DOT1L safeguards cartilage homeostasis and protects against osteoarthritis

DOT1L is one of the few genes linked to osteoarthritis by human GWAS. Here the authors show that DOT1L-dependent histone methylation protects homeostasis of articular chondrocytes by SIRT1-dependent inhibition of canonical WNT signalling, and that inhibition of DOT1L can drive osteoarthritic disease...

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Autores principales:	Silvia Monteagudo, Frederique M. F. Cornelis, Carolina Aznar-Lopez, Ploi Yibmantasiri, Laura-An Guns, Peter Carmeliet, Frédéric Cailotto, Rik J. Lories
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/04bc89636776490eb64098d886437b56
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spelling	oai:doaj.org-article:04bc89636776490eb64098d886437b562021-12-02T14:40:32ZDOT1L safeguards cartilage homeostasis and protects against osteoarthritis10.1038/ncomms158892041-1723https://doaj.org/article/04bc89636776490eb64098d886437b562017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15889https://doaj.org/toc/2041-1723DOT1L is one of the few genes linked to osteoarthritis by human GWAS. Here the authors show that DOT1L-dependent histone methylation protects homeostasis of articular chondrocytes by SIRT1-dependent inhibition of canonical WNT signalling, and that inhibition of DOT1L can drive osteoarthritic disease in mice.Silvia MonteagudoFrederique M. F. CornelisCarolina Aznar-LopezPloi YibmantasiriLaura-An GunsPeter CarmelietFrédéric CailottoRik J. LoriesNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Silvia Monteagudo Frederique M. F. Cornelis Carolina Aznar-Lopez Ploi Yibmantasiri Laura-An Guns Peter Carmeliet Frédéric Cailotto Rik J. Lories DOT1L safeguards cartilage homeostasis and protects against osteoarthritis
description	DOT1L is one of the few genes linked to osteoarthritis by human GWAS. Here the authors show that DOT1L-dependent histone methylation protects homeostasis of articular chondrocytes by SIRT1-dependent inhibition of canonical WNT signalling, and that inhibition of DOT1L can drive osteoarthritic disease in mice.
format	article
author	Silvia Monteagudo Frederique M. F. Cornelis Carolina Aznar-Lopez Ploi Yibmantasiri Laura-An Guns Peter Carmeliet Frédéric Cailotto Rik J. Lories
author_facet	Silvia Monteagudo Frederique M. F. Cornelis Carolina Aznar-Lopez Ploi Yibmantasiri Laura-An Guns Peter Carmeliet Frédéric Cailotto Rik J. Lories
author_sort	Silvia Monteagudo
title	DOT1L safeguards cartilage homeostasis and protects against osteoarthritis
title_short	DOT1L safeguards cartilage homeostasis and protects against osteoarthritis
title_full	DOT1L safeguards cartilage homeostasis and protects against osteoarthritis
title_fullStr	DOT1L safeguards cartilage homeostasis and protects against osteoarthritis
title_full_unstemmed	DOT1L safeguards cartilage homeostasis and protects against osteoarthritis
title_sort	dot1l safeguards cartilage homeostasis and protects against osteoarthritis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/04bc89636776490eb64098d886437b56
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DOT1L safeguards cartilage homeostasis and protects against osteoarthritis

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