Comprehensive profiling of the ligand binding landscapes of duplexed aptamer families reveals widespread induced fit

Duplexed aptamers are a common biosensor format; however, how complementary strand sequence, length, and position modulate ligand binding is not well understood. Here, the authors introduce ACE-Scan to comprehensively map binding landscapes, uncovering hotspots of enhanced binding by induced fit.

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Detalles Bibliográficos
Autores principales: Jeffrey D. Munzar, Andy Ng, David Juncker
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/04bd5e350758419d83822381478fe464
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