Comprehensive profiling of the ligand binding landscapes of duplexed aptamer families reveals widespread induced fit

Duplexed aptamers are a common biosensor format; however, how complementary strand sequence, length, and position modulate ligand binding is not well understood. Here, the authors introduce ACE-Scan to comprehensively map binding landscapes, uncovering hotspots of enhanced binding by induced fit.

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Detalles Bibliográficos
Autores principales:	Jeffrey D. Munzar, Andy Ng, David Juncker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/04bd5e350758419d83822381478fe464
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spelling	oai:doaj.org-article:04bd5e350758419d83822381478fe4642021-12-02T14:40:06ZComprehensive profiling of the ligand binding landscapes of duplexed aptamer families reveals widespread induced fit10.1038/s41467-017-02556-32041-1723https://doaj.org/article/04bd5e350758419d83822381478fe4642018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02556-3https://doaj.org/toc/2041-1723Duplexed aptamers are a common biosensor format; however, how complementary strand sequence, length, and position modulate ligand binding is not well understood. Here, the authors introduce ACE-Scan to comprehensively map binding landscapes, uncovering hotspots of enhanced binding by induced fit.Jeffrey D. MunzarAndy NgDavid JunckerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jeffrey D. Munzar Andy Ng David Juncker Comprehensive profiling of the ligand binding landscapes of duplexed aptamer families reveals widespread induced fit
description	Duplexed aptamers are a common biosensor format; however, how complementary strand sequence, length, and position modulate ligand binding is not well understood. Here, the authors introduce ACE-Scan to comprehensively map binding landscapes, uncovering hotspots of enhanced binding by induced fit.
format	article
author	Jeffrey D. Munzar Andy Ng David Juncker
author_facet	Jeffrey D. Munzar Andy Ng David Juncker
author_sort	Jeffrey D. Munzar
title	Comprehensive profiling of the ligand binding landscapes of duplexed aptamer families reveals widespread induced fit
title_short	Comprehensive profiling of the ligand binding landscapes of duplexed aptamer families reveals widespread induced fit
title_full	Comprehensive profiling of the ligand binding landscapes of duplexed aptamer families reveals widespread induced fit
title_fullStr	Comprehensive profiling of the ligand binding landscapes of duplexed aptamer families reveals widespread induced fit
title_full_unstemmed	Comprehensive profiling of the ligand binding landscapes of duplexed aptamer families reveals widespread induced fit
title_sort	comprehensive profiling of the ligand binding landscapes of duplexed aptamer families reveals widespread induced fit
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/04bd5e350758419d83822381478fe464
work_keys_str_mv	AT jeffreydmunzar comprehensiveprofilingoftheligandbindinglandscapesofduplexedaptamerfamiliesrevealswidespreadinducedfit AT andyng comprehensiveprofilingoftheligandbindinglandscapesofduplexedaptamerfamiliesrevealswidespreadinducedfit AT davidjuncker comprehensiveprofilingoftheligandbindinglandscapesofduplexedaptamerfamiliesrevealswidespreadinducedfit
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Comprehensive profiling of the ligand binding landscapes of duplexed aptamer families reveals widespread induced fit

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