cohort of 283 PWNDE were psychiatrically assessed before antise...

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Autores principales:	Rui Zhong, Qingling Chen, Xinyue Zhang, Nan Li, Weihong Lin
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	depressive symptoms anxiety symptoms newly diagnosed epilepsy seizure recurrence predictor Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/04baaf24368b43908c58d48e10506d1c
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spelling	oai:doaj.org-article:04baaf24368b43908c58d48e10506d1c2021-11-30T19:52:14ZDepressive and Anxiety Symptoms Are Predictors of Seizure Recurrence in Adults With Newly Diagnosed Epilepsy1664-064010.3389/fpsyt.2021.784737https://doaj.org/article/04baaf24368b43908c58d48e10506d1c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.784737/fullhttps://doaj.org/toc/1664-0640Objective: To investigate whether emerging depressive and anxiety symptoms are predictors of seizure recurrence in a cohort of patients with newly diagnosed epilepsy (PWNDE) who did not have a history of psychiatric diagnosis.Methods: A cohort of 283 PWNDE were psychiatrically assessed before antiseizure medication (ASM) therapy and were followed for 12 months to assess seizure recurrence. The influence of depressive and anxiety symptoms score on seizure recurrence was assessed using univariate and multivariate binary logistic regression analysis. Receiver operating characteristic (ROC) curve analysis was utilized.Results: A total of 283 individuals were included in final analysis, and 115 patients (40.6%) experienced seizure recurrence during follow-up. In multivariate logistic regression analysis, NDDI-E and GAD-7 score were associated with an increased risk of seizure recurrence with an adjusted OR of 1.360 (CI: 1.176–1.572; P < 0.001) and 1.101 (CI: 1.004–1.209; P = 0.041), respectively. Additionally, the adjusted OR and 95% CI of seizure recurrence for the “high NDDI-E score and high GAD-7 score” vs. “not high NDDI-E score and not high GAD-7 score” was 7.059 (3.521–14.149) (P for trend < 0.001).Conclusion: We found that an emergence of new psychiatric symptoms including depressive and anxiety symptoms were predictors of seizure recurrence in adults with newly diagnosed epilepsy who did not have psychiatric history.Rui ZhongQingling ChenXinyue ZhangNan LiWeihong LinFrontiers Media S.A.articledepressive symptomsanxiety symptomsnewly diagnosed epilepsyseizure recurrencepredictorPsychiatryRC435-571ENFrontiers in Psychiatry, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	depressive symptoms anxiety symptoms newly diagnosed epilepsy seizure recurrence predictor Psychiatry RC435-571
spellingShingle	depressive symptoms anxiety symptoms newly diagnosed epilepsy seizure recurrence predictor Psychiatry RC435-571 Rui Zhong Qingling Chen Xinyue Zhang Nan Li Weihong Lin Depressive and Anxiety Symptoms Are Predictors of Seizure Recurrence in Adults With Newly Diagnosed Epilepsy
description	Objective: To investigate whether emerging depressive and anxiety symptoms are predictors of seizure recurrence in a cohort of patients with newly diagnosed epilepsy (PWNDE) who did not have a history of psychiatric diagnosis.Methods: A cohort of 283 PWNDE were psychiatrically assessed before antiseizure medication (ASM) therapy and were followed for 12 months to assess seizure recurrence. The influence of depressive and anxiety symptoms score on seizure recurrence was assessed using univariate and multivariate binary logistic regression analysis. Receiver operating characteristic (ROC) curve analysis was utilized.Results: A total of 283 individuals were included in final analysis, and 115 patients (40.6%) experienced seizure recurrence during follow-up. In multivariate logistic regression analysis, NDDI-E and GAD-7 score were associated with an increased risk of seizure recurrence with an adjusted OR of 1.360 (CI: 1.176–1.572; P < 0.001) and 1.101 (CI: 1.004–1.209; P = 0.041), respectively. Additionally, the adjusted OR and 95% CI of seizure recurrence for the “high NDDI-E score and high GAD-7 score” vs. “not high NDDI-E score and not high GAD-7 score” was 7.059 (3.521–14.149) (P for trend < 0.001).Conclusion: We found that an emergence of new psychiatric symptoms including depressive and anxiety symptoms were predictors of seizure recurrence in adults with newly diagnosed epilepsy who did not have psychiatric history.
format	article
author	Rui Zhong Qingling Chen Xinyue Zhang Nan Li Weihong Lin
author_facet	Rui Zhong Qingling Chen Xinyue Zhang Nan Li Weihong Lin
author_sort	Rui Zhong
title	Depressive and Anxiety Symptoms Are Predictors of Seizure Recurrence in Adults With Newly Diagnosed Epilepsy
title_short	Depressive and Anxiety Symptoms Are Predictors of Seizure Recurrence in Adults With Newly Diagnosed Epilepsy
title_full	Depressive and Anxiety Symptoms Are Predictors of Seizure Recurrence in Adults With Newly Diagnosed Epilepsy
title_fullStr	Depressive and Anxiety Symptoms Are Predictors of Seizure Recurrence in Adults With Newly Diagnosed Epilepsy
title_full_unstemmed	Depressive and Anxiety Symptoms Are Predictors of Seizure Recurrence in Adults With Newly Diagnosed Epilepsy
title_sort	depressive and anxiety symptoms are predictors of seizure recurrence in adults with newly diagnosed epilepsy
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/04baaf24368b43908c58d48e10506d1c
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Depressive and Anxiety Symptoms Are Predictors of Seizure Recurrence in Adults With Newly Diagnosed Epilepsy

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