Characterization of Optimized TiO2 Nanotubes Morphology for Medical Implants: Biological Activity and Corrosion Resistance

Ricardo Pereira Nogueira,1,2 Jose Deuzimar Uchoa,3,4 Fanny Hilario,2 Gabriela de Fátima Santana-Melo,5 Luana Marotta Reis de Vasconcellos,5 Fernanda Roberta Marciano,6 Virginie Roche,2 Alberto Moreira Jorge Junior,2,7 Anderson Oliveira Lobo4 1Chemical Engineering Department, Khalifa Unive...

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Autores principales:	Nogueira RP, Deuzimar Uchoa J, Hilario F, Santana-Melo GDF, de Vasconcellos LMR, Marciano FR, Roche V, Moreira Jorge Junior A, Lobo AO
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	surface modification tio2 nanotubes commercially pure titanium bioactivity. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/04bc854eee984802ba2652bd06db27ae
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spelling	oai:doaj.org-article:04bc854eee984802ba2652bd06db27ae2021-12-02T15:59:50ZCharacterization of Optimized TiO2 Nanotubes Morphology for Medical Implants: Biological Activity and Corrosion Resistance1178-2013https://doaj.org/article/04bc854eee984802ba2652bd06db27ae2021-01-01T00:00:00Zhttps://www.dovepress.com/characterization-of-optimized-tio2-nanotubes-morphology-for-medical-im-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ricardo Pereira Nogueira,1,2 Jose Deuzimar Uchoa,3,4 Fanny Hilario,2 Gabriela de Fátima Santana-Melo,5 Luana Marotta Reis de Vasconcellos,5 Fernanda Roberta Marciano,6 Virginie Roche,2 Alberto Moreira Jorge Junior,2,7 Anderson Oliveira Lobo4 1Chemical Engineering Department, Khalifa University of Science and Technology, Abu Dhabi 127788, United Arab Emirates; 2Université Grenoble Alpes, Université Savoie Mont Blanc, CNRS, GrenobleINP*LEPMI, Grenoble 38000, France; 3Federal Institute of Education, Science and Technology of Piauí, Teresina 64053-390, Brazil; 4Interdisciplinary Laboratory for Advanced Materials, BioMatLab Group, Materials Science and Engineering Graduate Program, UFPI – Federal University of Piaui, Teresina 64049-550 Brazil; 5Department of Bioscience and Oral Diagnosis, Institute of Science and Technology, Sao Paulo State University, Sao José dos Campos 12245-000, Brazil; 6Department of Physics, Federal University of Piaui, Teresina PI 64049-550 Brazil; 7Department of Materials Engineering, Federal University of São Carlos, São Carlos 13565-905, BrazilCorrespondence: Anderson Oliveira LoboCampus Universitário Ministro Petrônio Portella, Av. Universitária, s/n, Centro de Tecnologia, Laboratório Interdisciplinar de Materiais Avançados, Ininga, Teresina, PI 64049-550, BrazilTel +55 86 32371057Email lobo@ufpi.edu.brBackground: Nanostructured surface modifications of Ti-based biomaterials are moving up from a highly-promising to a successfully-implemented approach to developing safe and reliable implants.Methods: The study’s main objective is to help consolidate the knowledge and identify the more suitable experimental strategies related to TiO2 nanotubes-modified surfaces. In this sense, it proposes the thorough investigation of two optimized nanotubes morphologies in terms of their biological activity (cell cytotoxicity, alkaline phosphatase activity, alizarin red mineralization test, and cellular adhesion) and their electrochemical behavior in simulated body fluid (SBF) electrolyte. Layers of small-short and large-long nanotubes were prepared and investigated in their amorphous and crystallized states and compared to non-anodized samples.Results: Results show that much more than the surface area development associated with the nanotubes’ growth; it is the heat treatment-induced change from amorphous to crystalline anatase-rutile structures that ensure enhanced biological activity coupled to high corrosion resistance.Conclusion: Compared to both non-anodized and amorphous nanotubes layers, the crystallized nano-structures’ outstanding bioactivity was related to the remarkable increase in their hydrophilic behavior, while the enhanced electrochemical stability was ascribed to the thickening of the dense rutile barrier layer at the Ti surface beneath the nanotubes.Keywords: surface modification, TiO2 nanotubes, commercially pure titanium, bioactivityNogueira RPDeuzimar Uchoa JHilario FSantana-Melo GDFde Vasconcellos LMRMarciano FRRoche VMoreira Jorge Junior ALobo AODove Medical Pressarticlesurface modificationtio2 nanotubescommercially pure titaniumbioactivity.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 667-682 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	surface modification tio2 nanotubes commercially pure titanium bioactivity. Medicine (General) R5-920
spellingShingle	surface modification tio2 nanotubes commercially pure titanium bioactivity. Medicine (General) R5-920 Nogueira RP Deuzimar Uchoa J Hilario F Santana-Melo GDF de Vasconcellos LMR Marciano FR Roche V Moreira Jorge Junior A Lobo AO Characterization of Optimized TiO2 Nanotubes Morphology for Medical Implants: Biological Activity and Corrosion Resistance
description	Ricardo Pereira Nogueira,1,2 Jose Deuzimar Uchoa,3,4 Fanny Hilario,2 Gabriela de Fátima Santana-Melo,5 Luana Marotta Reis de Vasconcellos,5 Fernanda Roberta Marciano,6 Virginie Roche,2 Alberto Moreira Jorge Junior,2,7 Anderson Oliveira Lobo4 1Chemical Engineering Department, Khalifa University of Science and Technology, Abu Dhabi 127788, United Arab Emirates; 2Université Grenoble Alpes, Université Savoie Mont Blanc, CNRS, GrenobleINP*LEPMI, Grenoble 38000, France; 3Federal Institute of Education, Science and Technology of Piauí, Teresina 64053-390, Brazil; 4Interdisciplinary Laboratory for Advanced Materials, BioMatLab Group, Materials Science and Engineering Graduate Program, UFPI – Federal University of Piaui, Teresina 64049-550 Brazil; 5Department of Bioscience and Oral Diagnosis, Institute of Science and Technology, Sao Paulo State University, Sao José dos Campos 12245-000, Brazil; 6Department of Physics, Federal University of Piaui, Teresina PI 64049-550 Brazil; 7Department of Materials Engineering, Federal University of São Carlos, São Carlos 13565-905, BrazilCorrespondence: Anderson Oliveira LoboCampus Universitário Ministro Petrônio Portella, Av. Universitária, s/n, Centro de Tecnologia, Laboratório Interdisciplinar de Materiais Avançados, Ininga, Teresina, PI 64049-550, BrazilTel +55 86 32371057Email lobo@ufpi.edu.brBackground: Nanostructured surface modifications of Ti-based biomaterials are moving up from a highly-promising to a successfully-implemented approach to developing safe and reliable implants.Methods: The study’s main objective is to help consolidate the knowledge and identify the more suitable experimental strategies related to TiO2 nanotubes-modified surfaces. In this sense, it proposes the thorough investigation of two optimized nanotubes morphologies in terms of their biological activity (cell cytotoxicity, alkaline phosphatase activity, alizarin red mineralization test, and cellular adhesion) and their electrochemical behavior in simulated body fluid (SBF) electrolyte. Layers of small-short and large-long nanotubes were prepared and investigated in their amorphous and crystallized states and compared to non-anodized samples.Results: Results show that much more than the surface area development associated with the nanotubes’ growth; it is the heat treatment-induced change from amorphous to crystalline anatase-rutile structures that ensure enhanced biological activity coupled to high corrosion resistance.Conclusion: Compared to both non-anodized and amorphous nanotubes layers, the crystallized nano-structures’ outstanding bioactivity was related to the remarkable increase in their hydrophilic behavior, while the enhanced electrochemical stability was ascribed to the thickening of the dense rutile barrier layer at the Ti surface beneath the nanotubes.Keywords: surface modification, TiO2 nanotubes, commercially pure titanium, bioactivity
format	article
author	Nogueira RP Deuzimar Uchoa J Hilario F Santana-Melo GDF de Vasconcellos LMR Marciano FR Roche V Moreira Jorge Junior A Lobo AO
author_facet	Nogueira RP Deuzimar Uchoa J Hilario F Santana-Melo GDF de Vasconcellos LMR Marciano FR Roche V Moreira Jorge Junior A Lobo AO
author_sort	Nogueira RP
title	Characterization of Optimized TiO2 Nanotubes Morphology for Medical Implants: Biological Activity and Corrosion Resistance
title_short	Characterization of Optimized TiO2 Nanotubes Morphology for Medical Implants: Biological Activity and Corrosion Resistance
title_full	Characterization of Optimized TiO2 Nanotubes Morphology for Medical Implants: Biological Activity and Corrosion Resistance
title_fullStr	Characterization of Optimized TiO2 Nanotubes Morphology for Medical Implants: Biological Activity and Corrosion Resistance
title_full_unstemmed	Characterization of Optimized TiO2 Nanotubes Morphology for Medical Implants: Biological Activity and Corrosion Resistance
title_sort	characterization of optimized tio2 nanotubes morphology for medical implants: biological activity and corrosion resistance
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/04bc854eee984802ba2652bd06db27ae
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Characterization of Optimized TiO2 Nanotubes Morphology for Medical Implants: Biological Activity and Corrosion Resistance

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