Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model

Astrocyte activation may contribute to neurodegenerative disease. Here the authors show that the combined knockout of three factors known to promote astrogliosis, IL-1α, TNFα and C1qa, leads to improved survival in the SOD1 G93A mouse model of ALS.

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Autores principales:	Kevin A. Guttenplan, Maya K. Weigel, Drew I. Adler, Julien Couthouis, Shane A. Liddelow, Aaron D. Gitler, Ben A. Barres
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/04bb3c77114848c1a13fa651c535c520
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spelling	oai:doaj.org-article:04bb3c77114848c1a13fa651c535c5202021-12-02T16:23:44ZKnockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model10.1038/s41467-020-17514-92041-1723https://doaj.org/article/04bb3c77114848c1a13fa651c535c5202020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17514-9https://doaj.org/toc/2041-1723Astrocyte activation may contribute to neurodegenerative disease. Here the authors show that the combined knockout of three factors known to promote astrogliosis, IL-1α, TNFα and C1qa, leads to improved survival in the SOD1 G93A mouse model of ALS.Kevin A. GuttenplanMaya K. WeigelDrew I. AdlerJulien CouthouisShane A. LiddelowAaron D. GitlerBen A. BarresNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kevin A. Guttenplan Maya K. Weigel Drew I. Adler Julien Couthouis Shane A. Liddelow Aaron D. Gitler Ben A. Barres Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model
description	Astrocyte activation may contribute to neurodegenerative disease. Here the authors show that the combined knockout of three factors known to promote astrogliosis, IL-1α, TNFα and C1qa, leads to improved survival in the SOD1 G93A mouse model of ALS.
format	article
author	Kevin A. Guttenplan Maya K. Weigel Drew I. Adler Julien Couthouis Shane A. Liddelow Aaron D. Gitler Ben A. Barres
author_facet	Kevin A. Guttenplan Maya K. Weigel Drew I. Adler Julien Couthouis Shane A. Liddelow Aaron D. Gitler Ben A. Barres
author_sort	Kevin A. Guttenplan
title	Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model
title_short	Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model
title_full	Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model
title_fullStr	Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model
title_full_unstemmed	Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model
title_sort	knockout of reactive astrocyte activating factors slows disease progression in an als mouse model
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/04bb3c77114848c1a13fa651c535c520
work_keys_str_mv	AT kevinaguttenplan knockoutofreactiveastrocyteactivatingfactorsslowsdiseaseprogressioninanalsmousemodel AT mayakweigel knockoutofreactiveastrocyteactivatingfactorsslowsdiseaseprogressioninanalsmousemodel AT drewiadler knockoutofreactiveastrocyteactivatingfactorsslowsdiseaseprogressioninanalsmousemodel AT juliencouthouis knockoutofreactiveastrocyteactivatingfactorsslowsdiseaseprogressioninanalsmousemodel AT shanealiddelow knockoutofreactiveastrocyteactivatingfactorsslowsdiseaseprogressioninanalsmousemodel AT aarondgitler knockoutofreactiveastrocyteactivatingfactorsslowsdiseaseprogressioninanalsmousemodel AT benabarres knockoutofreactiveastrocyteactivatingfactorsslowsdiseaseprogressioninanalsmousemodel
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Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model

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